Results 101 to 110 of about 104,745 (290)

Should MRI replace mammography as the initial screening modality for asymptomatic women aged 18 – 45 years at high risk of developing breast cancer? A systematic review

Asian Journal of Medical Sciences, 2016
Background: Breast cancer occurs in both men and women, although it is more prevalent among women. Mammography is generally the diagnostic imaging modality of choice, but it is limited in the detection of breast cancer in young women, aged 18-45 years ...
GM Akpaniwo
doaj   +1 more source

BƯỚC ĐẦU KHẢO SÁT ĐỘT BIẾN GEN BRCA1 VÀ BRCA2 T RONG QUẦN THỂ UNG THƯ BIỂU MÔ BUỒNG TRỨNG NGƯỜI VIỆT NAM BẰNG KỸ THUẬT GIẢI TRÌNH TỰ THẾ HỆ MỚI

Tạp chí Khoa học Đại học Huế: Khoa học Tự nhiên, 2020
BRCA1 và BRCA2 là hai gen ức chế khối u quan trọng. Việc đột biến hai gen này ở bệnh nhân ung thư biểu mô buồng trứng dòng mầm và dòng sinh dưỡng thì đáp ứng tốt hơn với thuốc ức chế enzyme poly(ADP-ribose) polymerase inhibitor (PARPi).
Ngo Dai Phu, Ngo Vinh Tuong, Pham Huy Hoa, Bui Thi Hong Nhu, Vo Thanh Nhan, Le Quang Thanh, Le Thai Khương, Hoang Anh Vu, Nguyen Duy Sinh, Hoang Thanh Chi, Nguyen Dang Quan, Nguyen Trong Binh   +11 more
doaj   +1 more source

Is Lactate an Oncometabolite? Evidence Supporting a Role for Lactate in the Regulation of Transcriptional Activity of Cancer-Related Genes in MCF7 Breast Cancer Cells. [PDF]

, 2019
Lactate is a ubiquitous molecule in cancer. In this exploratory study, our aim was to test the hypothesis that lactate could function as an oncometabolite by evaluating whether lactate exposure modifies the expression of oncogenes, or genes encoding ...
Brooks, George A, Julian, Colleen G, Martinez, Janel, Matarazzo, Christopher, San-Millán, Iñigo   +4 more
core   +1 more source

What Happens After Menopause (WHAM)? A Progress Report of a Prospective Controlled Study of Women After Pre‐Menopausal Risk‐Reducing Bilateral Salpingo‐Oophorectomy

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Surgical menopause, the removal of both ovaries prior to natural menopause, may impact short‐and long‐term physical and emotional health. An increasingly common cause of surgical menopause is risk‐reducing salpingo‐oophorectomy (RRSO) in those at high inherited risk of ovarian cancer.
Sarah A. L. Price, Pauline M. Maki, Samar R. El Khoudary, Alison Brand, Rakibul M. Islam, Susan M. Domchek, Hadine Joffe, Gita D. Mishra, Katrina M. Moss, Fiona C. Baker, Sabine Braat, John D. Wark, Martha Hickey   +12 more
wiley   +1 more source

Population testing for cancer predisposing BRCA1/BRCA2 mutations [PDF]

, 2014
Background: Technological advances raise the possibility of systematic population-based genetic testing for cancer-predisposing mutations, but it is uncertain whether benefits outweigh disadvantages.
Wardle, J
core  

Dynamic cluster-scaling in DNA

, 2010
It is shown that the nucleotide sequences in DNA molecules have cluster-scaling properties (discovered for the first time in turbulent processes: Sreenivasan and Bershadskii, 2006, J. Stat. Phys., 125, 1141-1153.).
A. Bershadskii, Ambjornsson, Bershadskii, Blow, Campa, Conti, Cule, Dauxois, Hennig, Hyrien, Jeon, Joyeux, Jun, Krueger, Li, Mesner, Peyrard, Podobnik, Rhind, Saenger, Shechter, Sponer, Sreenivasan, Stanley, Voss, Yang   +25 more
core   +1 more source

Sexual Function, Activity and Distress 24 Months After Surgical Menopause: What Happens After Menopause (WHAM)—A Prospective Controlled Study

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective To determine the effect of surgical menopause (risk‐reducing salpingo‐oophorectomy, RRSO) on sexual function and the modifying effects of HRT. Design Prospective observational study of women undergoing RRSO and age‐matched comparison group who retained their ovaries. Setting High‐risk clinics and general population.
Martha Hickey, Trevor Tejada‐Berges, Susan M. Domchek, Efrosinia O. Krejany, Alison Brand, Peixuan Li, Sabine Braat, Sheryl Kingsberg   +7 more
wiley   +1 more source

Inflammation targets specific organs for cancer in carriers of BRCA1/2 pathway mutations [PDF]

, 2010
Women who inherit a defective BRCA1 or BRCA2 gene have risks for breast/ovarian cancer that are so high and apparently so selective that many mutation carriers choose to have the most likely targets for cancer surgically removed.
Bernard Friedenson
core   +1 more source

Development and Real‐World Evaluation of a Statewide Mainstream Model of Germline Genetic Testing for BRCA1/2 and Mismatch Repair Gene Variants (Lynch Syndrome)

Asia-Pacific Journal of Clinical Oncology, EarlyView.
This translational quality improvement study evaluated a statewide pathway for mainstream genetic testing in South Australia. Adoption of mainstream BRCA1/2 testing increased significantly, but not MMR testing. Findings highlight the need for tailored, context‐specific strategies to integrate genetic testing into routine care across diverse cancer ...
Cally A. Jennings, Kathryn Cornthwaite, Michael Osborn, Ganessan Kichenadasse, Eryn Dow   +4 more
wiley   +1 more source

Carrier screening program for BRCA1/BRCA2 pathogenic variants among Ashkenazi Jewish women in Israel: An observational study

, 2023
Rotem Greenberg, Efrat Aharonov‐Majar, Ofer Isakov, Samah Hayek, Naama Elefant, Ran D. Balicer, Adi Berliner Senderey, Shay Ben‐Shachar   +7 more
openalex   +1 more source