Results 141 to 150 of about 68,702 (192)

BRCA1/2, PALB2 mutations and first-line CDK4/6 inhibitor efficacy in HR+ metastatic breast cancer. [PDF]

Breast
Guinel T, Lusque A, Mailliez A, Massard V, Jacot W, Guiu S, de la Motte Rouge T, Brain E, Desmoulins I, Arnedos M, Bailleux C, Goncalves A, Levy C, Bachelot T, Bosquet L, Delaloge S, Frénel JS.   +16 more
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Integrating breast tumour homologous recombination deficiency status to aid germline BRCA1 and BRCA2 variant classification. [PDF]

EBioMedicine
Fortuno C, Zhang J, Koufariotis LT, Hollway G, Wood S, Pearson JV, Simpson PT, Lakhani SR, McCart Reed AE, Thorne H, Mann GB, Skandarajah AR, Devereux L, Zhao Q, De Silva DL, Lindeman GJ, Waring P, James PA, Campbell I, Spurdle AB, Waddell N.   +20 more
europepmc   +1 more source

Revisiting the impact of BRCA1 pathogenic variants on the aggressiveness of prostate cancer. [PDF]

JNCI Cancer Spectr
Sasagawa H, Narita S, Matsuda K, Kosaka T, Momozawa Y.   +4 more
europepmc   +1 more source

HSP90 buffers deleterious genetic variations in BRCA1. [PDF]

Mol Cell
Gracia B, Zhang XH, Montes P, Pham TC, Huang M, Chen J, Karras GI.   +6 more
europepmc   +1 more source

Meeting abstracts from the Annual Conference "Clinical Genetics of Cancer 2024". [PDF]

Hered Cancer Clin Pract
europepmc   +1 more source

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Roles of BRCA1 and its interacting proteins

BioEssays, 2000
Germline mutations of BRCA1 predispose women to breast and ovarian cancers. BRCA1 contains several functional domains that interact directly or indirectly with a variety of molecules, including tumor suppressors (p53, RB, BRCA2 and ATM), oncogenes (c-Myc, casein kinase II and E2F), DNA damage repair proteins (RAD50 and RAD51), cell-cycle regulators ...
C X, Deng, S G, Brodie
openaire   +2 more sources

Characterization of BRCA1 Protein Product

2000
Abstract : Germline mutations in the BRCA1 tumor suppressor gene have been implicated in hereditary breast and ovarian cancers. As part of our ultimate goal to characterize novel interactions between BRCA1 and other proteins involved in well-defined pathways, we have pursued an area of research that is just beginning to receive a great deal of ...
Michael Press, John J. Park
openaire   +1 more source

Functional Domains of the BRCA1 and BRCA2 Proteins

Journal of Mammary Gland Biology and Neoplasia, 1998
The BRCA1 and BRCA2 genes encode large unrelated proteins that presumably function as tumor suppressors in normal epithelial cells of the breast. However, the primary amino acid sequences of these proteins provide few insights into the mechanisms by which BRCA1 and BRCA2 inhibit tumor development.
R, Baer, W H, Lee
openaire   +2 more sources