Results 91 to 100 of about 68,702 (192)

Mutations in BRCA2 and taxane resistance in prostate cancer

Scientific Reports, 2017
Mutations in BRCA1 or BRCA2 define a subset of prostate cancer patients. Herein, we address the question whether BRCA1/2 mutations have a predictive impact on chemotherapy with docetaxel, a widely used drug in patients with metastatic castration ...
Cathleen Nientiedt, Martina Heller, Volker Endris, Anna-Lena Volckmar, Stefanie Zschäbitz, María A. Tapia-Laliena, Anette Duensing, Dirk Jäger, Peter Schirmacher, Holger Sültmann, Albrecht Stenzinger, Markus Hohenfellner, Carsten Grüllich, Stefan Duensing   +13 more
doaj   +1 more source

The PER2:BRCA1:POU2F1(OCT-1) ternary complex represents a multi-component scaffold model for circadian gene regulation

Neurobiology of Sleep and Circadian Rhythms
The circadian clock component PER2 coordinates daily oscillations in gene expression across multiple tissues, yet its role in assembling multi-protein regulatory complexes remains incompletely understood.
Elizaveta Kadukhina, Siqi Jia, Linda M. Villa, Xiao Yi, Daniel G.S. Capelluto, Jonathan S. Briganti, Anne M. Brown, Carla V. Finkielstein   +7 more
doaj   +1 more source

Molecular docking analysis of the BRCA1 protein with compounds from Justica adhatoda L. [PDF]

Bioinformation, 2020
Jayaraman S, Veeraraghavan V, Sreekandan RN, Mohan SK, Suga SSD, Kamaraj D, Mohandoss S, Koora S.   +7 more
europepmc   +1 more source

Immunohistochemical Expression of BRCA1 Protein, ER, PR and Her2/neu in Breast Cancer: A Clinicopathological Study. [PDF]

Asian Pac J Cancer Prev, 2020
Hussein IA, Ahmed ST, Hameedi AD, Naji RZ, Alharbawi L, Alkhaytt M, Pity IS.   +6 more
europepmc   +1 more source

BRCA1 Protein Expression Predicts Survival in Glioblastoma Patients from an NRG Oncology RTOG Cohort.

Oncology, 2021
Vassilakopoulou M, Won M, Curran WJ, Souhami L, Prados MD, Langer CJ, Rimm DL, Hanna JA, Neumeister VM, Melian E, Diaz AZ, Atkins JN, Komarnicky LT, Schultz CJ, Howard SP, Zhang P, Dicker AP, Knisely JPS.   +17 more
europepmc   +1 more source

BRCA1 Protein Variant [PDF]

, 2020
openaire   +1 more source

Prevalence of BRCA1 gene mutations in female breast cancer patients in Mazandaran Province, Northern Iran

Egyptian Journal of Medical Human Genetics
Background Breast cancer is one of the major global health concerns, and the investigation of mutations in the BRCA1 gene is essential for prevention and treatment. Carriers of pathogenic BRCA1 gene variants face an increased risk of breast cancer during
Masoumeh Jangjou, Majid Alipour, Ramin Mofarrah, Soroush Alipour   +3 more
doaj   +1 more source

Regulating BRCA1 protein stability by cathepsin S-mediated ubiquitin degradation. [PDF]

Cell Death Differ, 2019
Kim S, Jin H, Seo HR, Lee HJ, Lee YS.
europepmc   +1 more source

BRCA1-Associated Protein 1 Testing in Cancer [PDF]

Journal of Thoracic Oncology, 2016
openaire   +2 more sources

Non canonical BRCA1 promotes cell survival via modulating PARP13-mediated SEC61G mRNA decay

Oncogenesis
BRCA1, a well-known tumor suppressor, maintains genomic integrity by facilitating homologous recombination (HR) repair and protecting DNA replication forks. However, its roles beyond DNA repair and replication remain largely unexplored.
Binghe Sun, Yuting Li, Yue Wu, Cong Wang, Jiawei Zhu, Wanying Zhang, Dake Li, Wancai Que, Guo Chen   +8 more
doaj   +1 more source