Results 211 to 220 of about 60,203 (254)
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Current Problems in Cancer, 2014
A hereditary breast cancer syndrome can present in a variety of ways ranging from an index case of early-onset breast cancer to an incidental finding during an endoscopy or a dermatological examination. A comprehensive review of the patient’s personal and family history is essential to accurately assess the risk for a hereditary cancer syndrome ...
Kimberly, King-Spohn, Robert, Pilarski
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A hereditary breast cancer syndrome can present in a variety of ways ranging from an index case of early-onset breast cancer to an incidental finding during an endoscopy or a dermatological examination. A comprehensive review of the patient’s personal and family history is essential to accurately assess the risk for a hereditary cancer syndrome ...
Kimberly, King-Spohn, Robert, Pilarski
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International Journal of Gastrointestinal Cancer, 2002
Many factors, including a family history of cancer, have been implicated in the development of pancreatic cancer. Among these factors, germline BRCA2 mutations have been clearly associated with the development of this disease, while mutations in BRCA1 appear to have a limited role. Patients with pancreatic cancer and germline BRCA2 mutations tend to be
Ali, Naderi, Fergus J, Couch
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Many factors, including a family history of cancer, have been implicated in the development of pancreatic cancer. Among these factors, germline BRCA2 mutations have been clearly associated with the development of this disease, while mutations in BRCA1 appear to have a limited role. Patients with pancreatic cancer and germline BRCA2 mutations tend to be
Ali, Naderi, Fergus J, Couch
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Functions of the BRCA1 and BRCA2 genes
Current Opinion in Genetics & Development, 1998Mutations in the BRCA1 and BRCA2 genes confer a high risk of breast cancer development. Both genes encode very large proteins of unknown function but recent results suggest that they may have roles in transcriptional regulation and DNA repair. These advances offer the prospect of understanding not only the normal cellular function of these genes but ...
D, Bertwistle, A, Ashworth
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BRCA1 and BRCA2 in breast cancer
Breast Cancer Research and Treatment, 1999Breast cancer, one of the most common serious malignancies affecting women, occurs in hereditary and sporadic forms. Hereditary breast cancer accounts for 5-10% of all cases and has some distinctive clinical features compared with sporadic breast cancer.
X, Yang, M E, Lippman
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Structural insights into BRCA2 function
Current Opinion in Structural Biology, 2003BRCA2 is a tumor suppressor directly implicated in familial breast cancer. Extensive genetic and biochemical characterization has shown that BRCA2 is involved in the maintenance of chromosomal stability and that it has an important role in recombination-mediated double-strand DNA break repair.
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