Results 131 to 140 of about 19,105 (226)

Bromodomain protein BRD4 directs mitotic cell division of mouse fibroblasts by inhibiting DNA damage

iScience
Summary: Bromodomain protein BRD4 binds to acetylated histones to regulate transcription. BRD4 also drives cancer cell proliferation. However, the role of BRD4 in normal cell growth has remained unclear. Here, we investigated this question by using mouse
Tiyun Wu, Haitong Hou, Anup Dey, Mahesh Bachu, Xiongfong Chen, Jan Wisniewski, Fuki Kudoh, Chao Chen, Sakshi Chauhan, Hua Xiao, Richard Pan, Keiko Ozato   +11 more
doaj   +1 more source

A Genetic Screen for Genes That Impact Peroxisomes in Drosophila Identifies Candidate Genes for Human Disease

G3: Genes, Genomes, Genetics, 2020
Hillary K. Graves, Sharayu Jangam, Kai Li Tan, Antonella Pignata, Elaine S. Seto, Shinya Yamamoto, Michael F. Wangler   +6 more
doaj   +1 more source

BRD4 sustains p63 transcriptional program in keratinocytes

Biology Direct
Here, we investigated the potential interaction between bromodomain-containing protein 4 (BRD4), an established epigenetic modulator and transcriptional coactivator, and p63, a member of the p53 transcription factor family, essential for epithelial ...
E. Foffi, A. Violante, R. Pecorari, A. M. Lena, F. Rugolo, G. Melino, E. Candi   +6 more
doaj   +1 more source

Inhibition of BRD4 activates the AKT-SIRT3 signaling pathway to suppress apoptosis and attenuate hyperoxia-induced lung injury

Frontiers in Bioengineering and Biotechnology
As a critical pulmonary complication in oxygen therapy, hyperoxia-induced lung injury (HILI) is featured with edema, alveolar wall thickening, and inflammatory cell infiltration. Bromodomain containing 4 (BRD4) has been documented as a vital regulator of
Kangjie Qin, Jie Zheng, Yuting Zhang, Yiyu Wang, Han Qin, Qiuyu Dai, Xinxin Liu, Liting Cheng, Kun Yu, Miao Chen, Song Qin   +10 more
doaj   +1 more source

Model of BRD4 regulation of herpes simplex virus replication.

, 2016
BRD4 participates in epigenetics regulation by recognition of acetyl lysine residues with its bromodomains (BD1, BD2). BRD4 also regulates the transcription of cellular and viral genes by recruitment of the positive transcription elongation factor (P ...
Ke Ren (34504), Yayi Hou (139450), Erguang Li (367297), Xiaoqing Chen (89898), Wei Zhang (405), Yue Dai (287672), Ren Xiang Tan (1633183), Yingyu Ma (3229974), Yimei Fan (615439)   +8 more
core   +1 more source

Targeting BRD4 ameliorates experimental emphysema by disrupting super-enhancer in polarized alveolar macrophage

Respiratory Research
Background Chronic obstructive pulmonary disease (COPD) is a progressive chronic lung disease characterized by chronic airway inflammation and emphysema.
Difei Li, Xing Shi, Yuqiong Yang, Yao Deng, Dandan Chen, Shuyu Chen, Jinyong Wang, Guanxi Wen, Zhenyu Liang, Fengyan Wang, Jiaqi Gao, Yuanyuan Liu, Danna Wang, Ruifang Liang, Haizhao Xu, Rongchang Chen, Shanze Chen, Lingwei Wang   +17 more
doaj   +1 more source

Bromodomain-Containing 4 Is a Positive Regulator of Interleukin-34 Production in the Gut

Cells
Experimental evidence suggests that, in the inflamed gut of inflammatory bowel disease (IBD) patients, interleukin-34 (IL-34) triggers detrimental signaling pathways.
Eleonora Franzè, Federica Laudisi, Rachele Frascatani, Lorenzo Tomassini, Elena De Cristofaro, Carmine Stolfi, Giovanni Monteleone   +6 more
doaj   +1 more source

The potential of BRD4 inhibition in tumour mechanosignaling

Journal of Cellular and Molecular Medicine, 2023
Antonios N. Gargalionis, Kostas A. Papavassiliou, Athanasios G. Papavassiliou   +2 more
openaire   +3 more sources

Functional interdependence of BRD4 and DOT1L in MLL leukemia.

, 2016
Targeted therapies against disruptor of telomeric silencing 1-like (DOT1L) and bromodomain-containing protein 4 (BRD4) are currently being evaluated in clinical trials.
Isabelle Becher, Marnie E Blewitt, Enid Y N Lam, Sarah Ftouni, Aoife Ward, Ricky W Johnstone, Tony Kouzarides, Kym Stanley, Rab K Prinjha, David Smil, Sarah-Jane Dawson, Gerard Joberty, Cheryl H Arrowsmith, Christopher Carpenter, Paola Grandi, Peter Brown, Gerard Drewes, Brian J P Huntly, Margherita Ghisi, Meike Wiese, Yih-Chih Chan, Chun Yew Fong, Neil Garton, Ester Cannizzaro, Dean Tyler, Mark A Dawson, Dave Lugo, Laura MacPherson, Andrew J Bannister, Chen-Fang Weng, Omer Gilan   +30 more
core   +1 more source

Targeting BRD4 in the Treatment of Pleural Fibrosis

, 2023
Pleural fibrosis (PF) is a respiratory disorder that refers to the thickening and scarring of the pleura. Currently, there is a lack of pharmaceutic treatment options for PF.
Adewumi, Joy
core