Results 151 to 160 of about 19,105 (226)

Sinusoidal endothelial cells control liver inflammation and fibrosis. [PDF]

J Clin Invest
Chen Y, He Y.
europepmc   +1 more source

Discovery of a KLHL41 Ligand for Muscle Specific Protein Degradation. [PDF]

Nat Commun
Yim J, Lee J, Kim S, Choi J, Yoon S, Cho H, Jung S, Yoo G, Lee S, Park H, Lee J, Park J.   +11 more
europepmc   +1 more source

NHWD-870, a Potent BET Inhibitor, Ameliorated Endotoxemia-Induced Hepatic Inflammation via Suppression of BRD4-STAT1 Signaling and Macrophage M1 Polarization. [PDF]

J Inflamm Res
Zhou N, Tan B, Jiang Y, Wang H, Peng W, Yin M, Fu L, Peng S.   +7 more
europepmc   +1 more source

Computational Discovery of Dual-Target LDHA/BRD4 Inhibitors Targeting the Lactate-Kla-B7-H3 Immunosuppressive Axis Through AI-Driven Virtual Screening. [PDF]

Pharmaceuticals (Basel)
Zhao R, Han M, Zhang B, Ma M, Zhou X, Sun J.   +5 more
europepmc   +1 more source

BRD4 directs myofiber identity and metabolic adaptation through CHD4 cooperation. [PDF]

Nat Commun
Zhou Z, Liu L, Xu Z, Zhou D, Liu A, Yuan J, Shen G, Guo Q, Yin Y, Mao Y, Sun W, Xiao L, Lv C, Kiram A, Yang L, Jia Y, Ke L, Fang L, Li W, Fu T, Gan Z.   +20 more
europepmc   +1 more source

A new 4-atom linker enables PROTAC development and imaging. [PDF]

RSC Chem Biol
Letsios S, Carrasco G, Lee M, Wagiet M, Madureira M, Samways M, Khan Z, Brunton VG, Grubisha O, Hulme AN.   +9 more
europepmc   +1 more source

BRD4 Inhibition alleviates sepsis-associated acute kidney injury via suppression of NOX4-mediated oxidative stress and inflammation. [PDF]

Cell Death Discov
Jia J, Ji K, Zhou Y, Huang Y, Li A, Ye F, Huang W, Chen F, Lu G.   +8 more
europepmc   +1 more source

Polyphosphate as a novel regulator of super-enhancer complexes: disruption of phase separation and gene expression. [PDF]

Nucleic Acids Res
Yang Z, Jia Z.
europepmc   +1 more source

Correction of the molecular phenotype of X-linked Dystonia-Parkinsonism reveals a non-canonical function of BRD4. [PDF]

Nat Commun
Capponi S, Ehret S, Camgöz Z, Gather F, Vaine CA, Özyerli-Göknar E, Follo M, Bragg DC, Vogel T, Timmers HTM.   +9 more
europepmc   +1 more source

Loop Plasticity Drives Paralog-Specific Recognition in BET ET Domains. [PDF]

J Chem Inf Model
Alvarez G, Sebastian E, Mondal A, Roth MJ, Montelione GT, Perez A.   +5 more
europepmc   +1 more source