Results 221 to 230 of about 95,123 (282)

Genomics and Discrimination in New Zealand Health and Life Insurance

Journal of the Royal Society of New Zealand, Volume 56, Issue 1, February 2026.
The use of genomics offers substantial benefits to society by revolutionising approaches to healthcare and personalised medicine. It enables early detection of genetic predispositions to various diseases, allowing for proactive and tailored treatment plans, access to clinical trials, and improved health outcomes.
Andrew N. Shelling, Harry G. Fraser, Kimberley Gamet, Fay Sowerby   +3 more
wiley   +1 more source

Mutational Landscape Analysis of BRCA1/2 and Identification of Extracellular-Vesicle-Related Biomarkers in Triple-Negative Breast Cancer. [PDF]

Biomedicines
Hu Y, Wu J, Sun L, Xie Z, Li M, Yuan L, Huang R, Zhang W.   +7 more
europepmc   +1 more source

New partners for BRCA1 [PDF]

Nature Structural & Molecular Biology, 2007
openaire   +2 more sources

A Novel Human Cellular System for Studying Normal Aging and for Anti‐Aging Discovery

Aging Cell, Volume 25, Issue 2, February 2026.
This study introduces a human cellular aging model using placental trophoblasts (hTSC‐STBs) that mimics key aging features like senescence and genomic instability. It aligns with human tissue aging and responds to anti‐aging treatments, offering a scalable platform to screen potential therapies and bridge lab findings to clinical applications ...
Zhen Feng, Cheuk Shuen Li, Haifeng Fu, Wenxin Jiang, Weiyu Zhang, Yingzhang Huang, Yunying Huang, Timothy Theodore Ka Ki Tam, Yang Li, Fang Liu, Liming Lu, Yin Lau Lee, William Shu Biu Yeung, Gordon Dougan, Pentao Liu   +14 more
wiley   +1 more source

Germline Variants in the Immune Response-Related Genes: Possible Modifying Effect on Age-Dependent <i>BRCA1</i> Penetrance in Breast Cancer Patient. [PDF]

Cancers (Basel)
Kuligina ES, Martianov AS, Yanus GA, Gorgul YA, Suspitsin EN, Romanko AA, Tumakova AV, Togo AV, Kashyap A, Cybulski C, Lubiński J, Imyanitov EN.   +11 more
europepmc   +1 more source

Deciphering the Transcriptomic Signatures of Aging Across Organs in Mice

Aging Cell, Volume 25, Issue 2, February 2026.
Comprehensive transcriptomic profiling of eight mouse organs across six ages reveals how aging reshapes biological processes. Trajectory and network analyses distinguish shared and organ‐specific signatures, charting the molecular landscape of systemic aging.
Sarah Morsy, Enzo Scifo, Kan Xie, Kristina Schaaf, Jenny Russ, Stefan Paulusch, Elena De Domenico, Paolo Salomoni, Daniele Bano, Dan Ehninger   +9 more
wiley   +1 more source

Different association of gBRCA1 and gBRCA2 variants with HER2-low status in invasive breast cancer: findings from a Ukrainian study. [PDF]

Sci Rep
Livshun S, Kozakov D, Kruhlykovа A, Koshyk O, Kobyliak N, Seleznov O, Matvieieva A, Shparyk Y, Volodko N, Zavizion V, Khmel A, Kharchenko K, Otchenash N, Andriiv A, Sulaieva O.   +14 more
europepmc   +1 more source

Regulation of R‐Loop Dynamics by Proteins and Long Noncoding RNAs: An Emerging Paradigm for Cancer Treatment

Cancer Science, Volume 117, Issue 2, Page 297-307, February 2026.
R‐loops are three‐stranded nucleic acid structures whose dysregulation leads to genomic instability and cancer progression. This review summarizes the protein and lncRNA machineries that regulate R‐loop dynamics and discusses the therapeutic potential of targeting these pathways in cancer.
Miho M. Suzuki, Keiko Shinjo, Tatsunori Nishimura, Yutaka Kondo   +3 more
wiley   +1 more source

The Risk of Breast Cancer According to Mutation Type and Position in Carriers of a Pathogenic Variant in <i>BRCA1</i>. [PDF]

Curr Oncol
Kotsopoulos J, Apostol AI, Metcalfe K, Jorgji D, Cybulski C, Gronwald J, Lubinski J, Moller P, Kim RH, Aeilts A, Ramón Y Cajal T, Pal T, Bordeleau L, Karlan BY, Singer CF, Foulkes WD, Couch FJ, Zakalik D, Fruscio R, Tung N, Sun P, Monteiro AN, Narod SA, Akbari MR, Hereditary Breast Cancer Clinical Study Group.   +24 more
europepmc   +1 more source

TGM2 Regulates Radiosensitivity via POGZ‐Mediated Repair of DNA Double‐Strand Breaks in Cervical Cancer

Cancer Science, Volume 117, Issue 2, Page 429-444, February 2026.
The present study revealed for the first time that TGM2 could regulate the radiosensitivity of cervical cancer via POGZ‐mediated DNA DSB repair. Our findings revealed that TGM2 regulates the radiosensitivity of cervical cancer and demonstrated that POGZ serves as a bridge linking TGM2 to the DNA damage repair process, and suggested a novel mechanistic ...
Yunbo Chi, Peng Dong, Ning Zhang, Baocai Liu, Qian Wang, Guanghui Cheng   +5 more
wiley   +1 more source