Results 201 to 210 of about 44,419 (235)
Hormone Therapy After Oophorectomy and Breast Cancer Risk in Women With BRCA Pathogenic Variant.
JAMA Netw OpenRegev-Sadeh S +9 more
europepmc +1 more source
Suppression of polyploidy by the BRCA2 protein
Cancer Letters, 2007 Mounting evidence implicates BRCA2 not only in maintenance of genome integrity but also in cell-cycle checkpoints. However, the contribution of BRCA2 in the checkpoints is still far from being understood. Here, we demonstrate that breast cancer cells MX-1 are unable to maintain genome integrity, which results in gross polyploidization.
Evgeny Sagulenko +2 more
exaly +7 more sources
Cancer-causingBRCA2missense mutations disrupt an intracellular protein assembly mechanism to disable genome maintenance [PDF]
Nucleic Acids Research, 2021 Cancer-causing missense mutations in the 3418 amino acid BRCA2 breast and ovarian cancer suppressor protein frequently affect a short (∼340 residue) segment in its carboxyl-terminal domain (DBD).
David Shorthouse +2 more
exaly +2 more sources
Interaction between BRCA2 and replication protein A is compromised by a cancer-predisposing mutation in BRCA2 [PDF]
Oncogene, 2003 Mutations in the BRCA1 and BRCA2 genes predispose women to familial, early-onset breast cancer. Both the BRCA1 and BRCA2 proteins appear to function in the homologous recombination pathway of DNA double-strand break repair. Both BRCA1 and BRCA2 have also been implicated in transcription by RNA polymerase II, for both proteins have domains which, when ...
C James Ingles
exaly +3 more sources
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A kinetoplastid BRCA2 interacts with DNA replication protein CDC45
International Journal for Parasitology, 2009The gene BRCA2, first identified as a breast cancer susceptibility locus in humans, encodes a protein involved in DNA repair in mammalian cells and mutations in this gene confer increased risk of breast cancer. Here we report a functional characterisation of a Trypanosoma brucei BRCA2 (TbBRCA2) orthologue and show that the protein interacts directly ...
Samuel O Oyola, Frédéric Bringaud
exaly +3 more sources
Functional Domains of the BRCA1 and BRCA2 Proteins
Journal of Mammary Gland Biology and Neoplasia, 1998The BRCA1 and BRCA2 genes encode large unrelated proteins that presumably function as tumor suppressors in normal epithelial cells of the breast. However, the primary amino acid sequences of these proteins provide few insights into the mechanisms by which BRCA1 and BRCA2 inhibit tumor development.
R, Baer, W H, Lee
openaire +2 more sources
Nuclear Localization Signals of the BRCA2 Protein
Biochemical and Biophysical Research Communications, 2000BRCA2 is a tumor suppressor gene whose germline mutations increase the lifetime risk of breast cancer. BRCA2 encodes a large nuclear protein involved in DNA repair, but the location of its functional domain has been unclear. Here, we report nuclear localization signals (NLSs) of the BRCA2 protein.
K, Yano +5 more
openaire +2 more sources
Abnormal Cytokinesis in Cells Deficient in the Breast Cancer Susceptibility Protein BRCA2
Science, 2004 Germ-line mutations inactivating BRCA2 predispose to cancer. BRCA2-deficient cells exhibit alterations in chromosome number (aneuploidy), as well as structurally aberrant chromosomes. Here, we show that BRCA2 deficiency impairs the completion of cell division by cytokinesis.
Ashok R Venkitaraman
exaly +4 more sources
Highlight: BRCA1 and BRCA2 proteins in breast cancer
Microscopy Research and Technique, 2002AbstractHeterozygous carriers of loss‐of‐function germline mutations in the BRCA1 or BRCA2 breast cancer susceptibility genes have a predisposition to breast and ovarian cancer. Multiple functions have been ascribed to the products of these genes, linking them to pathways that inhibit progression to neoplasia.
openaire +2 more sources
Biological Functions of the BRCA1 and BRCA2 Proteins
1999Breast cancer is the most commonly diagnosed nondermatologic cancer in women in the United States. It is second only to lung cancer as the most frequent cause of cancer-related deaths in American women. In 1996, the American Cancer Society projected over 184,000 newly diagnosed cases of breast cancer and over 44,000 deaths secondary to invasive breast ...
Helen K. Chew +2 more
openaire +1 more source