Results 151 to 160 of about 65,232 (224)

High‐Content CRISPR Screening: Methods and Applications

MedComm, Volume 7, Issue 9, September 2026.
High‐content CRISPR screening represents a paradigm shift in functional genomics, moving beyond traditional survival‐based readouts to enable multidimensional mapping of genotype–phenotype relationships. This review systematically outlines the methodological evolution of this approach, detailing advances in perturbation modalities, delivery systems ...
Yike Zhang, Yimeng Zhang, Xudong Tang, Xinyu Deng, Yitian Zhou, Yanfeng Wu, Jianhua Luo   +6 more
wiley   +1 more source

Comprehensive Genomic Profiling Reveals the Mutational Spectrum and Clinical Significance of BRCA1/2 and Other Cancer-Susceptibility Genes in Breast Cancer Patients from Southern Tunisia. [PDF]

Cancers (Basel)
Ammous-Boukhris N, Abdelmaksoud-Dammak R, Ben Kridis W, Ben-Ayed-Guerfali D, Guidara S, Feki A, Kamoun H, Khanfir A, Daoud J, Lizard GH, Gargouri A, Mokdad-Gargouri R.   +11 more
europepmc   +1 more source

Prostate Cancer Development, Progression, and Therapy

MedComm – Oncology, Volume 5, Issue 3, September 2026.
This review provides an integrated overview of prostate cancer development, progression, and therapy, spanning historical milestones, molecular mechanisms, advanced research models, and emerging therapeutic strategies. It highlights recent advances in precision diagnosis, lineage plasticity, therapy resistance, and next‐generation treatments for ...
Xin Jin, Zicheng Xiao, Zexian Ding, Wei Li, Ruijiang Zeng, Yujun Shuai, Weimin Ci, Dan Xia, Xu Zhang, Haojie Huang   +9 more
wiley   +1 more source

Overcoming Resistance to PARP Inhibitors in BRCA-Mutated Cancers: Mechanisms and Therapeutic Strategies. [PDF]

J Cancer
Guo J, Wang Y, Li J, Jiang Z.
europepmc   +1 more source

Is There Potential Clinical Utility in Reporting Variants of Uncertain Significance From Prenatal Sequencing?

Prenatal Diagnosis, Volume 46, Issue 10, Page 1557-1564, September 2026.
ABSTRACT Objective Prenatal sequencing of fetuses with abnormalities detected on imaging is expanding globally. Debate continues over whether variants of uncertain significance (VUS) should be reported prenatally, with some recent national position statements opposing this.
A. Gibbs, R. Braham, V. Ramachandran, R. Roberts, C. Willison, T. Ashraf, J. Cobben, A. Gardham, M. Holder‐Espinasse, T. Homfray, S. G. Mehta, D. Tapon, P. Vasudevan, N. J. Chandler   +13 more
wiley   +1 more source

CHK2 regulates MUS81-dependent DSBs in response to replication stress and BRCA2 deficiency. [PDF]

Nucleic Acids Res
Malacaria E, Figlioli C, Palma A, Honda M, Valenzisi P, Casella M, Camerini S, Pucci F, Rinalducci S, Semproni M, Spies M, Franchitto A, Pichierri P.   +12 more
europepmc   +1 more source

Prenatally diagnosed cleft lip and palate: Prenatal findings, clinical outcomes, genetic results, and sequencing yield in isolated versus non‐isolated cases

Pregnancy, Volume 2, Issue 5, September 2026.
Abstract Introduction Cleft lip and palate (CLP) are common congenital disruptions of the orofacial cleft and are associated with numerous genetic conditions. This study examines prenatal findings, clinical outcomes, and genetic findings among prenatally diagnosed CLP, with a focus on the yield of next‐generation sequencing (NGS).
Thomas P. Kishkovich, Gabriela F. Tessler, Meghan Angley, Yijia Zhang, Thomas A. Imahiyerobo, Sherelle L. Laifer‐Narin, Hong Ma, Lynn Simpson, Caitlin D. Baptiste, Jessica L. Giordano, Russell S. Miller, Ronald J. Wapner   +11 more
wiley   +1 more source

Functional characterization of BRCA2 variants of uncertain significance identified in Korean breast cancer patients. [PDF]

Breast Cancer
Lim AR, Jung SP, Kim K, Choi HJ, Park KH, Lee S.   +5 more
europepmc   +1 more source

Intelligent nano‐platforms in breast cancer therapy: Current advances and future perspectives

Precision Medical Sciences, Volume 15, Issue 3, Page 194-205, September 2026.
The smart nano platform in breast cancer treatment is designed with advanced nanocarriers, including liposomes, hydrogels, porous nanoparticles, and aptamer‐based systems. These systems are capable of targeted drug release and response to environmental stimuli.
Tina Rahimi, Moluk Aivazi
wiley   +1 more source

Impact of BRCA2 pathogenic variants on outcomes to first-line CDK4/6 inhibitors plus endocrine therapy in HR-positive/HER2-negative metastatic breast cancer. [PDF]

ESMO Open
Cruellas M, Rodriguez-Hernandez A, Carità L, Seguí E, Cejuela M, Lema L, García-Torralba E, Roqué-Lloveras A, Fernández-Ortega A, Melé M, Tapia M, Servitja S, González-Santiago S, Blaya-Boluda N, Bellet M, Martínez-Sáez O, Pimentel I, García-Fructuoso I, Pascual T, Joval-Ramentol L, Viñas G, Rey Aceituno M, Casas A, Castillo E, Brasó-Maristany F, Vivancos A, Serra V, Villacampa G, Oliveira M, Prat A, Saura C, Adamo B, Balmaña J.   +32 more
europepmc   +1 more source