Results 41 to 50 of about 19,105 (226)
BRD4: An emerging prospective therapeutic target in glioma [PDF]
Molecular Therapy - Oncolytics, 2021 Despite advances in treatment, the prognosis for glioma patients remains poor. Bromodomain-containing protein 4 (BRD4), a member of the bromodomain and extraterminal (BET) protein family, plays an important role in controlling oncogene expression and genome stability.
Hua Yang +4 more
openaire +3 more sources
Multicomponent Stapling of Glucagon‐Like Peptide‐1 Enables Receptor‐Guided PROTAC Delivery
Angewandte Chemie, EarlyView.We report a stapled glucagon‐like peptide‐1 (GLP‐1) analogue created via multicomponent tryptophan‐mediated Petasis reaction (TMPR). This strategy yields a stabilised peptide with superior helicity and improved potency. Conjugation to a bromodomain‐containing protein 4 (BRD4) degrader creates the first GLP‐1‐guided targeted protein degrader (PROTAC ...
Jan L. Venne +5 more
wiley +2 more sources
Mechanisms of YAP/TAZ transcriptional control
Cell Stress, 2021 Dysregulated gene expression is intrinsic to cell transformation, tumorigenesis and metastasis. Cancer-specific gene-expression profiles stem from gene regulatory networks fueled by genetic and epigenetic defects, and by abnormal signals of the tumor ...
Giusy Battilana +2 more
doaj +1 more source
, 2018 (A) Summary of IOSE proteomics experiment. (B) Gene-ontology analysis of BRD4 short-isoform proteomics hits. (C) Immunoprecipitations were carried out using FLAG (left) or BRD4 (right) antibodies in IOSE cells expressing BRD4 long and short isoforms ...
Michael Zinda (2238178) +14 more
core +1 more source
Mitochondrial fission promotes self-renewal and tumorigenic potential in prostate cancer
Molecular & Cellular Oncology, 2019 The emergence of therapy-resistant cancer stem cells (CSCs) limit the efficacy of prostate cancer treatment. Using genetic knockdown and chemical inhibitors, we demonstrate the critical role of Bromodomain Containing 4 (BRD4) in promoting mitochondrial ...
Gianluca Civenni +2 more
doaj +1 more source
Publisher Correction: BRD4 interacts with NIPBL and BRD4 is mutated in a Cornelia de Lange–like syndrome [PDF]
Nature Genetics, 2018 In the version of this article initially published, Wendy Bickmore and Madapura Pradeepa were incorrectly not indicated as corresponding authors. The error has been corrected in the HTML and PDF versions of the paper.
Gabrielle Olley +14 more
openaire +3 more sources
BRD4 orchestrates genome folding to promote neural crest differentiation [PDF]
, 2021 Higher-order chromatin structure regulates gene expression, and mutations in proteins mediating genome folding underlie developmental disorders known as cohesinopathies.
Koch-Bojalad, Bailey A +21 more
core +1 more source
International Journal of COPD, 2021 Zheng Wang,1 Yuqiang Zuo,2 Zhihong Gao2 1Department of Respiratory Medicine, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050000, People’s Republic of China; 2Department of Physical Examination Center, The Second Hospital ...
Wang Z, Zuo Y, Gao Z
doaj
Scientific Reports, 2023 Aberrant formation of biomolecular condensates has been proposed to play a role in several cancers. The oncogenic fusion protein BRD4-NUT forms condensates and drives changes in gene expression in Nut Carcinoma. Here we sought to understand the molecular
Martyna Kosno +4 more
doaj +1 more source
, 2022 The loss of MLH1 expression is associated with low BRD4 H-scores. (TIFF)
Biwei Cao (8487582) +4 more
core +1 more source