Results 11 to 20 of about 19,105 (226)
BRD4 inhibitors block telomere elongation [PDF]
Nucleic Acids Research, 2017 Cancer cells maintain telomere length equilibrium to avoid senescence and apoptosis induced by short telomeres, which trigger the DNA damage response. Limiting the potential for telomere maintenance in cancer cells has been long been proposed as a therapeutic target.
Steven Wang +5 more
openaire +3 more sources
Transcriptome analysis of dominant-negative Brd4 mutants identifies Brd4-specific target genes of small molecule inhibitor JQ1 [PDF]
Scientific Reports, 2017 The bromodomain protein Brd4 is an epigenetic reader and plays a critical role in the development and maintenance of leukemia. Brd4 binds to acetylated histone tails and activates transcription by recruiting the positive elongation factor P-TEFb.
Tim-Michael Decker +6 more
doaj +2 more sources
BRD4 interacts with NIPBL and BRD4 is mutated in a Cornelia de Lange–like syndrome [PDF]
Nature Genetics, 2018 We found that the clinical phenotype associated with BRD4 haploinsufficiency overlapped with that of Cornelia de Lange syndrome (CdLS), which is most often caused by mutation of NIPBL. More typical CdLS was observed with a de novo BRD4 missense variant, which retained the ability to coimmunoprecipitate with NIPBL, but bound poorly to acetylated ...
Olley, Gabrielle +15 more
openaire +7 more sources
BRD4: an effective target for organ fibrosis
Biomarker ResearchAbstractFibrosis is an excessive wound-healing response induced by repeated or chronic external stimuli to tissues, significantly impacting quality of life and primarily contributing to organ failure. Organ fibrosis is reported to cause 45% of all-cause mortality worldwide. Despite extensive efforts to develop new antifibrotic drugs, drug discovery has
Qun Wei +8 more
openaire +4 more sources
médecine/sciences, 2018 La physiologie d’une cellule est dictée par l’intégration des signaux qu’elle reçoit et la mise en place de réponses adaptées par le biais, entre autres, de programmes transcriptionnels adéquats. Pour assurer un contrôle optimal de ces réponses, des mécanismes de régulation ont été sélectionnés, dont un processus de pause transcriptionnelle et de levée
Alessandro Furlan +9 more
core +5 more sources
BRD4 (bromodomain containing 4) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on BRD4 (bromodomain containing 4), with data on DNA, on the protein encoded, and where the gene is implicated.
Collin, A
openaire +2 more sources
BRD4-mediated repression of p53 is a target for combination therapy in AML [PDF]
, 2021 Acute myeloid leukemia (AML) is a typically lethal molecularly heterogeneous disease, with few broad-spectrum therapeutic targets. Unusually, most AML retain wild-type TP53, encoding the pro-apoptotic tumor suppressor p53.
McGarry, Lynn +46 more
core +2 more sources
Molecular Cancer, 2021 High-grade serous ovarian carcinoma (HGSOC) is the most aggressive type of ovarian cancer, often diagnosed at advanced stages. Molecularly, HGSOC shows high degree of genomic instability associated with large number of genetic alterations.
Ana Luiza Drumond-Bock +1 more
doaj +1 more source
Brd4 is on the move during inflammation [PDF]
Trends in Cell Biology, 2014 Enhancer landscapes are shaped by the integrated functions of lineage-specific and signal-dependent transcription factors. A new study by Brown et al. suggests that the signal-dependent transcription factor NF-kB can modulate global enhancer activities by altering the occupancy of Brd4, a BET bromodomain coactivator protein, across the genome.
Yali, Xu, Christopher R, Vakoc
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BRD4 promotes heterotopic ossification through upregulation of LncRNA MANCR
Bone & Joint Research, 2021 Aims: Acquired heterotopic ossification (HO) is a debilitating disease characterized by abnormal extraskeletal bone formation within soft-tissues after injury. The exact pathogenesis of HO remains unknown.
Lei Liu +9 more
doaj +1 more source