Results 11 to 20 of about 68,702 (192)

Abnormal expression of BRCA1 and BRCA1‐interactive DNA‐repair proteins in breast carcinomas [PDF]

International Journal of Cancer, 2000
Breast cancer is one of the most common malignancies among women. The molecular mechanisms involved in breast carcinogenesis, however, remain to be elucidated. Although somatic mutation of BRCA1 is rare, BRCA1 protein expression is reduced in about 30% of sporadic breast carcinomas (Yoshikawa et al., Clin.
K, Yoshikawa, T, Ogawa, R, Baer, H, Hemmi, K, Honda, A, Yamauchi, T, Inamoto, K, Ko, S, Yazumi, H, Motoda, H, Kodama, S, Noguchi, A F, Gazdar, Y, Yamaoka, R, Takahashi   +14 more
openaire   +2 more sources

CRL4-DCAF8L1 Regulates BRCA1 and BARD1 Protein Stability [PDF]

International Journal of Biological Sciences, 2022
BRCA1 is frequently down-regulated in breast cancer, the underlying mechanism is unclear. Here we identified DCAF8L1, an X-linked gene product, as a DDB1-Cullin associated Factor (DCAF) for CUL4 E3 ligases to target BRCA1 and BARD1 for proteasomal degradation.
Liu, Fei, Han, Qianying, Zhang, Ting, Chang, Fen, Deng, Jingcheng, Huang, Xiaotian, Wang, Weiping, Xu, Yongjie, Li, Qin, Xu, Luzheng, Zhang, Bo, Li, Wentong, Li, Li, Su, Yanrong, Li, Yang, Shao, Genze   +15 more
openaire   +2 more sources

BRCA1‐associated protein (BAP1)‐inactivated melanocytic tumors [PDF]

Journal of Cutaneous Pathology, 2019
AbstractAlthough discussed using variable terminology, cutaneous BRCA1‐associated protein (BAP1)‐inactivated melanocytic tumor (BIMT) has been considered a discrete diagnostic entity since 2011. Here, we review the initial genomic studies that identified these distinct melanocytic tumors and the clinical and histopathological features that define these
Arianna J. Zhang, Patrick S. Rush, Hensin Tsao, Lyn M. Duncan   +3 more
openaire   +2 more sources

BRCA1 interacts with Smad3 and regulates Smad3-mediated TGF-beta signaling during oxidative stress responses. [PDF]

PLoS ONE, 2009
BRCA1 is a key regulatory protein participating in cell cycle checkpoint and DNA damage repair networks. BRCA1 plays important roles in protecting numerous cellular processes in response to cell damaging signals. Transforming growth factor-beta (TGF-beta)
Huchun Li, Masayuki Sekine, Seyha Seng, Shalom Avraham, Hava Karsenty Avraham   +4 more
doaj   +1 more source

Functional Restoration of BRCA1 Nonsense Mutations by Aminoglycoside-Induced Readthrough

Frontiers in Pharmacology, 2022
BRCA1 is a major tumor suppressor that functions in the accurate repair of DNA double-strand breaks via homologous recombination (HR). Nonsense mutations in BRCA1 lead to inactive truncated protein products and are associated with high risk of breast and
Renata B. V. Abreu, Thiago T. Gomes, Thales C. Nepomuceno, Thales C. Nepomuceno, Xueli Li, Mateus Fuchshuber-Moraes, Giuliana De Gregoriis, Guilherme Suarez-Kurtz, Alvaro N. A. Monteiro, Marcelo A. Carvalho, Marcelo A. Carvalho   +10 more
doaj   +1 more source

BRCA1 and TOP2A gene amplification and protein expression in four molecular subtypes of breast cancer [PDF]

Archives of Biological Sciences, 2013
We studied TOP2A amplification (using FISH methods), and TOP2A and BRCA1 protein overexpression (immunohistochemistry) in four molecular subtypes of breast cancer. Of 53 patients, 32 showed TOP2A and 38 showed BRCA1 overexpression.
Mitrović Olivera, Mićić Mileva, Čokić V., Koko Vesna, Đikić Dragoslava, Budeč Mirela, Vignjević Sanja, Breković Tijana   +7 more
doaj   +1 more source

Functional analyses of rare germline BRCA1 variants by transcriptional activation and homologous recombination repair assays

BMC Cancer, 2023
Background Damaging alterations in the BRCA1 gene have been extensively described as one of the main causes of hereditary breast and ovarian cancer (HBOC).
Nicola Bassi, Henrikke Nilsen Hovland, Kashif Rasheed, Elisabeth Jarhelle, Nikara Pedersen, Eunice Kabanyana Mchaina, Sara Marie Engelsvold Bakkan, Nina Iversen, Hildegunn Høberg-Vetti, Bjørn Ivar Haukanes, Per Morten Knappskog, Ingvild Aukrust, Elisabet Ognedal, Marijke Van Ghelue   +13 more
doaj   +1 more source

Methylation and protein expression of DNA repair genes: association with chemotherapy exposure and survival in sporadic ovarian and peritoneal carcinomas

Molecular Cancer, 2009
Background DNA repair genes critically regulate the cellular response to chemotherapy and epigenetic regulation of these genes may be influenced by chemotherapy exposure.
Walsh Tom, Garcia Rochelle L, Taniguchi Toshiyasu, Gonzalez Rachel M, Swisher Elizabeth M, Goff Barbara A, Welcsh Piri   +6 more
doaj   +1 more source

Structure-Function Of The Tumor Suppressor BRCA1

Computational and Structural Biotechnology Journal, 2012
BRCA1, a multi-domain protein, is mutated in a large percentage of hereditary breast and ovarian cancers. BRCA1 is most often mutated in three domains or regions: the N-terminal RING domain, exons 11-13, and the BRCT domain.
Serena L. Clark, Ana M. Rodriguez, Russell R. Snyder, Gary D.V. Hankins, Darren Boehning   +4 more
doaj   +3 more sources

Effect of BRCA1 R1325K mutation on proliferation and apoptosis of gallbladder cancer cells

Shanghai Jiaotong Daxue xuebao. Yixue ban, 2023
Objective·To investigate the effects of breast cancer susceptibility gene 1 (BRCA1) R1325K mutation [arginine (R) to lysine (K) mutation at amino acid 1325] on the proliferation and apoptosis of gallbladder cancer cell lines GBC-SD and NOZ.Methods·BRCA1 ...
YANG Jingxiao, JIA Ziyao, WU Wenguang, WU Xiangsong, ZHANG Fei, LI Huaifeng, ZHU Yidi, LI Maolan   +7 more
doaj   +1 more source