Results 111 to 120 of about 20,494 (185)

Recurrent breakpoints in the BRD4 locus reduce toxicity associated with gene amplification

Cell Genomics
Summary: Recent work by the ICGC-PCAWG consortium identified recurrent focal deletions in the BRD4 gene, decreasing expression despite increased copy number.
Jeremiah Wala, Simona Dalin, Sophie Webster, Ofer Shapira, John Busanovich, Shahab Sarmashghi, Rameen Beroukhim, Pratiti Bandopadhayay, Veronica Rendo   +8 more
doaj   +1 more source

Bromodomain protein BRD4 directs mitotic cell division of mouse fibroblasts by inhibiting DNA damage

iScience
Summary: Bromodomain protein BRD4 binds to acetylated histones to regulate transcription. BRD4 also drives cancer cell proliferation. However, the role of BRD4 in normal cell growth has remained unclear. Here, we investigated this question by using mouse
Tiyun Wu, Haitong Hou, Anup Dey, Mahesh Bachu, Xiongfong Chen, Jan Wisniewski, Fuki Kudoh, Chao Chen, Sakshi Chauhan, Hua Xiao, Richard Pan, Keiko Ozato   +11 more
doaj   +1 more source

BRD4: an effective target for organ fibrosis

Fibrosis is an excessive wound-healing response induced by repeated or chronic external stimuli to tissues, significantly impacting quality of life and primarily contributing to organ failure.
Hongyao Liu, Conghui Deng, Tinghong Ye, Taixiong Xue, Qun Wei, Cailing Gan, Yuting Xie, Chunheng Mo, Meng Sun   +8 more
core   +1 more source

Inhibition of BRD4 activates the AKT-SIRT3 signaling pathway to suppress apoptosis and attenuate hyperoxia-induced lung injury

Frontiers in Bioengineering and Biotechnology
As a critical pulmonary complication in oxygen therapy, hyperoxia-induced lung injury (HILI) is featured with edema, alveolar wall thickening, and inflammatory cell infiltration. Bromodomain containing 4 (BRD4) has been documented as a vital regulator of
Kangjie Qin, Jie Zheng, Yuting Zhang, Yiyu Wang, Han Qin, Qiuyu Dai, Xinxin Liu, Liting Cheng, Kun Yu, Miao Chen, Song Qin   +10 more
doaj   +1 more source

Multiple roles of Brd4 in the human papillomavirus life cycle [PDF]

, 2014
While human papillomavirus (HPV) vaccines protect against acquiring new infections, there is currently no antiviral treatment for eradicating persistent HPV infections.
Helfer, Christine M, Helfer, Christine M.   +1 more
core  

Bromodomain-Containing 4 Is a Positive Regulator of Interleukin-34 Production in the Gut

Cells
Experimental evidence suggests that, in the inflamed gut of inflammatory bowel disease (IBD) patients, interleukin-34 (IL-34) triggers detrimental signaling pathways.
Eleonora Franzè, Federica Laudisi, Rachele Frascatani, Lorenzo Tomassini, Elena De Cristofaro, Carmine Stolfi, Giovanni Monteleone   +6 more
doaj   +1 more source

Mapping of the MCV LT and Brd4 interaction sites.

, 2012
A. Schematic diagrams of full-length MCV LT protein and truncation mutants used for mapping. All MCV LT fragments were expressed from a pcDNA4C plasmid encoding an Xpress epitope tag. B. Mapping the Brd4 binding site on MCV LT.
Jianxin You (121729), Christopher B. Buck (121726), Jing Li (10611), Rachel M. Schowalter (121719), Xin Wang (91924), Jing Jiao (121723)   +5 more
core   +1 more source

Targeting BRD4 ameliorates experimental emphysema by disrupting super-enhancer in polarized alveolar macrophage

Respiratory Research
Background Chronic obstructive pulmonary disease (COPD) is a progressive chronic lung disease characterized by chronic airway inflammation and emphysema.
Difei Li, Xing Shi, Yuqiong Yang, Yao Deng, Dandan Chen, Shuyu Chen, Jinyong Wang, Guanxi Wen, Zhenyu Liang, Fengyan Wang, Jiaqi Gao, Yuanyuan Liu, Danna Wang, Ruifang Liang, Haizhao Xu, Rongchang Chen, Shanze Chen, Lingwei Wang   +17 more
doaj   +1 more source

BRD4 inhibition leads to MDSC apoptosis and enhances checkpoint blockade therapy

The Journal of Clinical Investigation
BRD4 is an epigenetic reader protein that regulates oncogenes such as myc in cancer. However, its additional role in shaping immune responses via regulation of inflammatory and myeloid cell responses is not yet fully understood.
Himanshu Savardekar, Andrew Stiff, Alvin Liu, Robert Wesolowski, Emily Schwarz, Ian C. Garbarine, Megan C. Duggan, Sara Zelinskas, Jianying Li, Gabriella Lapurga, Alexander Abreo, Lohith Savardekar, Ryan Parker, Julia Sabella, Mallory J. DiVincenzo, Brooke Benner, Steven H. Sun, Dionisia Quiroga, Luke Scarberry, Gang Xin, Anup Dey, Keiko Ozato, Lianbo Yu, Merve Hasanov, Debasish Sundi, Richard C. Wu, Kari L. Kendra, William E. Carson III   +27 more
doaj   +1 more source

Cbx4 SUMOylates BRD4 to regulate the expression of inflammatory cytokines in post-traumatic osteoarthritis

Experimental and Molecular Medicine
Brominated domain protein 4 (BRD4) is a chromatin reader known to exacerbate the inflammatory response in post-traumatic osteoarthritis (PTOA) by controlling the expression of inflammatory cytokines. However, the extent to which this regulatory effect is
Ding Zhou, Jia-Ming Tian, Zi Li, Jun Huang   +3 more
doaj   +1 more source