Inducing DNA damage through R-loops to kill cancer cells
Molecular & Cellular Oncology, 2021 R-loops are intermediate structures of transcription that can accumulate when transcriptional elongation is blocked by inhibiting BRD4. In normal cells, R-loop persistence suppresses firing of adjacent replication origins.
Fred C. Lam +2 more
doaj +1 more source
Conditional Human BRD4 Knock-In Transgenic Mouse Genotyping and Protein Isoform Detection
Bio-Protocol, 2022 Bromodomain-containing protein 4 (BRD4) is an acetyl-lysine reader protein and transcriptional regulator implicated in chromatin dynamics and cancer development.
Michael Lewis, Shwu- Wu, Cheng- Chiang
doaj +1 more source
BET bromodomain protein inhibition is a therapeutic option for medulloblastoma [PDF]
, 2013 Medulloblastoma is the most common malignant brain tumor of childhood, and represents a significant clinical challenge in pediatric oncology, since overall survival currently remains under 70%.
Althof, Kristina +13 more
core +4 more sources
LARP7 suppresses P-TEFb activity to inhibit breast cancer progression and metastasis. [PDF]
, 2014 Transcriptional elongation by RNA polymerase (Pol) II is essential for gene expression during cell growth and differentiation. The positive transcription elongation factor b (P-TEFb) stimulates transcriptional elongation by phosphorylating Pol II and ...
Ji, Xiaodan +3 more
core +3 more sources
The Bromodomain Protein 4 Contributes to the Regulation of Alternative Splicing
Cell Reports, 2019 Summary: The bromodomain protein 4 (BRD4) is an atypical kinase and histone acetyl transferase (HAT) that binds to acetylated histones and contributes to chromatin remodeling and early transcriptional elongation.
Sheetal Uppal +8 more
doaj +1 more source
Supercharging BRD4 with NUT in carcinoma
Oncogene, 2021 NUT carcinoma (NC) is an extremely aggressive squamous cancer with no effective therapy. NC is driven, most commonly, by the BRD4-NUT fusion oncoprotein. BRD4-NUT combines the chromatin-binding bromo- and extraterminal domain-containing (BET) protein, BRD4, with an unstructured, poorly understood protein, NUT, which recruits and activates the histone ...
Kyle P. Eagen, Christopher A. French
openaire +3 more sources
Interrogating Histone Acetylation and BRD4 as Mitotic Bookmarks of Transcription
Cell Reports, 2019 Summary: Global changes in chromatin organization and the cessation of transcription during mitosis are thought to challenge the resumption of appropriate transcription patterns after mitosis.
Vivek Behera +13 more
doaj +1 more source
PLoS ONE, 2018 BRD4 is a transcriptional co-activator functioning to recruit regulatory complexes to acetylated chromatin. A subset of High-grade Serous Ovarian Cancer (HGSOC) patients are typified by focal, recurrent BRD4 gene amplifications.
Garrett W Rhyasen +14 more
doaj +1 more source
Inhibition of bromodomain and extra-terminal (BET) proteins increases NKG2D ligand MICA expression and sensitivity to NK cell-mediated cytotoxicity in multiple myeloma cells. role of cMYC-IRF4-miR-125b interplay [PDF]
, 2016 Background: Anticancer immune responses may contribute to the control of tumors after conventional chemotherapy and different observations have indicated that chemotherapeutic agents can induce immune responses resulting in cancer cell death and immune ...
Abruzzese, MARIA PIA +13 more
core +13 more sources
BRD4-BRD2 isoform switching coordinates pluripotent exit and Smad2-dependent lineage specification [PDF]
, 2017 Pluripotent Stem Cells (PSCs) hold great clinical potential, as they possess the capacity to differentiate into fully specialised tissues such as pancreas, liver, neurons and cardiac muscle.
Ciulli, Alessio +8 more
core +5 more sources