Results 21 to 30 of about 20,494 (185)
Super-enhancers and the super-enhancer reader BRD4: tumorigenic factors and therapeutic targets
Cell Death Discovery, 2023 Transcriptional super-enhancers and the BET bromodomain protein BRD4 are emerging as critical drivers of tumorigenesis and therapeutic targets. Characterized by substantial accumulation of histone H3 lysine 27 acetylation (H3K27ac) signals at the loci of
Haihong Qian +5 more
doaj +1 more source
Disease-associated Brd4 mutation – linking chromatin binding and the DNA damage response [PDF]
, 2019 Acetylation of lysine residues is a histone modification associated with active chromatin. The modified residues provide docking sites for the epigenetic reader BRD4, which binds to the acetylated lysines via its two bromodomains.
Olley, Gabrielle Jade
core +1 more source
Conditional Human BRD4 Knock-In Transgenic Mouse Genotyping and Protein Isoform Detection
Bio-Protocol, 2022 Bromodomain-containing protein 4 (BRD4) is an acetyl-lysine reader protein and transcriptional regulator implicated in chromatin dynamics and cancer development.
Michael Lewis, Shwu- Wu, Cheng- Chiang
doaj +1 more source
Discovery of an Unexpected Similarity in Ligand Binding Between BRD4 and PPARγ [PDF]
, 2019 Knowledge about interrelationships between different proteins is crucial in fundamental research for the elucidation of protein networks and pathways.
Jette, Pretzel +3 more
core +2 more sources
Covalent-Fragment Screening of Brd4 Identifies a Ligandable Site Orthogonal to the Acetyl-Lysine Binding Sites [PDF]
, 2019 Brd4, a member of the bromodomain and extraterminal domain (BET) family, has emerged as a promising epigenetic target in cancer and inflammatory disorders.
Ziyang, Xu +5 more
core +2 more sources
PLoS ONE, 2018 BRD4 is a transcriptional co-activator functioning to recruit regulatory complexes to acetylated chromatin. A subset of High-grade Serous Ovarian Cancer (HGSOC) patients are typified by focal, recurrent BRD4 gene amplifications.
Garrett W Rhyasen +14 more
doaj +1 more source
Mechanisms of YAP/TAZ transcriptional control
Cell Stress, 2021 Dysregulated gene expression is intrinsic to cell transformation, tumorigenesis and metastasis. Cancer-specific gene-expression profiles stem from gene regulatory networks fueled by genetic and epigenetic defects, and by abnormal signals of the tumor ...
Giusy Battilana +2 more
doaj +1 more source
Caveolin-2 is regulated by BRD4 and contributes to cell growth in pancreatic cancer
Cancer Cell International, 2020 Background The bromodomain and extra-terminal domain (BET) family of proteins, especially BRD4 play an important role in epigenetic regulation, and are essential for cell survival and also are promising anticancer targets.
Feng Jiao +6 more
doaj +1 more source
Mitochondrial fission promotes self-renewal and tumorigenic potential in prostate cancer
Molecular & Cellular Oncology, 2019 The emergence of therapy-resistant cancer stem cells (CSCs) limit the efficacy of prostate cancer treatment. Using genetic knockdown and chemical inhibitors, we demonstrate the critical role of Bromodomain Containing 4 (BRD4) in promoting mitochondrial ...
Gianluca Civenni +2 more
doaj +1 more source
Cancer Biology & Therapy, 2022 Acute myeloid leukemia (AML) is a highly cancerous and aggressive hematologic disease with elevated levels of drug resistance and relapse resulting in high mortality.
Li Ma +21 more
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