Results 241 to 250 of about 111,862 (289)

Identification of Genetic Variants Among Breast Cancer Patients and At-Risk Individuals: A Cohort Study in Sri Lanka. [PDF]

Breast Cancer (Auckl)
Yatawara L, Hewavithana B, Ramanayake AP, Wickramasinghe S, Amarasiri M.   +4 more
europepmc   +1 more source

Tyrer-Cuzick Lifetime Risk Is Not Associated With Non-BRCA1/2 Pathogenic Variants for Breast Carcinoma. [PDF]

Breast J
Rao D, Wernecke C, Baron L, Cai S, Beitsch P, Patel R, Whitworth P, Rosen B, Tran NN, Hughes K, Baron PL.   +10 more
europepmc   +1 more source

Reproductive Decision-Making Among BRCA1/2 Pathogenic Variants Carriers and Physicians: Attitudes Toward Preimplantation and Prenatal Genetic Testing. [PDF]

Prenat Diagn
D'Alonzo M, Actis S, Lavalle G, Suraci S, Pace L, Bounous VE, Ferrero A.   +6 more
europepmc   +1 more source

Hereditary ovarian cancer. [PDF]

Discov Oncol
Jurgiel WA, Panasiuk B, Posmyk R.
europepmc   +1 more source

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Roles of BRCA1 and its interacting proteins

BioEssays, 2000
Germline mutations of BRCA1 predispose women to breast and ovarian cancers. BRCA1 contains several functional domains that interact directly or indirectly with a variety of molecules, including tumor suppressors (p53, RB, BRCA2 and ATM), oncogenes (c-Myc, casein kinase II and E2F), DNA damage repair proteins (RAD50 and RAD51), cell-cycle regulators ...
C X, Deng, S G, Brodie
openaire   +2 more sources

Characterization of BRCA1 Protein Product

2000
Abstract : Germline mutations in the BRCA1 tumor suppressor gene have been implicated in hereditary breast and ovarian cancers. As part of our ultimate goal to characterize novel interactions between BRCA1 and other proteins involved in well-defined pathways, we have pursued an area of research that is just beginning to receive a great deal of ...
Michael Press, John J. Park
openaire   +1 more source

Functional Domains of the BRCA1 and BRCA2 Proteins

Journal of Mammary Gland Biology and Neoplasia, 1998
The BRCA1 and BRCA2 genes encode large unrelated proteins that presumably function as tumor suppressors in normal epithelial cells of the breast. However, the primary amino acid sequences of these proteins provide few insights into the mechanisms by which BRCA1 and BRCA2 inhibit tumor development.
R, Baer, W H, Lee
openaire   +2 more sources

Localization of BRCA1 Protein at the Cellular Level

Journal of Mammary Gland Biology and Neoplasia, 1998
Based on its amino acid sequence and the existence of three nuclear localization signal (NLS)3 regions, BRCA1 is likely to be a cell cycle-dependent nuclear protein, regulated by cyclin-dependent kinases (cdk) and associated with nuclear proteins such as Rad51 and BARD1, involved in transcription regulation and participating in DNA replication ...
C R, De Potter, E D, Coene, V R, Schelfhout   +2 more
openaire   +2 more sources

Protein Partners of the BRCA1 Tumor Suppressor

Breast Disease, 1998
The primary amino acid sequence of BRCA1 offers few clues about the mechanism by which it suppresses tumor formation in normal breast and ovarian tissues. In an effort to unravel its biological functions, investigators have sought to identify the proteins that interact with BRCA1 in vivo.
openaire   +2 more sources

Western Analysis of Breast Cancer 1 Protein (BRCA1)

2019
Known for its tumor suppressor activity in breast and ovarian cancers, the breast cancer 1 susceptibility gene (Brca1) is involved in a variety of cellular pathways including DNA repair, antioxidant signaling, apoptosis, and cell cycle regulation. BRCA1 can translocate between the cytoplasm and nucleus to perform its various roles.
Danielle M, Drake, Peter G, Wells
openaire   +2 more sources