Results 21 to 30 of about 68,702 (192)

In Vitro Enhanced Sensitivity to Cisplatin in D67Y BRCA1 RING Domain Protein

Breast Cancer: Basic and Clinical Research, 2011
BRCA1 is a tumor suppressor protein involved in maintaining genomic integrity through multiple functions in DNA damage repair, transcriptional regulation, cell cycle checkpoint, and protein ubiquitination. The BRCA1-BARD1 RING complex has an E3 ubiquitin
Apichart Atipairin, Adisorn Ratanaphan
doaj   +1 more source

Hybrid-seq deciphers the complex transcriptional profile of the human BRCA1 DNA repair associated gene

RNA Biology, 2023
Breast Cancer Gene 1 (BRCA1) is a tumour suppressor protein that modulates multiple biological processes including genomic stability and DNA damage repair.
Panagiotis G. Adamopoulos, Konstantina Athanasopoulou, Michaela A. Boti, Georgios Dimitroulis, Glykeria N. Daneva, Panagiotis Tsiakanikas, Andreas Scorilas   +6 more
doaj   +1 more source

Characterization of a carboxy-terminal BRCA1 interacting protein [PDF]

Oncogene, 1998
There are several lines of evidence indicating that the carboxy-terminal region of the tumor suppressor protein BRCA1 is a functionally significant domain. Using the yeast two-hybrid and in vitro biochemical assays, we show that a protein, CtIP, interacts specifically with the carboxy-terminal segment of human BRCA1 from residues 1602-1863. A germ line
A K, Wong, P A, Ormonde, R, Pero, Y, Chen, L, Lian, G, Salada, S, Berry, Q, Lawrence, P, Dayananth, P, Ha, S V, Tavtigian, D H, Teng, P L, Bartel   +12 more
openaire   +2 more sources

European guidelines from the EHTG and ESCP for Lynch syndrome: an updated third edition of the Mallorca guidelines based on gene and gender

BJS (British Journal of Surgery), EarlyView., 2020
Recommendations for clinical and molecular identification of LS, surgical and endoscopic management of LS‐associated colorectal cancer and preventive measures for cancer were produced. The emphasis was on surgical and gastroenterological aspects of the cancer spectrum.
T. T. Seppälä, A. Latchford, I. Negoi, A. Sampaio Soares, R. Jimenez‐Rodriguez, L. Sánchez‐Guillén, D. G. Evans, N. Ryan, E. J. Crosbie, M. Dominguez‐Valentin, J. Burn, M. Kloor, M. von Knebel Doeberitz, F. J. B. van Duijnhoven, P. Quirke, J. R. Sampson, P. Møller, G. Möslein, on behalf of the European Hereditary Tumour Group (EHTG) and European Society of Coloproctology (ESCP)   +18 more
wiley   +1 more source

BRCA1 and Its Network of Interacting Partners

Biology, 2013
BRCA1 is a large multi-domain protein with a pivotal role in maintaining genome stability and cell cycle progression. Germline mutations in the BRCA1 gene confer an estimated lifetime risk of 60%–80% for breast cancer and 15%–60% for ...
Kyriacos Kyriacou, Charita M. Christou
doaj   +1 more source

Uncovering the Translational Regulatory Activity of the Tumor Suppressor BRCA1

Cells, 2020
BRCA1 inactivation is a hallmark of familial breast cancer, often associated with aggressive triple negative breast cancers. BRCA1 is a tumor suppressor with known functions in DNA repair, transcription regulation, cell cycle control, and apoptosis.
Elise Berthel, Anne Vincent, Lauriane Eberst, Adrian Gabriel Torres, Estelle Dacheux, Catherine Rey, Virginie Marcel, Hermes Paraqindes, Joël Lachuer, Frédéric Catez, Lluis Ribas de Pouplana, Isabelle Treilleux, Jean-Jacques Diaz, Nicole Dalla Venezia   +13 more
doaj   +1 more source

Decapping protein EDC4 regulates DNA repair and phenocopies BRCA1 [PDF]

Nature Communications, 2018
AbstractBRCA1 is a tumor suppressor that regulates DNA repair by homologous recombination. Germline mutations in BRCA1 are associated with increased risk of breast and ovarian cancer and BRCA1 deficient tumors are exquisitely sensitive to poly (ADP-ribose) polymerase (PARP) inhibitors.
Gonzalo Hernández, María José Ramírez, Jordi Minguillón, Paco Quiles, Gorka Ruiz de Garibay, Miriam Aza-Carmona, Massimo Bogliolo, Roser Pujol, Rosario Prados-Carvajal, Juana Fernández, Nadia García, Adrià López, Sara Gutiérrez-Enríquez, Orland Diez, Javier Benítez, Mónica Salinas, Alex Teulé, Joan Brunet, Paolo Radice, Paolo Peterlongo, Detlev Schindler, Pablo Huertas, Xose S Puente, Conxi Lázaro, Miquel Àngel Pujana, Jordi Surrallés   +25 more
openaire   +13 more sources

ZNF121 interacts with ZBRK1 and BRCA1 to regulate their target genes in mammary epithelial cells

FEBS Open Bio, 2018
The novel zinc finger protein 121 (ZNF121) has been demonstrated to physically and functionally associate with the MYC oncoprotein to regulate cell proliferation and likely breast cancer development.
Ang Luo, Kailun Zhang, Yanxia Zhao, Zhengmao Zhu, Liya Fu, Jin‐Tang Dong   +5 more
doaj   +1 more source

A high-throughput approach to identify BRCA1-downregulating compounds to enhance PARP inhibitor sensitivity

iScience
Summary: PARP inhibitors (PARPi) are efficacious in BRCA1-null tumors; however, their utility is limited in tumors with functional BRCA1. We hypothesized that pharmacologically reducing BRCA1 protein levels could enhance PARPi effectiveness in BRCA1 wild-
Erin Sellars, Margarita Savguira, Jie Wu, Sabrina Cancelliere, Mark Jen, Rehna Krishnan, Anne Hakem, Dalia Barsyte-Lovejoy, Razqallah Hakem, Steven A. Narod, Joanne Kotsopoulos, Leonardo Salmena   +11 more
doaj   +1 more source

Data from BRCA1-Associated Protein 1 Interferes with BRCA1/BARD1 RING Heterodimer Activity

, 2023
<div>Abstract<p>The breast and ovarian tumor suppressor BRCA1 constitutes a RING heterodimer E3 ligase with BARD1. BRCA1-associated protein 1 (BAP1) is a ubiquitin COOH-terminal hydrolase that was initially identified as a protein that bound to the RING finger domain of BRCA1.
Tomohiko Ohta, Mamoru Fukuda, Hiromichi Gomi, Ryoko Kojima, Ayaka Koike, Wenwen Wu, Hiroyuki Nishikawa   +6 more
openaire   +1 more source