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Computational structural assessment of BReast CAncer type 1 susceptibility protein (BRCA1) and BRCA1-Associated Ring Domain protein 1 (BARD1) mutations on the protein-protein interface

Advances in Protein Chemistry and Structural Biology, 2022
Breast cancer type 1 susceptibility protein (BRCA1) is closely related to the BRCA2 (breast cancer type 2 susceptibility protein) and BARD1 (BRCA1-associated RING domain-1) proteins.
S Udhaya Kumar, Nikita Jain, Balu Kamaraj   +2 more
exaly   +2 more sources

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Localization of BRCA1 Protein at the Cellular Level

Journal of Mammary Gland Biology and Neoplasia, 1998
Based on its amino acid sequence and the existence of three nuclear localization signal (NLS)3 regions, BRCA1 is likely to be a cell cycle-dependent nuclear protein, regulated by cyclin-dependent kinases (cdk) and associated with nuclear proteins such as Rad51 and BARD1, involved in transcription regulation and participating in DNA replication ...
C R, De Potter, E D, Coene, V R, Schelfhout   +2 more
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Roles of BRCA1 and its interacting proteins

BioEssays, 2000
Germline mutations of BRCA1 predispose women to breast and ovarian cancers. BRCA1 contains several functional domains that interact directly or indirectly with a variety of molecules, including tumor suppressors (p53, RB, BRCA2 and ATM), oncogenes (c-Myc, casein kinase II and E2F), DNA damage repair proteins (RAD50 and RAD51), cell-cycle regulators ...
C X, Deng, S G, Brodie
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Functional Domains of the BRCA1 and BRCA2 Proteins

Journal of Mammary Gland Biology and Neoplasia, 1998
The BRCA1 and BRCA2 genes encode large unrelated proteins that presumably function as tumor suppressors in normal epithelial cells of the breast. However, the primary amino acid sequences of these proteins provide few insights into the mechanisms by which BRCA1 and BRCA2 inhibit tumor development.
R, Baer, W H, Lee
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Protein Partners of the BRCA1 Tumor Suppressor

Breast Disease, 1998
The primary amino acid sequence of BRCA1 offers few clues about the mechanism by which it suppresses tumor formation in normal breast and ovarian tissues. In an effort to unravel its biological functions, investigators have sought to identify the proteins that interact with BRCA1 in vivo.
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Regulation of PCTAIRE1 protein stability by AKT1, LKB1 and BRCA1

Cellular Signalling, 2021
PCTAIRE1, also known as CDK16, is a cyclin-dependent kinase that is regulated by cyclin Y. It is a member of the serine-threonine family of kinases and its functions have primarily been implicated in cellular processes like vesicular transport, neuronal growth and development, myogenesis, spermatogenesis and cell proliferation.
Syed Qaaifah, Gillani, Misbah Un, Nisa, Zarka, Sarwar, Irfana, Reshi, Sameer Ahmed, Bhat, Nusrat, Nabi, Shaida, Andrabi   +6 more
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Characterization of BRCA1 Protein Product

2000
Abstract : Germline mutations in the BRCA1 tumor suppressor gene have been implicated in hereditary breast and ovarian cancers. As part of our ultimate goal to characterize novel interactions between BRCA1 and other proteins involved in well-defined pathways, we have pursued an area of research that is just beginning to receive a great deal of ...
Michael Press, John J. Park
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Highlight: BRCA1 and BRCA2 proteins in breast cancer

Microscopy Research and Technique, 2002
AbstractHeterozygous carriers of loss‐of‐function germline mutations in the BRCA1 or BRCA2 breast cancer susceptibility genes have a predisposition to breast and ovarian cancer. Multiple functions have been ascribed to the products of these genes, linking them to pathways that inhibit progression to neoplasia.
openaire   +2 more sources