Results 121 to 130 of about 19,105 (226)

MiR-218 Inhibits CSE-Induced Apoptosis and Inflammation in BEAS-2B by Targeting BRD4

International Journal of COPD, 2020
Xiaoli Liu,1 Junchen Wang,2,3 Huiling Luo,1 Chengxu Xu,1 Xingyu Chen,1 Rongxuan Zhang1 1Department of Respiratory, The Second People’s Hospital of Lanzhou City, Lanzhou City, Gansu Province, People’s Republic of China; 2Department of ...
Liu X, Wang J, Luo H, Xu C, Chen X, Zhang R   +5 more
doaj  

A BRD4 transzkripciós szerepének elemzése a rexinoid alapú rákkezelésben

Carvedilol (Carv) has been shown to enhance the antiproliferative activity of the rexinoid Bexarotene (Bex). This study focuses on BRD4, an epigenetic reader, to study the mechanisms behind the synergy of Bex+Carv.
Cervantes Ramírez, Sussy Itzeri
core  

Molecular Insight into Function of the Evolutionarily Conserved Brd4 Extraterminal Domain (ET) and Mechanism of Brd4 Functions in Human Diseases

, 2012
Bromodomain protein 4 (Brd4) plays critical roles in development, cancer progression and virus-host pathogenesis. Papillomaviruses (PV) E2 protein associates with Brd4 and this interaction is important for transcriptional regulation of the viral ...
Rahman, Shaila
core  

BRD4 inhibitors broadly promote erastin-induced ferroptosis in different cell lines by targeting ROS and FSP1

Discover Oncology
Ferroptosis, an iron-dependent form of programmed cell death, is a promising strategy for cancer treatment. Bromodomain-containing protein 4 (BRD4) is an epigenetic reader and a promising target for cancer therapeutics.
Chenyang Fan, Xiaohong Guo, Jie Zhang, Wen Zheng, Chonglin Shi, Yongwei Qin, Haoliang Shen, Yang Lu, Yihui Fan, Yanli Li, Liuting Chen, Renfang Mao   +11 more
doaj   +1 more source

BRD4 is focally amplified in ovarian serous adenocarcinoma.

, 2018
(A) BRD4 amplification frequency was surveyed from 559 SNP6.0 Affymetrix copy-number arrays from primary tumors represented in TCGA. (B) IGViewer showing copy-number gain across chromosome 19 in 559 primary high-grade serous ovarian patient samples.
Michael Zinda (2238178), Kelly Jacques (1896415), Maureen M. Hattersley (5545526), Garrett W. Rhyasen (5545529), Wei Zhao (14321), Huawei Chen (320155), Stephen E. Fawell (640947), Jingwen Zhang (608423), Edwin Clark (42221), Gordon B. Mills (120313), Lillian Castriotta (1533460), Yi Yao (365728), Paul D. Lyne (1427734), Austin Dulak (3479099), Farzin Gharahdaghi (1896421)   +14 more
core   +1 more source

Mapping of the MCV LT and Brd4 interaction sites.

, 2012
A. Schematic diagrams of full-length MCV LT protein and truncation mutants used for mapping. All MCV LT fragments were expressed from a pcDNA4C plasmid encoding an Xpress epitope tag. B. Mapping the Brd4 binding site on MCV LT.
Jianxin You (121729), Christopher B. Buck (121726), Jing Li (10611), Rachel M. Schowalter (121719), Xin Wang (91924), Jing Jiao (121723)   +5 more
core   +1 more source

Dihydropteridinone Inhibitors of BRD4 [PDF]

ACS Medicinal Chemistry Letters, 2015
openaire   +2 more sources

Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4

, 2015
SummaryBRD4, a bromodomain and extraterminal domain (BET) family member, is an attractive target in multiple pathological settings, particularly cancer.
Altieri, Martha, Winkler, James D., Raina, Kanak, Hines, John, Coleman, Kevin, Crews, Craig M., Dong, Hanqing, Lu, Jing, Qian, Yimin, Wang, Jing, Crew, Andrew P.   +10 more
core   +1 more source

Recurrent breakpoints in the BRD4 locus reduce toxicity associated with gene amplification

Cell Genomics
Summary: Recent work by the ICGC-PCAWG consortium identified recurrent focal deletions in the BRD4 gene, decreasing expression despite increased copy number.
Jeremiah Wala, Simona Dalin, Sophie Webster, Ofer Shapira, John Busanovich, Shahab Sarmashghi, Rameen Beroukhim, Pratiti Bandopadhayay, Veronica Rendo   +8 more
doaj   +1 more source

Correspondence: Primary Cutaneous NUT Adnexal Carcinoma: A Case Report With Novel Clinical and Pathological Observations

Journal of Cutaneous Pathology, Volume 53, Issue 7, Page 622-623, July 2026.
Woo Cheal Cho
wiley   +1 more source