Results 61 to 70 of about 20,494 (185)

Research Progress on Pathogenesis and Treatment of NUT Carcinoma

Chinese Journal of Lung Cancer
NUT carcinoma (nuclear protein in testis carcinoma) is a rare and highly invasive malignant tumor, which is most common in midline organs and lungs. The characteristic genetic change of NUT carcinoma is the rearrangement of NUT middle carcinoma family ...
Jiaxin DU, Xinwei ZHANG
doaj   +1 more source

A USP28-BRD4 axis contributes to the acceleration of breast cancer growth by hyperglycemia

Cell Reports
Summary: Diabetes exacerbates breast cancer progression through incompletely understood mechanisms. BRD4, a bromodomain transcriptional coactivator recognizing histone lysine acetylation, is overexpressed in cancer and upregulates tumor-promoting genes ...
Neng Li, Zhi Zhu, Zhenyong Li, Zhonglu Hu, Xiaoshuang Li, Qian Ke, Yumo Chen, Yixiang Huang, Lidong Sun, Tanjing Song   +9 more
doaj   +1 more source

BRD4-NUT histones

BRD4-NUT ...
Zee, Barry
core   +2 more sources

Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy

BMEMat, EarlyView.
Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu, Xuejian Wang, Wenyan Jiang, Wan Hairul Anuar Kamaruddin, Chunyan Fang, Pengfei Zhang   +5 more
wiley   +1 more source

Targeting the BRD4/FOXO3a/CDK6 Axis Sensitizes AKT Inhibition in Luminal Breast Cancer [PDF]

, 2018
BRD4 assembles transcriptional machinery at gene super-enhancer regions and governs the expression of genes that are critical for cancer progression.
Lin, Yiwei, Zhang, Qiang, Shi, Jian, Zeng, Lei, Tai, Fang, He, Yanling, Stewart, Rachel L., Liu, Suling, Deng, Jiong, Duan, Zhibing, Wang, Chi, Zhou, Binhua P., Ghaffari, Saghi, Evers, B. Mark, Guo, Weijie, Chen, Yule, Liu, Jingyi, Lin, Pengnian Charles, Wu, Yadi, Wang, Yifan, Zhou, Ming-Ming   +20 more
core   +1 more source

Circ-OSBPL2 Contributes to Smoke-Related Chronic Obstructive Pulmonary Disease by Targeting miR-193a-5p/BRD4 Axis

International Journal of COPD, 2021
Caifen Zheng,1 Yongping Zhang,2 Yingchun Zhao,3 Yuanfang Duan,1 Qianghua Mu,1 Xinying Wang1 1Department of Respiratory and Critical Care Medicine, The First People’s Hospital of Lianyungang, Lianyungang, People’s Republic of China; 2Blood ...
Zheng C, Zhang Y, Zhao Y, Duan Y, Mu Q, Wang X   +5 more
doaj  

Targeting bromodomain-containing protein 4 (BRD4) inhibits MYC expression in colorectal cancer cells

Neoplasia: An International Journal for Oncology Research, 2019
The transcriptional regulator BRD4 has been shown to be important for the expression of several oncogenes including MYC. Inhibiting of BRD4 has broad antiproliferative activity in different cancer cell types. The small molecule JQ1 blocks the interaction
C. Otto, S. Schmidt, C. Kastner, S. Denk, J. Kettler, N. Müller, C.T. Germer, E. Wolf, P. Gallant, A. Wiegering   +9 more
doaj   +1 more source

Challenges and Pitfalls to Diagnosing NUTM1‐Rearranged Neoplasia of the Pancreas by Cytology and Ancillary Studies

Diagnostic Cytopathology, EarlyView.
ABSTRACT Fine‐needle aspiration cytology specimens are frequently utilized for ancillary studies to identify diagnostic and prognostic information. This case highlights diagnostic pitfalls and challenges in diagnosing NUTM1‐rearranged neoplasia on pancreatic cytology.
Terrance J. Lynn
wiley   +1 more source

MiR-204-5p Alleviates Neuropathic Pain by Targeting BRD4 in a Rat Chronic Constrictive Injury Model

Journal of Pain Research, 2022
Xiaona Guo,1,* Xia Geng,1,* Yunchao Chu,2 Jianfei Gao,1 Linkai Jiang1 1Pain Department, Dongying People’s Hospital, Dongying, Shandong, People’s Republic of China; 2Pain Department, Shengli Oilfield Central Hospital, Dongying, Shandong, People’s ...
Guo X, Geng X, Chu Y, Gao J, Jiang L
doaj  

Noncanonical Nucleotides in the Genome Around the Maternal‐Zygotic Transition

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
In this paper, Kazzazi et al. provide a comprehensive review of the dynamics of nonconventional nucleotides in the genome during early developmental stages, hypothesizing a potential role for these nucleotides in the activation of the zygotic genome. ABSTRACT From the very moment of fertilization and throughout development, the cells of animal embryos ...
Latifa Kazzazy, Dávid Mező, Kinga K. Nagy, Viktória Perey‐Simon, Judit Tóth, Angéla Békési, Beáta Vértessy, Máté Varga   +7 more
wiley   +1 more source