Results 261 to 270 of about 95,123 (282)
Some of the next articles are maybe not open access.
2018
?????????????? ?????????????????? ???????????????? ?? ?????????????????? ?? ???????????????? ???????????????? ?????????? BRCA1. BRCA1 ???????????? ???????????? ???????? ?? ?????????????????????????????? ?????????????????? ?????????????????????????????????? ???????????? (???????????????? ???????????????????? ??????????, ????????????????????????, ????????
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?????????????? ?????????????????? ???????????????? ?? ?????????????????? ?? ???????????????? ???????????????? ?????????? BRCA1. BRCA1 ???????????? ???????????? ???????? ?? ?????????????????????????????? ?????????????????? ?????????????????????????????????? ???????????? (???????????????? ???????????????????? ??????????, ????????????????????????, ????????
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Current Problems in Cancer, 2014
A hereditary breast cancer syndrome can present in a variety of ways ranging from an index case of early-onset breast cancer to an incidental finding during an endoscopy or a dermatological examination. A comprehensive review of the patient’s personal and family history is essential to accurately assess the risk for a hereditary cancer syndrome ...
Kimberly, King-Spohn, Robert, Pilarski
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A hereditary breast cancer syndrome can present in a variety of ways ranging from an index case of early-onset breast cancer to an incidental finding during an endoscopy or a dermatological examination. A comprehensive review of the patient’s personal and family history is essential to accurately assess the risk for a hereditary cancer syndrome ...
Kimberly, King-Spohn, Robert, Pilarski
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Cancer Investigation, 2001
The breast cancer susceptibility gene BRCA1 on chromosome 17q21 encodes an 1863 amino acid protein that is important for normal embryonic development. Germline mutations of this gene are linked to a significantly increased lifetime risk for breast and/or ovarian cancer, and recent studies suggest that the same may be true for prostate cancer.
E M, Rosen, S, Fan, I D, Goldberg
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The breast cancer susceptibility gene BRCA1 on chromosome 17q21 encodes an 1863 amino acid protein that is important for normal embryonic development. Germline mutations of this gene are linked to a significantly increased lifetime risk for breast and/or ovarian cancer, and recent studies suggest that the same may be true for prostate cancer.
E M, Rosen, S, Fan, I D, Goldberg
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Transcriptional regulation of BRCA1
1999Abstract : Germline mutations in BRCAl lead to an increased risk of breast and ovarian cancer, with loss of the second, normal allele critical to tumorigenesis. It was widely presumed that the cloning and characterization of genes involved in hereditary breast cancer would lead to a better understanding of the genesis of the more common non-inherited ...
Mary C. King, Shannon R. Payne
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BRCA1 regulation of transcription
Cancer Letters, 2006BRCA1, a tumor suppressor gene on chromosome 17q21, was identified in 1994 based on its linkage to hereditary breast and ovarian cancer syndromes. The BRCA1 gene encodes a 220 kDa nuclear phosphoprotein. Studies aimed at elucidating the mechanisms of its tumor suppressor activity have revealed, in part, that BRCA1 participates in the DNA damage ...
Eliot M, Rosen +2 more
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Journal of Cancer Research and Clinical Oncology, 1997
More than 100 mutations have been described for the breast-cancer-susceptibility gene BRCA1. The paper describes phenotypical aspects of three selected mutations located at the beginning, in the middle, and at the end of the gene. A remarkable decrease of the age of diagnosis of the mammary carcinoma is observed with increasing length of the putative ...
K, Grade +5 more
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More than 100 mutations have been described for the breast-cancer-susceptibility gene BRCA1. The paper describes phenotypical aspects of three selected mutations located at the beginning, in the middle, and at the end of the gene. A remarkable decrease of the age of diagnosis of the mammary carcinoma is observed with increasing length of the putative ...
K, Grade +5 more
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New England Journal of Medicine, 2010
The cellular machinery that transports BRCA1 protein to sites of DNA repair is critical to DNA integrity. Two recent studies have identified key components of this machinery.
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The cellular machinery that transports BRCA1 protein to sites of DNA repair is critical to DNA integrity. Two recent studies have identified key components of this machinery.
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2021
Aims. Breast cancer ranks first among cancers of the female population in Ukraine and in most countries abroad. However, data on the mutations frequencies in Ukraine for BRCA1 gene is limited. We investigated the variation and frequency of mutations in gene BRCA1 among patients with breast cancer in three regions of Ukraine. Methods.
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Aims. Breast cancer ranks first among cancers of the female population in Ukraine and in most countries abroad. However, data on the mutations frequencies in Ukraine for BRCA1 gene is limited. We investigated the variation and frequency of mutations in gene BRCA1 among patients with breast cancer in three regions of Ukraine. Methods.
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