Results 121 to 130 of about 20,494 (185)

BRD proteins in human retroviral infection: emerging evidence from HIV-1 and future perspectives for HTLV-1. [PDF]

Mol Biol Rep
Akbarin MM, Farjami Z, Álvarez HR.
europepmc   +1 more source

IDENTIFICATION OF POTENT BROMODOMAIN4 (BRD4) INHIBITORS BY ENERGY-PHARMACOPHORE BASED VIRTUAL SCREENING TO TARGET BRD4-NUT MIDLINE CARCINOMA

, 2015
Objective: Protein-protein interactions (PPI\u27s) have been used as a target in various diseases. One such major role of PPI\u27s comes when the protein Bromodomain4 (BRD4) reads the epigenetic changes in the histones and regulates transcription.
Ampasala, Dinakara Rao, Devi, Sapam Tuleshwori, Tandon, Himani   +2 more
core  

Fragment-Based Discovery of BRD4-BD2 Selective Binders: Biophysical Validation and Structural Insights for Domain-Selective Inhibitor Design. [PDF]

ACS Omega
Baskaran SP, Subramani YV, Bairy SG, Prasad TK, Kumar V, Sridhar A, Padmanabhan B, Kamariah N.   +7 more
europepmc   +1 more source

Bridging BET bromodomain and immune checkpoint inhibitors through generative bioorganic frameworks for next-generation cancer immunotherapy. [PDF]

RSC Med Chem
Diab MK, Yassen ASA, Fahmy SA, Ashour HF, Nafie MS.   +4 more
europepmc   +1 more source

The Regulation of BRD4 in Transcription and DNA Repair

The DNA damage response (DDR) is crucial for maintaining genomic stability and integrity. The epigenetic reader BRD4 acts as a molecular scaffold and is a key regulator of both transcription and DNA repair.
Lin, Baicheng
core  

Cell type-selective targeting by heterobifunctional protein binders via in-cell enrichment. [PDF]

Nat Commun
Bulldan A, Zheng M, Meyners C, Purder PL, Krieger J, Dreizler JK, Geiger TM, Repity ML, Lein MH, Quist-Løkken I, Tewes N, Smith ER, Schwab K, Fischer M, Schwalm MP, Dey R, Aswathaman Sivashanmugam S, Schlesiger S, Moniot S, Knapp S, Hartung IV, Holien T, Loewer A, Hausch F.   +23 more
europepmc   +1 more source

Discovery of PROTACs recruiting the E3 ligase CHIP. [PDF]

RSC Chem Biol
Masuda-Ozawa T, Tomoshige S, Hayakawa E, Sato S, Ohgane K, Ohtake F, Ishikawa M.   +6 more
europepmc   +1 more source

Preclinical evaluation of JQ1 in esophageal squamous cell carcinoma: growth and migration suppression with BRD4-associated DNA damage and apoptotic signaling. [PDF]

Front Pharmacol
Pu C, Liu J, Fan H, Hu H, Chen T, Tang J.   +5 more
europepmc   +1 more source

BRD4 inhibition mitigates acute and chronic corneal injury following topical nitrogen mustard exposure. [PDF]

Mol Ther
Lu Z, Shi S, Xia F, Krishna Chandran AM, Lin J, Iniguez DJ, Motamedi M, Liu H, Zhang W.   +8 more
europepmc   +1 more source

AI-assisted design and virtual profiling of targeted degraders for pancreatic cancer therapy via PROTAC technology. [PDF]

Am J Cancer Res
Du B, Wang K, Wu Z, Qiu S, Konstantinos FD, Yu S.   +5 more
europepmc   +1 more source