Results 91 to 100 of about 20,494 (185)
BRD4 scilencing plus gemcitabine may be a novel therapy for triple-negative breast cancer
Zhongguo aizheng zazhi, 2016 Background and purpose: Breast cancer has the highest morbidity and mortality rate in women worldwide. Triple-negative breast cancer (TNBC) has no specific target and has low survival rate.
陈玉丽, 朱勤伟, 隋晓梅
doaj
Recruitment of BRD4 to the ASXL1 genomic targets depends on the extra-terminal domain of BRD4
Nature CommunicationsASXL1 is a well-established driver of a wide range of cancers. Here, we identify a high level of genetic correlation between ASXL1 and the major transcriptional activator BRD4 in cancer cells and characterize the molecular mechanism underlying this ...
Karthik Selvam +17 more
doaj +1 more source
Computational and Systems Oncology, Volume 6, Issue 1, December 2026.ABSTRACT Inherited factors account for a large share of breast cancer susceptibility, yet the biological consequences of most risk variants are still poorly understood. To address this gap, we studied 175 breast cancer risk variants confirmed by genome‐wide association studies and gathered the genes that lie near them.
Sultana Jannat +11 more
wiley +1 more source
, 2013 (A) Interaction of epitope-tagged BRD4-SF and RRP1B by reciprocal Co-IP in HEK293 cells using antibodies against the epitope tags, followed by western blot analysis. (B, C) BiFC analysis of BRD4-SF and RRP1B in HeLa cells followed by confocal microscopy.
Farhoud Faraji (135917) +20 more
core +1 more source
Current Issues in Molecular BiologyRadiotherapy is an effective treatment for cancer; however, radioresistant cancer cells result in recurrence. Therefore, elucidating the mechanisms of radioresistance is urgently needed.
Nanami Munakata +3 more
doaj +1 more source
International Journal of Cancer, Volume 159, Issue 10, Page 2595-2605, 15 November 2026.ABSTRACT Esophageal adenocarcinoma (EAC) exhibits marked male predominance with male‐to‐female ratios reaching 8.5:1, yet the molecular basis underlying this sex disparity remains poorly characterized. We analyzed 92 EAC specimens using mass spectrometry–based proteomics, comprising 47 female and 45 male tumors from treatment‐naïve patients ...
Alexander Quaas +8 more
wiley +1 more source
Bromodomain-Containing Protein BRD4 Is Hyperphosphorylated in Mitosis
, 2020 The epigenetic reader BRD4 binds acetylated histones and plays a central role in controlling cellular gene transcription and proliferation. Dysregulation of BRD4′s activity has been implicated in the pathogenesis of a wide variety of cancers. While
Erle S. Robertson +4 more
core +1 more source
Targeting BRD4 in the Treatment of Pleural Fibrosis [PDF]
, 2023 Pleural fibrosis (PF) is a respiratory disorder that refers to the thickening and scarring of the pleura. Currently, there is a lack of pharmaceutic treatment options for PF.
Adewumi, Joy
core
CCNE1: A Cell Cycle Regulator That Influences Tumor Progression
Cancer Medicine, Volume 15, Issue 10, October 2026.ABSTRACTCyclin E1 (CCNE1), a pivotal member of the cyclin family, governs the G1/S phase transition of the cell cycle by binding to and activating cyclin‐dependent kinase 2 (CDK2), thereby initiating DNA replication and driving S‐phase entry. In a broad spectrum of human malignancies—including breast, ovarian, gastric, and non‐small cell lung cancers ...
Liang Yan +6 more
wiley +1 more source
Brd4 occupancy and expression in different cells.
, 2014 Cells were either untreated or treated with 1 µM of JQ1 for 2 hours. (A) Chromatin Immunoprecipitation (ChIP) across MYC with anti-C-terminal Brd4 antibody. Each experiment was performed twice, analyzed in triplicate via real-time PCR and reported as the
David H. Price (31011) +8 more
core +1 more source