Results 101 to 110 of about 19,105 (226)

p63 and BRD4: key players in keratinocyte homeostasis

, 2023
In questo studio abbiamo esplorato l'interazione a livello molecolare tra BRD4, noto regolatore epigenetico e co attivatore trascrizionale, e p63, fattore chiave per l’omeostasi cutanea. Utilizzando degli approcci di Gene Onotlogy, saggi di interazione e
FOFFI, ERICA
core   +1 more source

Loss of Brd4 alleviates pathological bone loss via Slc9b2 suppression in osteoclastogenesis

Clinical and Translational Medicine
Background Epigenetic regulation plays a crucial role in skeletal degenerative diseases, including osteoporosis. As an epigenetic reader, bromodomain protein 4 (Brd4) is known as a key driver of gene activation; however, its role in maintaining skeletal ...
Xiaohe Wang, Fangji Luo, Guiqiang Miao, Boyuan Zheng, Chenhao Xu, Vincent Kam Wai Wong, Yuanshu Peng, Rong Zeng, Jinzhu Pang, Xuguang Zhang, Zhenyu Ju, Zhengang Zha, Xiaogang Wang, Xiaofei Zheng, Huan‐Tian Zhang   +14 more
doaj   +1 more source

The Chemical Regulatory Landscape of Biomolecular Condensates

Aggregate, Volume 7, Issue 7, July 2026.
Chemical regulation of biomolecular phase separation offers a unique opportunity to bridge molecular‐level chemistry with emergent cellular organization. Chemically informed strategies for controlling condensate condensates through chemically tractable parameters such as interaction valency, solvent quality, and molecular crowding provides a unifying ...
Di Liu, Xin Zhang
wiley   +1 more source

Quantitative Control of Transposable Elements: From Genome Plasticity to Immune Regulatory Circuits

Cell Biochemistry and Function, Volume 44, Issue 7, July 2026.
ABSTRACT Transposable elements (TEs) constitute nearly half of the human genome and are increasingly recognized as context‐dependent regulators of genome function rather than passive repetitive DNA. This Review synthesizes classical and recent evidence on TE biology, including TE classification, mechanisms of mobilization, host restriction pathways ...
Irving Jesús Reyes‐Barragán
wiley   +1 more source

BRD4-SF interacts with RRP1B.

, 2013
(A) Interaction of epitope-tagged BRD4-SF and RRP1B by reciprocal Co-IP in HEK293 cells using antibodies against the epitope tags, followed by western blot analysis. (B, C) BiFC analysis of BRD4-SF and RRP1B in HeLa cells followed by confocal microscopy.
Farhoud Faraji (135917), Anup Day (487236), Kevin Gardner (487237), Mia Williams (487227), Dominic Esposito (487232), Nicholas Smithers (487233), Kent W. Hunter (135937), Thomas R. Geiger (229776), Rab Prinjha (487235), Nigel P. S. Crawford (404652), Zhen Xiao (111926), Josephine Wu (487228), Keiko Ozato (25065), Dave Lugo (487234), Tyler Merlino (487230), Jude Alsarraj (487225), Allen D. Bosley (487231), Thorkell Andresson (454613), Renard C. Walker (135927), Katherine R. Mattaini (487226), Ngoc-Han Ha (487229)   +20 more
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Table4_AZD5153, a Bivalent BRD4 Inhibitor, Suppresses Hepatocarcinogenesis by Altering BRD4 Chromosomal Landscape and Modulating the Transcriptome of HCC Cells.XLSX

, 2022
BRD4, a chromatin modifier frequently upregulated in a variety of neoplasms including hepatocellular cancer (HCC), promotes cancer cell growth by activating oncogenes through its interaction with acetylated histone tails of nucleosomes.
Robert J. Lee (299150), Xue-Feng Bai (333686), Aaron B. Koenig (12283124), Kalpana Ghoshal (144593), Alexander Pan (12283127), Pearlly Yan (65347), Cho-Hao Lin (12283118), Jimmy Chun-Tien Kuo (12283121), Ding Li (127896)   +8 more
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Circ-OSBPL2 Contributes to Smoke-Related Chronic Obstructive Pulmonary Disease by Targeting miR-193a-5p/BRD4 Axis

International Journal of COPD, 2021
Caifen Zheng,1 Yongping Zhang,2 Yingchun Zhao,3 Yuanfang Duan,1 Qianghua Mu,1 Xinying Wang1 1Department of Respiratory and Critical Care Medicine, The First People’s Hospital of Lianyungang, Lianyungang, People’s Republic of China; 2Blood ...
Zheng C, Zhang Y, Zhao Y, Duan Y, Mu Q, Wang X   +5 more
doaj  

Multiple myeloma: A tale of deregulated transcription factors

HemaSphere, Volume 10, Issue 7, July 2026.
Abstract A comprehensive understanding of the molecular mechanisms underlying multiple myeloma (MM) pathogenesis is essential for developing therapeutic strategies that overcome disease heterogeneity and treatment relapse. In this review, we focus on transcription factors (TFs), key regulators of gene expression that play critical roles in normal ...
Nahia Gómez‐Echarte, Edurne San José‐Enériz, Estíbaliz Urizar‐Compains, Paula Rodriguez‐Otero, Felipe Prósper, Xabier Agirre   +5 more
wiley   +1 more source

Brd4 occupancy and expression in different cells.

, 2014
Cells were either untreated or treated with 1 µM of JQ1 for 2 hours. (A) Chromatin Immunoprecipitation (ChIP) across MYC with anti-C-terminal Brd4 antibody. Each experiment was performed twice, analyzed in triplicate via real-time PCR and reported as the
David H. Price (31011), Ali Shilatifard (513975), Ananda L. Roy (513976), Trent Fowler (513971), Payel Ghatak (232349), Ronald Conaway (513972), Cheng-Ming Chiang (488070), James E. Bradner (513974), Joan Conaway (513973)   +8 more
core   +1 more source

MiR-204-5p Alleviates Neuropathic Pain by Targeting BRD4 in a Rat Chronic Constrictive Injury Model

Journal of Pain Research, 2022
Xiaona Guo,1,* Xia Geng,1,* Yunchao Chu,2 Jianfei Gao,1 Linkai Jiang1 1Pain Department, Dongying People’s Hospital, Dongying, Shandong, People’s Republic of China; 2Pain Department, Shengli Oilfield Central Hospital, Dongying, Shandong, People’s ...
Guo X, Geng X, Chu Y, Gao J, Jiang L
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