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Biological Functions of the BRCA1 and BRCA2 Proteins
1999Breast cancer is the most commonly diagnosed nondermatologic cancer in women in the United States. It is second only to lung cancer as the most frequent cause of cancer-related deaths in American women. In 1996, the American Cancer Society projected over 184,000 newly diagnosed cases of breast cancer and over 44,000 deaths secondary to invasive breast ...
Helen K. Chew +2 more
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Localization of BRCA1 Protein in Human Breast Cancer Cells
Breast Cancer Research and Treatment, 2003There is still an ongoing debate concerning the cellular localization of BRCA1 protein in breast cancer. To address this question, we compared the localization of BRCA1 protein using several monoclonal (Ab-1) or polyclonal (C20, D20, I20) antibodies under different technical conditions on human breast cancer cell lines.
Monique, Chambon +4 more
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Immunohistochemical Loss of BRCA1 Protein in Uterine Serous Carcinoma
International Journal of Gynecological Pathology, 2014Uterine serous carcinoma is a uncommon aggressive variant of endometrial cancer whose biologic origin is unclear. Mutations in p53 and BRCA1 genes play a key role in ovarian serous carcinogenesis. We investigated whether the loss of BRCA1 expression plays a similar role in uterine serous carcinoma.
Jonathan L, Hecht +3 more
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Breast cancer risk and the BRCA1 interacting protein CTIP
Breast Cancer Research and Treatment, 2007Mutations in BRCA1 predispose to breast cancer. CTIP interacts with BRCA1 and so could also be associated with increased risk. We screened CTIP for germline mutations in 210 probands of breast cancer families including 129 families with no mutations in BRCA1 or BRCA2. No coding variants were detected in CTIP, therefore, it is unlikely to be involved in
Kylie L, Gorringe +4 more
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Interaction of BRCA1 with the DNA-Dependent Protein Kinase
2004Abstract : The DNA-dependent protein kinase (DNA-PK) plays a very important role in the repair of DNA double-strand breaks generated by ionizing radiation (IR). The activation of DNA-PK in response to IR involves multiple autophosphorylations at SftQ residues of the catalytic subunit, DNA-PKcs.
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[Isolation and characterization of a BRCA1-interacting protein].
Yi chuan xue bao = Acta genetica Sinica, 2004BRCA1 (breast cancer susceptibility gene-1) plays important roles in DNA damage repair, cell checkpoint regulation, gene transcription, chromosome stability, and apoptosis. At the C-terminus of BRCA1 is the activation domain with a number of acidic amino acid residues that includes two tandem repeats of BRCT(BRCT1 and BRCT2). In this study, to identify
Jing-Hua, Yan +5 more
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Western Analysis of Breast Cancer 1 Protein (BRCA1)
2019Known for its tumor suppressor activity in breast and ovarian cancers, the breast cancer 1 susceptibility gene (Brca1) is involved in a variety of cellular pathways including DNA repair, antioxidant signaling, apoptosis, and cell cycle regulation. BRCA1 can translocate between the cytoplasm and nucleus to perform its various roles.
Danielle M, Drake, Peter G, Wells
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Biological Functions of the BRCA1 Protein
Breast Disease, 1998W H, Lee +3 more
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BRCA1 protein products: Antibody specificity…
Nature Genetics, 1996C A, Wilson +9 more
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