Results 211 to 220 of about 95,123 (282)

Targeting aerobic glycolysis combats tyrosine kinase inhibitor resistance of hepatocellular carcinoma

International Journal of Cancer, Volume 158, Issue 3, Page 475-487, 1 February 2026.
Abstract Hepatocellular carcinoma (HCC) represents the predominant form of primary liver cancer and is frequently identified at a late stage, necessitating systemic therapy. However, resistance to first‐line tyrosine kinase inhibitor therapies, such as sorafenib and lenvatinib, remains a significant clinical challenge.
Longtao Zhao, Junjie Cheng, Yiming Zheng, Jing Wu, Jia Fan, Haixiang Sun, Chao Gao   +6 more
wiley   +1 more source

Emergence of BRCA Reversion Mutations in Prostate Cancer Prior to PARP Inhibitor Exposure: Clinical and Therapeutic Implications. [PDF]

Cancer Med
Lin DI, Lawrence E, Danziger N, Ye H, Decker B, Gjoerup O, Graf RP, Ross JS, Huang RSP, Elvin JA, Mata DA, McKay RR.   +11 more
europepmc   +1 more source

Exploring the principles of logotherapy in genetic counseling: Enhancing decision‐making, adaptation, and justice

Journal of Genetic Counseling, Volume 35, Issue 1, February 2026.
Abstract Logotherapy is a psychological approach originated by Viktor Frankl, shaped by the thesis that meaning can be discovered even in the most tragic of human circumstances, and through a human's will‐to‐meaning, that individuals have both freedom and responsibility to discover meanings in the moment and ultimate meanings from their unique ...
Nour Chanouha, Anna Chassevent, Ellen F. Macnamara, Kendra Schaa, Renata Thoeny, Janeta Tansey   +5 more
wiley   +1 more source

Distinct mechanisms of recognition of phosphorylated RNAPII C-terminal domain by BRCT repeats of the BRCA1-BARD1 complex. [PDF]

J Biol Chem
Klapstova V, Sedova K, Houser J, Sebesta M.   +3 more
europepmc   +1 more source

Radiogenomics: Current Understandings and Future Perspectives

MedComm, Volume 7, Issue 2, February 2026.
Radiogenomics links imaging phenotypes with genetic variations, offering potential for comprehensive understanding, cost‐effective diagnosis, and prognosis prediction to advance personalized medicine. However, its clinical application remains limited by several challenges.
Xinyu Zhang, Qingpei Lai, Jin Cao, Jerry Chi Fung Ching, Xinzhi Teng, Jiang Zhang, Shara Wee Yee Lee, Ge Ren, Jing Cai   +8 more
wiley   +1 more source

Managing healthcare for female BRCA carriers in the population screening era: developing a harmonized national policy for surveillance and risk-reduction. [PDF]

Isr J Health Policy Res
Michaelson-Cohen R, Armon S, Srebnik N, Volkow EK, Mor P, Gekhtman D, Rosengarten O, Lotan AM, Goldvaser H, Miller Y, Feldman DM, Molho RB, Levy MS, Kedar I, Goldberg Y, Raz Y, Simchoni S, Hoffman A, Linial M, Carmon E, Gatot I, Braha M, Shtoyerman RC, Mordechai S, Half EE, Katz L, Levi Z, Morag SB, Allweis TM, Friedman E, Levy-Lahad E, Lieberman S.   +31 more
europepmc   +1 more source

Generation of functional noncanonical donor splice sites by +2T variants in breast cancer susceptibility genes: impact on clinical interpretation

The Journal of Pathology, Volume 268, Issue 2, Page 150-163, February 2026.
Abstract Splicing dysregulation is a relevant mechanism of pathogenicity for variants in disease susceptibility genes. Variants affecting the critical intronic +1 and +2 GT nucleotides of the 5’ splice sites (5'ss) are generally strong indicators of pathogenicity.
Inés Llinares‐Burguet, Lara Sanoguera‐Miralles, Elena Bueno‐Martínez, Alicia García‐Álvarez, Alberto Valenzuela‐Palomo, Pedro Pérez‐Segura, Miguel de la Hoya, Eladio A Velasco‐Sampedro   +7 more
wiley   +1 more source

Association Analysis of <i>BRCA1</i>, <i>PPAP2B</i>, and <i>KCNN3</i> Gene Polymorphisms With Litter Size in Sheep. [PDF]

Vet Med Int
He Y, Wang X, Liang C, Chu M.
europepmc   +1 more source