Results 51 to 60 of about 20,494 (185)

Molecular features driving condensate formation and gene expression by the BRD4-NUT fusion oncoprotein are overlapping but distinct

Scientific Reports, 2023
Aberrant formation of biomolecular condensates has been proposed to play a role in several cancers. The oncogenic fusion protein BRD4-NUT forms condensates and drives changes in gene expression in Nut Carcinoma. Here we sought to understand the molecular
Martyna Kosno, Simon L. Currie, Ashwani Kumar, Chao Xing, Michael K. Rosen   +4 more
doaj   +1 more source

Targeted Degradation of Picornaviral 3C Protease via PROTACs Confers High Barrier to Viral Resistance and Broad‐Spectrum Antiviral Activity

Advanced Science, EarlyView.
This study reports D34 as the first PROTAC degrader that targets the 3C protease of picornaviruses. D34 effectively degrades EV71 3C protease via the ubiquitin‐proteasome pathway. More importantly, D34 exhibits a high resistance barrier and shows broad‐spectrum antiviral activity against multiple picornaviruses, highlighting its potential as a novel ...
Weilong Deng, Junyu Chen, Yingyue Pang, Yuanyuan Zhang, Siqian Chen, Guoliang You, Xiaoman Tian, Zhongxin Xu, Jing Wang, Luqing Shang   +9 more
wiley   +1 more source

BRD4 inhibitors block telomere elongation

, 2017
Cancer cells maintain telomere length equilibrium to avoid senescence and apoptosis induced by short telomeres, which are triggered by the DNA damage response. Limiting the potential for telomere maintenance in cancer cells has been long been proposed as
Steven Wang, Alexandra M. Pike, Stella S. Lee, Carla J. Connelly, Carol W. Greider   +4 more
core   +1 more source

Ahcy Acts as an Effector of Hnf4a‐Driven Super‐Enhancer Activation to Alleviate MASLD During Intermittent Fasting

Advanced Science, EarlyView.
Our study identifies an Hnf4a‐driven super‐enhancer of hepatic Ahcy that mediates the protective effects of intermittent fasting against MASLD. Disruption of the Ahcy super‐enhancer reduces Ahcy expression and exacerbates lipid accumulation. This pathway prevents aberrant promoter hypermethylation by maintaining the SAM/SAH balance, as exemplified by ...
Huafeng Chen, Shilin Zhang, Xiaojie Deng, Wenqiang Xie, Fen Xu, Jie Shen, Hua Liang   +6 more
wiley   +1 more source

BRD4 expression against MLH1.

, 2022
The loss of MLH1 expression is associated with low BRD4 H-scores. (TIFF)
Biwei Cao (8487582), Ozlen Saglam (727336), Gokce A. Toruner (7364117), Xuefeng Wang (113961), Jose R. Conejo-Garcia (6055289)   +4 more
core   +1 more source

DNA Damage Induces Dynamic Associations of BRD4/P-TEFb With Chromatin and Modulates Gene Transcription in a BRD4-Dependent and -Independent Manner

Frontiers in Molecular Biosciences, 2020
The bromodomain-containing protein BRD4 has been thought to transmit epigenetic information across cell divisions by binding to both mitotic chromosomes and interphase chromatin. UV-released BRD4 mediates the recruitment of active P-TEFb to the promoter,
Yawei Song, Yawei Song, Yawei Song, Yawei Song, Yawei Song, Gongcheng Hu, Gongcheng Hu, Gongcheng Hu, Gongcheng Hu, Jinping Jia, Mingze Yao, Xiaoshan Wang, Wenliang Lu, Andrew P. Hutchins, Jiekai Chen, Jiekai Chen, Jiekai Chen, Keiko Ozato, Hongjie Yao, Hongjie Yao, Hongjie Yao, Hongjie Yao   +21 more
doaj   +1 more source

A Versatile DNA‐Encoded Library Platform for the Discovery of Highly Cooperative Chemical Inducers of Proximity

Advanced Science, EarlyView.
We present a versatile DNA‐encoded library (DEL) platform designed for rapid library synthesis and subsequent screening for chemical inducers of proximity (CIPs) across various presenter proteins of choice. Applying this approach, we discovered a novel molecular glue‐like compound mediating CRBN‐BRD9 ternary complex formation with remarkable ...
Bingqi Tong, Sunny A. Tang, Yifan Deng, Zhihan Nan, Alison X. Gao, Gregory A. Michaud, Simone Bonazzi, Frédéric Berst, Frédéric J. Zécri, Shuang Liu, William J. Gibson, Stuart L. Schreiber   +11 more
wiley   +1 more source

BRD4 (bromodomain containing 4) [PDF]

, 2007
Review on BRD4 (bromodomain containing 4), with data on DNA, on the protein encoded, and where the gene is ...
Collin, A
core   +1 more source

Domain analysis for nocodazole induced Brd4 release.

, 2012
A. Left: Diagram of Brd4 deletions. BDI and BDII represent bromodomains, ET stands for the ET domain. ΔET and ΔC are devoid of the internal C-terminal region, but contain the extreme C-terminal 83 amino acids.
Minoru Ko (167558), Anup Dey (167541), Akira Nishiyama (167531), Tomohiko Tamura (167550), Keiko Ozato (25065)   +4 more
core   +1 more source

Brd4 modulates diet-induced obesity via PPARγ-dependent Gdf3 expression in adipose tissue macrophages

JCI Insight, 2021
Macrophage-mediated inflammatory response has been implicated in the pathogenesis of obesity and insulin resistance. Brd4 has emerged as a key regulator in the innate immune response.
Xiangming Hu, Xingchen Dong, Guo Li, Yanheng Chen, Jinjing Chen, Xiaoxin He, Hao Sun, Dong-Hyun Kim, Jongsook Kim Kemper, Lin-Feng Chen   +9 more
doaj   +1 more source