Results 101 to 110 of about 20,494 (185)
Cancer Reports, Volume 9, Issue 10, October 2026.ABSTRACT Background Gallbladder cancer (GBC) is a biologically complex malignancy arising from the epithelial lining of the gallbladder, with adenocarcinoma constituting the major histological subtype. Early detection is challenging because of vague clinical manifestations and the organ's deep‐seated anatomical location, resulting in diagnosis at ...
Nisha Manav +4 more
wiley +1 more source
A BRD4 transzkripciós szerepének elemzése a rexinoid alapú rákkezelésben
Carvedilol (Carv) has been shown to enhance the antiproliferative activity of the rexinoid Bexarotene (Bex). This study focuses on BRD4, an epigenetic reader, to study the mechanisms behind the synergy of Bex+Carv.
Cervantes Ramírez, Sussy Itzeri
core
Health Science Reports, Volume 9, Issue 10, October 2026.ABSTRACT Background Exosomes are naturally secreted nanovesicles with high biocompatibility, low immunogenicity, and the ability to traverse biological barriers, making them attractive theragnostic carriers. When engineered to present tumor‐specific antibodies and to deliver antibody‐drug conjugates (ADCs), they may enhance selective targeting of ...
Subham Sarkar +5 more
wiley +1 more source
BET bromodomain inhibitors block binding of BET family bromodomains 1 and 2 (BD1, BD2) to chromatin and have demonstrated clinical activity in NUT carcinoma (NC), a BRD-NUT fusion-driven cancer, but toxicity from BD1 inhibition has limited their ...
Taylor R Durall +18 more
core +1 more source
Journal of Cutaneous Pathology, Volume 53, Issue 10, Page 901-906, October 2026.ABSTRACT Endocrine mucin‐producing sweat gland carcinoma (EMPSGC) is an adnexal neoplasm which typically occurs on periorbital skin and demonstrates overlapping histopathologic features with primary mucinous carcinoma of the skin (MCS). Herein, we report a patient who developed five distinct lesions of EMPSGC and MCS over an eight‐year period, some of ...
Ikuko Hirai +5 more
wiley +1 more source
BRD4 Deficiency Selectively Affects a Unique Developmental Subpopulation in Thymocytes
, 2018 The bromodomain protein BRD4 is a driver in both inflammatory diseases and cancers. It has multiple functions, contributing to chromatin structure and transcription through its intrinsic HAT and kinase activities.
Qing-Rong Chen +8 more
core +1 more source
Discover OncologyFerroptosis, an iron-dependent form of programmed cell death, is a promising strategy for cancer treatment. Bromodomain-containing protein 4 (BRD4) is an epigenetic reader and a promising target for cancer therapeutics.
Chenyang Fan +11 more
doaj +1 more source
BRD4 sustains p63 transcriptional program in keratinocytes
Biology DirectHere, we investigated the potential interaction between bromodomain-containing protein 4 (BRD4), an established epigenetic modulator and transcriptional coactivator, and p63, a member of the p53 transcription factor family, essential for epithelial ...
E. Foffi +6 more
doaj +1 more source
BRD4 is focally amplified in ovarian serous adenocarcinoma.
, 2018 (A) BRD4 amplification frequency was surveyed from 559 SNP6.0 Affymetrix copy-number arrays from primary tumors represented in TCGA. (B) IGViewer showing copy-number gain across chromosome 19 in 559 primary high-grade serous ovarian patient samples.
Michael Zinda (2238178) +14 more
core +1 more source