Results 81 to 90 of about 19,105 (226)
Perturbation of BRD4 Protein Function by BRD4-NUT Protein Abrogates Cellular Differentiation in NUT Midline Carcinoma [PDF]
Journal of Biological Chemistry, 2011 NUT midline carcinoma (NMC) belongs to a class of highly lethal and poorly differentiated epithelial cancers arising mainly in human midline organs. NMC is caused by the chromosome translocation-mediated fusion of the NUT (nuclear protein in testis) gene on chromosome 15 to a few other genes, most frequently the BRD4 gene on chromosome 19.
Junpeng, Yan +4 more
openaire +2 more sources
Domain analysis for nocodazole induced Brd4 release.
, 2012 A. Left: Diagram of Brd4 deletions. BDI and BDII represent bromodomains, ET stands for the ET domain. ΔET and ΔC are devoid of the internal C-terminal region, but contain the extreme C-terminal 83 amino acids.
Minoru Ko (167558) +4 more
core +1 more source
Journal of Orthopaedic Surgery and Research, 2023 Background Human bone marrow mesenchymal stem cells (hBMSCs) are a major source of osteoblast precursor cells and are directly involved in osteoporosis (OP) progression.
Tao Ning +3 more
doaj +1 more source
Journal of Cutaneous Pathology, EarlyView.ABSTRACT Endocrine mucin‐producing sweat gland carcinoma (EMPSGC) is an adnexal neoplasm which typically occurs on periorbital skin and demonstrates overlapping histopathologic features with primary mucinous carcinoma of the skin (MCS). Herein, we report a patient who developed five distinct lesions of EMPSGC and MCS over an eight‐year period, some of ...
Ikuko Hirai +5 more
wiley +1 more source
Cytology‐First Diagnostic Workflow for Melanoma of Unknown Primary With Molecular Profiling
Cytopathology, EarlyView.Cytology‑first diagnostic workflow for melanoma of unknown primary. Fine‑needle aspiration of an enlarged lymph node enables rapid cytologic evaluation and immunocytochemical confirmation of melanocytic lineage (SOX10). This early cytologic diagnosis facilitates timely surgical excision and comprehensive genomic profiling, supporting integrated ...
Hong Yu +3 more
wiley +1 more source
Brd4 is important for MCV DNA replication.
, 2012 A. Brd4 knockdown inhibits MCV replication in vivo. C33A cells were transfected with either a siRNA targeting Brd4 (K.D.) or a non-targeting siRNA control (C.O.). Forty-eight h later, cells were transfected with pT+Ori and this time was set as 0 h. Total
Jianxin You (121729) +5 more
core +1 more source
BRD4 inhibitors attenuate viral attachment.
, 2020 (a and b) Viral attachment was assessed with RT-qPCR analysis in PK15 cells incubated with PRV-QXX (a, MOI = 1) or VSV-GFP (b, MOI = 0.01). (c) Viral attachment was assessed with RT-qPCR analysis in MARC-145 cells incubated with PRRSV-BJ4 (MOI = 10). (d)
Hong-Tao Wu (8616984) +15 more
core +1 more source
The FEBS Journal, EarlyView.TGF‐β signaling regulates extracellular vesicle (EV) release in cancer cells by modulating the expression and activity of genes associated with EV biogenesis. The TGF‐β‐induced upregulation of RAB4A expression facilitates fast endosomal recycling, a process that limits the fusion of multivesicular bodies with the plasma membrane and EV secretion. Hence,
Dorival Mendes Rodrigues‐Junior +5 more
wiley +1 more source
Understanding and addressing resistance to IMiDs immunomodulatory compounds in multiple myeloma
The FEBS Journal, EarlyView.IMiDs are pivotal in the treatment of multiple myeloma. Mechanisms of resistance comprise cell intrinsic and extrinsic pathways, involving tumour microenvironment, immune cell dysfunction, CRBN‐dependent and independent genetic drivers and epigenetic changes.
Maria‐Cynthia Fuentes‐Lacouture +3 more
wiley +1 more source