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Localization of BRCA1 Protein in Human Breast Cancer Cells
Breast Cancer Research and Treatment, 2003There is still an ongoing debate concerning the cellular localization of BRCA1 protein in breast cancer. To address this question, we compared the localization of BRCA1 protein using several monoclonal (Ab-1) or polyclonal (C20, D20, I20) antibodies under different technical conditions on human breast cancer cell lines.
Monique, Chambon +4 more
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Breast cancer risk and the BRCA1 interacting protein CTIP
Breast Cancer Research and Treatment, 2007Mutations in BRCA1 predispose to breast cancer. CTIP interacts with BRCA1 and so could also be associated with increased risk. We screened CTIP for germline mutations in 210 probands of breast cancer families including 129 families with no mutations in BRCA1 or BRCA2. No coding variants were detected in CTIP, therefore, it is unlikely to be involved in
Kylie L, Gorringe +4 more
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Highlight: BRCA1 and BRCA2 proteins in breast cancer
Microscopy Research and Technique, 2002AbstractHeterozygous carriers of loss‐of‐function germline mutations in the BRCA1 or BRCA2 breast cancer susceptibility genes have a predisposition to breast and ovarian cancer. Multiple functions have been ascribed to the products of these genes, linking them to pathways that inhibit progression to neoplasia.
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Immunohistochemical Loss of BRCA1 Protein in Uterine Serous Carcinoma
International Journal of Gynecological Pathology, 2014Uterine serous carcinoma is a uncommon aggressive variant of endometrial cancer whose biologic origin is unclear. Mutations in p53 and BRCA1 genes play a key role in ovarian serous carcinogenesis. We investigated whether the loss of BRCA1 expression plays a similar role in uterine serous carcinoma.
Jonathan L, Hecht +3 more
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Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2007
Enhanced genomic instability has been recently reported in normal cells derived from BRCA1/2 mutation carriers when placed in vitro in non-physiological stress conditions. We present here original data which help to explain the observed genomic instability.
De Brakeleer, Sylvia +7 more
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Enhanced genomic instability has been recently reported in normal cells derived from BRCA1/2 mutation carriers when placed in vitro in non-physiological stress conditions. We present here original data which help to explain the observed genomic instability.
De Brakeleer, Sylvia +7 more
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Protein–Protein Interaction Inhibitors of BRCA1 Discovered Using Small Molecule Microarrays
2016Microarray screening technology has transformed the life sciences arena over the last decade. The platform is widely used in the area of mapping interaction networks, to molecular fingerprinting and small molecular inhibitor discovery. The technique has significantly impacted both basic and applied research.
Zhenkun, Na +3 more
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BRCA1 protein products: Antibody specificity…
Nature Genetics, 1996C A, Wilson +9 more
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Biological Functions of the BRCA1 Protein
Breast Disease, 1998W H, Lee +3 more
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Biological Functions of the BRCA1 and BRCA2 Proteins
1999Breast cancer is the most commonly diagnosed nondermatologic cancer in women in the United States. It is second only to lung cancer as the most frequent cause of cancer-related deaths in American women. In 1996, the American Cancer Society projected over 184,000 newly diagnosed cases of breast cancer and over 44,000 deaths secondary to invasive breast ...
Helen K. Chew +2 more
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