Results 141 to 150 of about 19,105 (226)
Multiple roles of Brd4 in the human papillomavirus life cycle
, 2014 While human papillomavirus (HPV) vaccines protect against acquiring new infections, there is currently no antiviral treatment for eradicating persistent HPV infections.
Helfer, Christine M +1 more
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IDENTIFICATION OF POTENT BROMODOMAIN4 (BRD4) INHIBITORS BY ENERGY-PHARMACOPHORE BASED VIRTUAL SCREENING TO TARGET BRD4-NUT MIDLINE CARCINOMA [PDF]
, 2015 Objective: Protein-protein interactions (PPI\u27s) have been used as a target in various diseases. One such major role of PPI\u27s comes when the protein Bromodomain4 (BRD4) reads the epigenetic changes in the histones and regulates transcription.
Ampasala, Dinakara Rao +2 more
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Experimental and Molecular MedicineBrominated domain protein 4 (BRD4) is a chromatin reader known to exacerbate the inflammatory response in post-traumatic osteoarthritis (PTOA) by controlling the expression of inflammatory cytokines. However, the extent to which this regulatory effect is
Ding Zhou +3 more
doaj +1 more source
The Regulation of BRD4 in Transcription and DNA Repair
The DNA damage response (DDR) is crucial for maintaining genomic stability and integrity. The epigenetic reader BRD4 acts as a molecular scaffold and is a key regulator of both transcription and DNA repair.
Lin, Baicheng
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Inhibitors of BRD4 as Potential Cancer Therapy [PDF]
ACS Medicinal Chemistry Letters, 2016 openaire +2 more sources
Targeting BRD2 and BRD4 inhibit the growth of KSHV-infected immortalized endothelial cells through suppression of LANA translation. [PDF]
PLoS PathogChen J +6 more
europepmc +1 more source