Results 91 to 100 of about 19,105 (226)
Role of BRD4 in cancer – A review
IP Journal of Diagnostic Pathology and Oncology, 2020 Bromodomain containing protein (BRD4) play a major role in the gene expression, both in normal cell and cancerous cell through direct interaction with acetylated lysine residue at the N- Terminal of histone tail with the help of transcription factors such as RELA, ER, P53.
Kamrudeen Samani +4 more
openaire +2 more sources
Research Progress on Pathogenesis and Treatment of NUT Carcinoma
Chinese Journal of Lung CancerNUT carcinoma (nuclear protein in testis carcinoma) is a rare and highly invasive malignant tumor, which is most common in midline organs and lungs. The characteristic genetic change of NUT carcinoma is the rearrangement of NUT middle carcinoma family ...
Jiaxin DU, Xinwei ZHANG
doaj +1 more source
Plant Biotechnology Journal, EarlyView.ABSTRACT Carnation (Dianthus caryophyllus) contains abundant flavonoid glycosides (FGs), which are important natural functional and colour components. However, there are few reports on the modification of UDP‐glycosyltransferases (UGTs) in relation to flavonoids in carnation.
Xuhong Zhou +6 more
wiley +1 more source
, 2022 BRD4, a chromatin modifier frequently upregulated in a variety of neoplasms including hepatocellular cancer (HCC), promotes cancer cell growth by activating oncogenes through its interaction with acetylated histone tails of nucleosomes.
Robert J. Lee (299150) +8 more
core +1 more source
American Journal of Medical Genetics Part A, Volume 200, Issue 8, Page 1821-1831, August 2026.ABSTRACT There is a strong genetic contribution to the etiology of congenital diaphragmatic hernia (CDH). This study evaluated genetic testing results and diagnostic yield for fetuses and children with CDH. This was a retrospective cohort study of exome sequencing (ES) performed at GeneDx for fetuses and children ≤ 18 years of age with CDH compared ...
Justin Blair +9 more
wiley +1 more source
Human Brd4 interacts with MCV LT.
, 2012 A. MCV LT Co-IP with Brd4. C33A cells were transfected with pcDNA4C-MCV LT. Nuclear extracts IPed with normal rabbit IgG (IgG) or the polyclonal Brd4NA antibody (Brd4) were immunoblotted for MCV LT and Brd4.
Jianxin You (121729) +5 more
core +1 more source
, 2022 BRD4, a chromatin modifier frequently upregulated in a variety of neoplasms including hepatocellular cancer (HCC), promotes cancer cell growth by activating oncogenes through its interaction with acetylated histone tails of nucleosomes.
Robert J. Lee (299150) +8 more
core +1 more source
Signal-Dependent Recruitment of BRD4 to Cardiomyocyte Super-Enhancers Is Suppressed by a MicroRNA
Cell Reports, 2016 BRD4 governs pathological cardiac gene expression by binding acetylated chromatin, resulting in enhanced RNA polymerase II (Pol II) phosphorylation and transcription elongation. Here, we describe a signal-dependent mechanism for the regulation of BRD4 in
Matthew S. Stratton +10 more
doaj +1 more source
ChemBioChem, Volume 27, Issue 13, 14 July 2026.The function of bromodomain‐containing proteins in regulating gene transcription is reviewed here, including the development of chemical probes and targeted protein degradation modalities (e.g., PROTACs). This extends to clinical efforts targeting the BET bromodomain‐containing proteins. Challenges of selectivity, future prospects, and the differential
Cole R. Scholtz, William C. K. Pomerantz
wiley +1 more source
Bromodomain-Containing Protein BRD4 Is Hyperphosphorylated in Mitosis
, 2020 The epigenetic reader BRD4 binds acetylated histones and plays a central role in controlling cellular gene transcription and proliferation. Dysregulation of BRD4′s activity has been implicated in the pathogenesis of a wide variety of cancers. While
Erle S. Robertson +4 more
core +1 more source