Results 151 to 160 of about 68,702 (192)

Localization of BRCA1 Protein at the Cellular Level

Journal of Mammary Gland Biology and Neoplasia, 1998
Based on its amino acid sequence and the existence of three nuclear localization signal (NLS)3 regions, BRCA1 is likely to be a cell cycle-dependent nuclear protein, regulated by cyclin-dependent kinases (cdk) and associated with nuclear proteins such as Rad51 and BARD1, involved in transcription regulation and participating in DNA replication ...
C R, De Potter, E D, Coene, V R, Schelfhout   +2 more
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Protein Partners of the BRCA1 Tumor Suppressor

Breast Disease, 1998
The primary amino acid sequence of BRCA1 offers few clues about the mechanism by which it suppresses tumor formation in normal breast and ovarian tissues. In an effort to unravel its biological functions, investigators have sought to identify the proteins that interact with BRCA1 in vivo.
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Western Analysis of Breast Cancer 1 Protein (BRCA1)

2019
Known for its tumor suppressor activity in breast and ovarian cancers, the breast cancer 1 susceptibility gene (Brca1) is involved in a variety of cellular pathways including DNA repair, antioxidant signaling, apoptosis, and cell cycle regulation. BRCA1 can translocate between the cytoplasm and nucleus to perform its various roles.
Danielle M, Drake, Peter G, Wells
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Localization of BRCA1 Protein in Human Breast Cancer Cells

Breast Cancer Research and Treatment, 2003
There is still an ongoing debate concerning the cellular localization of BRCA1 protein in breast cancer. To address this question, we compared the localization of BRCA1 protein using several monoclonal (Ab-1) or polyclonal (C20, D20, I20) antibodies under different technical conditions on human breast cancer cell lines.
Monique, Chambon, Philippe, Nirdé, Michel, Gleizes, Pascal, Roger, Françoise, Vignon   +4 more
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Breast cancer risk and the BRCA1 interacting protein CTIP

Breast Cancer Research and Treatment, 2007
Mutations in BRCA1 predispose to breast cancer. CTIP interacts with BRCA1 and so could also be associated with increased risk. We screened CTIP for germline mutations in 210 probands of breast cancer families including 129 families with no mutations in BRCA1 or BRCA2. No coding variants were detected in CTIP, therefore, it is unlikely to be involved in
Kylie L, Gorringe, David Y H, Choong, Geoffrey J, Lindeman, Jane E, Visvader, Ian G, Campbell   +4 more
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Highlight: BRCA1 and BRCA2 proteins in breast cancer

Microscopy Research and Technique, 2002
AbstractHeterozygous carriers of loss‐of‐function germline mutations in the BRCA1 or BRCA2 breast cancer susceptibility genes have a predisposition to breast and ovarian cancer. Multiple functions have been ascribed to the products of these genes, linking them to pathways that inhibit progression to neoplasia.
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Immunohistochemical Loss of BRCA1 Protein in Uterine Serous Carcinoma

International Journal of Gynecological Pathology, 2014
Uterine serous carcinoma is a uncommon aggressive variant of endometrial cancer whose biologic origin is unclear. Mutations in p53 and BRCA1 genes play a key role in ovarian serous carcinogenesis. We investigated whether the loss of BRCA1 expression plays a similar role in uterine serous carcinoma.
Jonathan L, Hecht, Panagiotis A, Konstantinopoulos, Christopher S, Awtrey, Robert A, Soslow   +3 more
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Loss of nuclear BRCA1 protein staining in normal tissue cells derived from BRCA1 and BRCA2 mutation carriers

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2007
Enhanced genomic instability has been recently reported in normal cells derived from BRCA1/2 mutation carriers when placed in vitro in non-physiological stress conditions. We present here original data which help to explain the observed genomic instability.
De Brakeleer, Sylvia, Bogdani, M, De Grève, Jacques, Decock, J., Sermijn, Erika, Bonduelle, Mary-Louise, Goelen, Guido, Teugels, Erik   +7 more
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Protein–Protein Interaction Inhibitors of BRCA1 Discovered Using Small Molecule Microarrays

2016
Microarray screening technology has transformed the life sciences arena over the last decade. The platform is widely used in the area of mapping interaction networks, to molecular fingerprinting and small molecular inhibitor discovery. The technique has significantly impacted both basic and applied research.
Zhenkun, Na, Sijun, Pan, Mahesh, Uttamchandani, Shao Q, Yao   +3 more
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BRCA1 protein products: Antibody specificity…

Nature Genetics, 1996
C A, Wilson, M N, Payton, S K, Pekar, K, Zhang, R E, Pacifici, J L, Gudas, S, Thukral, F J, Calzone, D M, Reese, D I, Slamon   +9 more
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