Results 31 to 40 of about 19,105 (226)
Conditional Human BRD4 Knock-In Transgenic Mouse Genotyping and Protein Isoform Detection
Bio-Protocol, 2022 Bromodomain-containing protein 4 (BRD4) is an acetyl-lysine reader protein and transcriptional regulator implicated in chromatin dynamics and cancer development.
Michael Lewis, Shwu- Wu, Cheng- Chiang
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Structural variation of protein-ligand complexes of the first bromodomain of BRD4
, 2021 The bromodomain-containing protein 4 (BRD4), a member of the bromodomain and extra-terminal domain (BET) family, plays a key role in several diseases, especially cancers.
Ellen, Guest +5 more
core +1 more source
Diverse Amine-Acid Coupling Reactions Modulate the Potency of BRD4 PROTACs
, 2023 Protein degradation with proteolysis targeting chimeras (PROTACs) has emerged as a powerful therapeutic strate-gy. PROTACs are heterobifunctional molecules consisting of a target-binding moiety, a linker and an E3 ligase-binding moiety that are commonly ...
Andrew, McGrath +9 more
core +1 more source
PLoS ONE, 2018 BRD4 is a transcriptional co-activator functioning to recruit regulatory complexes to acetylated chromatin. A subset of High-grade Serous Ovarian Cancer (HGSOC) patients are typified by focal, recurrent BRD4 gene amplifications.
Garrett W Rhyasen +14 more
doaj +1 more source
BRD4: a general regulator of transcription elongation
Transcription, 2022 Transcription elongation by RNA polymerase II (Pol II) has emerged as a regulatory hub in gene expression. A key control point occurs during early transcription elongation when Pol II pauses in the promoter-proximal region at the majority of genes in mammalian cells and at a large set of genes in Drosophila. An increasing number of trans-acting factors
Altendorfer, E. +2 more
openaire +3 more sources
ARV-825 Showed Antitumor Activity against BRD4-NUT Fusion Protein by Targeting the BRD4
Journal of Oncology, 2023 Objective. The bromodomain-containing 4 (BRD4) is a member of the bromodomain and extra terminal domain (BET) family, which is an important epigenetic reader. It is currently a promising oncology target. In some tumors, BET bromodomain inhibitors have demonstrated promising results.
Liu Yang, Yue Jing, Xia Xia, Xiushan Yin
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Transcription, 2013 The bromodomain protein BRD4 links cell cycle and transcription, bookmarking active genes during mitosis and serving as a scaffold for transcription factors. Our recent discovery that BRD4 is a RNA Polymerase II CTD kinase identifies a novel transcriptional function. Here we discuss our model in the context of current knowledge.
Ballachanda N, Devaiah, Dinah S, Singer
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Caveolin-2 is regulated by BRD4 and contributes to cell growth in pancreatic cancer
Cancer Cell International, 2020 Background The bromodomain and extra-terminal domain (BET) family of proteins, especially BRD4 play an important role in epigenetic regulation, and are essential for cell survival and also are promising anticancer targets.
Feng Jiao +6 more
doaj +1 more source
STAR Protocols, 2022 Molecular cloning of BRD4-L is a challenging technique, because the DNA insert is formed by a long, GC-rich sequence, which folds into secondary structures. The present protocol defines a specific strategy to amplify BRD4-L, followed by the successful cloning of the gene into an overexpression vector.
Ana Luiza Drumond-Bock +4 more
openaire +3 more sources
Frontiers in Medicine, 2020 Objectives: This study aimed to explore the relationship between bromodomain-containing protein 4 (BRD4), epithelial–mesenchymal transition (EMT), and disease severity in chronic rhinosinusitis with nasal polyps (CRSwNP).Methods: We performed ...
Xuanchen Zhou +10 more
doaj +1 more source