Results 21 to 30 of about 95,123 (282)
TP53 loss initiates chromosomal instability in fallopian tube epithelial cells
Disease Models & Mechanisms, 2021 High-grade serous ovarian cancer (HGSOC) originates in the fallopian tube epithelium and is characterized by ubiquitous TP53 mutation and extensive chromosomal instability (CIN).
Daniel Bronder +16 more
doaj +1 more source
CLINICAL AND MORPHOLOGICAL FEATURES OF HEREDITARY OVARIAN CANCER
Сибирский онкологический журнал, 2017 Germ-line mutations in BRCA1 and BRCA2 genes are the most established risk factors for hereditary breast and ovarian cancers. The purpose of the study was to analyze BRCA1/2 testing in ovarian cancer patients. Materials and methods.
K. B. Kotiv +16 more
doaj +1 more source
Male Breast Carcinoma after Irradiation and Long-Term Phenothiazine Exposure: A Case Report
Case Reports in Oncology, 2020 We present a young male patient with breast cancer having several risk factors likely acting in consort: irradiation of the breast for gynecomastia in adolescence and a life-long administration of phenothiazine for schizophrenia from the age of 16 years,
Ragnar Hultborn +5 more
doaj +1 more source
A Case of Triple-Negative Breast Cancer with Germline Pathogenic Variants in Both BRCA1 and BRCA2
Case Reports in Oncology, 2021 We report a rare case of hereditary breast and ovarian cancer syndrome (HBOC) with pathogenic variants in both BRCA1 and BRCA2. The patient was a 78-year-old woman who visited the hospital after noticing a lump in her left breast 6 months before, which ...
Miyuki Kitahara +3 more
doaj +1 more source
BRCA1-Mediated Ubiquitylation [PDF]
Cell Cycle, 2006 The BRCA1 tumour suppressor and its heterodimeric partner BARD1 play crucial roles in coordinating cellular responses to DNA damage. Evidence also implicates these proteins in transcriptional regulation, cell cycle progression and meiotic sex chromosome inactivation, but their mode of action remains elusive.
openaire +2 more sources
Cancer Biology & Therapy, 2004 The BRCA1 tumor suppressor gene is expressed in all mammalian cells. Within these cells, the BRCA1 protein product interacts with several seemingly distinct nuclear complexes. Proteins within these complexes are potential targets for the E3-ubiquitin ligase activity associated with BRCA1:BARD1 complexes.
openaire +2 more sources
BJS (British Journal of Surgery), EarlyView., 2020 Recommendations for clinical and molecular identification of LS, surgical and endoscopic management of LS‐associated colorectal cancer and preventive measures for cancer were produced. The emphasis was on surgical and gastroenterological aspects of the cancer spectrum.
T. T. Seppälä +18 more
wiley +1 more source
Role of Single Nucleotide Polymorphisms in BRCA1 and BRCA2 Genes Relative to Previous Studies in Pakistan in the Prognosis of Breast Cancer [PDF]
Journal of Liaquat National HospitalBreast cancer is a complex disease characterized by a myriad of genetic alterations. Single nucleotide polymorphisms are particularly relevant due to small allelic variations.
Saba Munir +6 more
doaj +1 more source
Сибирский онкологический журнал, 2019 Currently, the presence of the germinal mutation BRCA1 5382insC in breast cancer patients is one of the determining factors for prescribing platinum-based drugs.
M. M. Tsyganov +7 more
doaj +1 more source
Cells, 2020 Research on repurposing the old alcohol-aversion drug disulfiram (DSF) for cancer treatment has identified inhibition of NPL4, an adaptor of the p97/VCP segregase essential for turnover of proteins involved in multiple pathways, as an unsuspected cancer ...
Dusana Majera +5 more
doaj +1 more source