Results 81 to 90 of about 20,494 (185)
Human Brd4 interacts with MCV LT.
, 2012 A. MCV LT Co-IP with Brd4. C33A cells were transfected with pcDNA4C-MCV LT. Nuclear extracts IPed with normal rabbit IgG (IgG) or the polyclonal Brd4NA antibody (Brd4) were immunoblotted for MCV LT and Brd4.
Jianxin You (121729) +5 more
core +1 more source
BRD4 inhibitors attenuate viral attachment.
, 2020 (a and b) Viral attachment was assessed with RT-qPCR analysis in PK15 cells incubated with PRV-QXX (a, MOI = 1) or VSV-GFP (b, MOI = 0.01). (c) Viral attachment was assessed with RT-qPCR analysis in MARC-145 cells incubated with PRRSV-BJ4 (MOI = 10). (d)
Hong-Tao Wu (8616984) +15 more
core +1 more source
, 2022 BRD4, a chromatin modifier frequently upregulated in a variety of neoplasms including hepatocellular cancer (HCC), promotes cancer cell growth by activating oncogenes through its interaction with acetylated histone tails of nucleosomes.
Robert J. Lee (299150) +8 more
core +1 more source
Chromatin Remodeller BRD9 Orchestrates Odontoblastic Differentiation via Coordinating RUNX2‐KLF4
Cell Proliferation, EarlyView.During odontoblast lineage commitment, the chromatin remodeller BRD9 acts as a critical epigenetic coordinator, orchestrating the chromatin landscape to facilitate synergistic binding of key transcription factors RUNX2 and KLF4 to target loci for odontogenesis.
Wenrui Zeng +8 more
wiley +1 more source
Cytology‐First Diagnostic Workflow for Melanoma of Unknown Primary With Molecular Profiling
Cytopathology, EarlyView.Cytology‑first diagnostic workflow for melanoma of unknown primary. Fine‑needle aspiration of an enlarged lymph node enables rapid cytologic evaluation and immunocytochemical confirmation of melanocytic lineage (SOX10). This early cytologic diagnosis facilitates timely surgical excision and comprehensive genomic profiling, supporting integrated ...
Hong Yu +3 more
wiley +1 more source
A guide to transcriptional cyclin‐dependent kinases in cancer
The FEBS Journal, EarlyView.Transcriptional cyclin‐dependent‐kinases (tCDKs) facilitate gene expression by promoting RNA polymerase II (RNAPII) progression through discrete phases of the transcription cycle. Aberrant tCDK activity is detectable in different human cancers, thereby contributing to de‐regulated gene expression programs that drive oncogenic phenotypes.
Jennifer R. Devlin +2 more
wiley +1 more source
MiR-218 Inhibits CSE-Induced Apoptosis and Inflammation in BEAS-2B by Targeting BRD4
International Journal of COPD, 2020 Xiaoli Liu,1 Junchen Wang,2,3 Huiling Luo,1 Chengxu Xu,1 Xingyu Chen,1 Rongxuan Zhang1 1Department of Respiratory, The Second People’s Hospital of Lanzhou City, Lanzhou City, Gansu Province, People’s Republic of China; 2Department of ...
Liu X +5 more
doaj
Epigenetic control of cellular plasticity in breast cancer progression
The FEBS Journal, EarlyView.Cancer cells undergo cell state transitions, termed plasticity, driving cancer progression and dictating therapeutic response. We define breast cancer plasticity into four interconnected processes: (1) breast cancer stem cell fates, (2) epithelial‐to‐mesenchymal transition, (3) maintenance of luminal identity, and (4) acquisition of therapeutic ...
Ellie J. Massey +2 more
wiley +1 more source
BRD4 and Cancer: going beyond transcriptional regulation
, 2018 BRD4, member of the Bromodomain and Extraterminal (BET) protein family, is largely acknowledged in cancer for its role in super-enhancers (SEs) organization and oncogenes expression regulation.
Benedetta Donati +2 more
core +1 more source
Novel and emerging skin carcinomas and adnexal tumours
Histopathology, EarlyView.The present review aims to provide an overview of the main emerging skin epithelial tumours, with particular emphasis on salivary gland analogue sweat gland tumours and poorly differentiated carcinomas. Epidermal and adnexal tumours of the skin constitute a complex and heterogeneous group of neoplasms, with distinct morphology and behaviour.
Thibault Kervarrec +2 more
wiley +1 more source