Results 1 to 10 of about 68,702 (192)
The deubiquitinating enzyme Cezanne stabilizes BRCA1 by counteracting APC/C and Ube2S-dependent Lys11-linked ubiquitination. [PDF]
PLoS BiologyThe breast and ovarian tumor suppressor BRCA1 is a cell cycle-regulated protein and tumors with reduced BRCA1 protein level may share molecular features of BRCA1-mutant tumor and respond to PARPi therapy. Here, we identify that BRCA1 protein stability is
Longqiang Wang +4 more
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BRCA1 protein dose-dependent risk for embryonic oxidative DNA damage, embryopathies and neurodevelopmental disorders with and without ethanol exposure [PDF]
Redox BiologyAlthough widely known as a tumor suppressor, the breast cancer 1 susceptibility protein (BRCA1) is also important in development, where it regulates fetal DNA repair pathways that protect against DNA damage caused by physiological and drug-enhanced ...
Danielle M. Drake +6 more
doaj +2 more sources
BRCA1 mediates protein homeostasis through the ubiquitination of PERK and IRE1
iScience, 2022 Summary: Tumors with BRCA1 mutations have poor prognoses due to genomic instability. Yet this genomic instability has risks and BRCA1-deficient (def) cancer cells must develop pathways to mitigate these risks.
Robert Hromas +10 more
doaj +1 more source
Methylation of the tumor suppressor protein, BRCA1, influences its transcriptional cofactor function. [PDF]
PLoS ONE, 2010 Approximately half of hereditary breast cancers have mutations in either BRCA1 or BRCA2. BRCA1 is a multifaceted tumor suppressor protein that has implications in processes such as cell cycle, transcription, DNA damage response and chromatin remodeling ...
Irene Guendel +6 more
doaj +1 more source
BRCA1-Dependent Translational Regulation in Breast Cancer Cells. [PDF]
PLoS ONE, 2013 BRCA1 (Breast Cancer 1) has been implicated in a number of cellular processes, including transcription regulation, DNA damage repair and protein ubiquitination.
Estelle Dacheux +8 more
doaj +1 more source
BRCA1-Associated Protein 1 Interferes with BRCA1/BARD1 RING Heterodimer Activity [PDF]
Cancer Research, 2008 Abstract The breast and ovarian tumor suppressor BRCA1 constitutes a RING heterodimer E3 ligase with BARD1. BRCA1-associated protein 1 (BAP1) is a ubiquitin COOH-terminal hydrolase that was initially identified as a protein that bound to the RING finger domain of BRCA1.
Hiroyuki, Nishikawa +6 more
openaire +2 more sources
Redox Biology, 2021 The breast cancer 1 protein (BRCA1) facilitates DNA repair, preventing embryolethality and protecting the fetus from reactive oxygen species (ROS)-induced developmental disorders mediated by oxidatively damaged DNA.
Danielle M. Drake, Peter G. Wells
doaj +1 more source
Regulation of BRCA1 by protein degradation [PDF]
Oncogene, 1999 BRCA1, a tumor suppressor protein implicated in hereditary forms of breast and ovarian cancer, is transcriptionally regulated in a proliferation-dependent manner. In this study, we demonstrate a substantial role for proteolysis in regulating the BRCA1 steady-state protein level in several cell lines. N-acetyl-leu-leu-norleucinal (ALLN), an inhibitor of
M V, Blagosklonny +5 more
openaire +2 more sources
BAP1: Not just a BRCA1-associated protein [PDF]
Cancer Treatment Reviews, 2020 BRCA1-Associated Protein 1 (BAP1) is a ubiquitin carboxy-terminal hydrolase that has been established as a tumor suppressor, utilizing its deubiquitinating activity to regulate a number of processes including DNA damage repair, cell cycle control, chromatin modification, programmed cell death, and the immune response.
Louie, Bryan H, Kurzrock, Razelle
openaire +3 more sources
SIRT2 promotes BRCA1-BARD1 heterodimerization through deacetylation
Cell Reports, 2021 Summary: The breast cancer type I susceptibility protein (BRCA1) and BRCA1-associated RING domain protein I (BARD1) heterodimer promote genome integrity through pleiotropic functions, including DNA double-strand break (DSB) repair by homologous ...
Elizabeth V. Minten +5 more
doaj +1 more source