Results 151 to 160 of about 60,203 (254)

Prevalence of Novel and Recurrent Pathogenic Variants in BRCA Genes in a Cohort of Iranian Hereditary Breast Cancer Patients

Advanced Biomedical Research
Background: The incidence of breast cancer (BC) is increasing in Iranian women, especially in those with a positive family history of any type of cancer. Being a carrier of pathogenic variants in BRCA1/2 genes, significantly raises the risk of developing
Akram Sarmadi, Shaghayegh Haghjooy Javanmard, Mehrdad Zeinalian, Majid Hosseinzadeh, Mohammad Amin Tabatabaiefar   +4 more
doaj   +1 more source

Association Between Germline BRCA1/2 Gene Variants and Clinicopathological Features of Ovarian Cancer

International Journal of General Medicine
Yu Luo,1,2 Ru Pan,1,2 Hui Rao,2,3 Xing Chen,4 Haikun Yang1,2 1Department of Gynaecology, Meizhou People’s Hospital, Meizhou Academy of Medical Sciences, Meizhou, People’s Republic of China; 2Meizhou Municipal Engineering and Technology Research Center ...
Luo Y, Pan R, Rao H, Chen X, Yang H
doaj  

Встречаемость мутаций в генах BRCA1 и BRCA2 у больных раком поджелудочной железы

, 2016
BRCA1 and BRCA2 may contribute in pancreatic cancer (PC) risk, however the selection criteria for BRCA1 testing are poorly defined. The analysis of Russian founder mutation BRCA1 5382insC in 150 PC patients identified 2 carriers.
L. D. Roman, А. К. Иванова, A. A. Kashintsev, Е. Н. Суспицин, M. S. Dinikin, А. Г. Иевлева, Н. М. Волков, А. В. Того, М. С. Диникин, A. P. Sokolenko, Г. А. Янус, A. V. Togo, Н. Ю. Коханенко, A. I. Budovskiy, В. М. Моисеенко, V. M. Moiseenko, K. G. Shostko, E. N. Imyanitov, К. Г. Шостко, G. A. Yanus, E. N. Suspitsin, А. И. Будовский, A. G. Ievleva, R. V. Fadeev, М. Д. Ханевич, N. Yu. Kokhanenko, N. M. Volkov, А. П. Соколенко, Р. В. Фадеев, Е. Н. Имянитов, M. D. Hanevich, A. K. Ivanova, А. А. Кашинцев, Л. Д. Роман   +33 more
core  

A theory for the tissue specificity of BRCA1/2 related and other hereditary cancers

, 2010
Women who inherit a defective BRCA1 or BRCA2 gene have risks for breast and ovarian cancer that are so high and seem so selective that many mutation carriers choose to have prophylactic surgery. There has been much conjecture to explain such apparently
Bernard Friedenson
core  

BRCA2 in abscission [PDF]

Nature Cell Biology, 2012
openaire   +1 more source

Germline BRCA1 and BRCA2 deleterious mutations and variants of unknown clinical significance associated with breast/ovarian cancer: a report from North India

, 2018
Anurag Mehta,1 Smreti Vasudevan,2 Sanjeev Kumar Sharma,1 Dushyant Kumar,1 Manoj Panigrahi,1 Moushumi Suryavanshi,1 Garima Gupta2 1Department of Laboratory and Transfusion Services, Rajiv Gandhi Cancer Institute and Research Centre, Rohini, Delhi 110085 ...
Kumar D, Sharma SK, Mehta A, Gupta G, Panigrahi M, Vasudevan S, Suryavanshi M   +6 more
core  

Silencing of BRCA2 to Identify Novel BRCA2-regulated Biological Functions in Cultured Human Cells

, 2015
Silencing of the tumor suppressor protein BRCA2 and its detection by conventional biochemical analyses represent a great technical challenge owing to the large size of the human BRCA2 protein (approximately 390 kDa).
Giannattasio S., Guaragnella N, Moro L
core  

Gastric Epithelium from BRCA1 and BRCA2 Carriers Harbors Increased Double-Stranded DNA Damage and Enhanced Growth Potential. [PDF]

Mol Cancer Res
Buckley KH, Dungan ME, Dinh K, Kelly GM, Hausler R, Bennett KE, Clay DG, Youngman JE, Majer AD, Beyries KA, Niccum BA, Shaffer SM, Karakasheva TA, Hamilton KE, Kochman ML, Ginsberg GG, Ahmad N, Maxwell KN, Katona BW.   +18 more
europepmc   +1 more source

Contralateral breast cancer risks for BRCA1, BRCA2, PALB2, CHEK2, and ATM pathogenic variant carriers in two large cohort studies. [PDF]

BJC Rep
Allen I, Whish N, Yadav S, Boddicker NJ, Drukker C, van de Beek I, Eccles DM, Turnbull C, Pharoah P, Antoniou AC, Easton DF, Couch FJ, Schmidt MK, Tischkowitz M.   +13 more
europepmc   +1 more source

Exon-Specific Targeted Analysis of <i>BRCA1</i> and <i>BRCA2</i> Mutations in Bangladeshi Breast Cancer Patients. [PDF]

Cancer Inform
Dutta S, Rashid SMM, Islam S, Ahmed SF, Ayub M.   +4 more
europepmc   +1 more source