Results 51 to 60 of about 26,367 (213)

Brd4 is on the move during inflammation [PDF]

Trends in Cell Biology, 2014
Enhancer landscapes are shaped by the integrated functions of lineage-specific and signal-dependent transcription factors. A new study by Brown et al. suggests that the signal-dependent transcription factor NF-kB can modulate global enhancer activities by altering the occupancy of Brd4, a BET bromodomain coactivator protein, across the genome.
Yali, Xu, Christopher R, Vakoc
openaire   +2 more sources

BRD4 isoforms have distinct roles in tumour progression and metastasis in rhabdomyosarcoma

EMBO Reports
BRD4, a bromodomain and extraterminal (BET) protein, is deregulated in multiple cancers and has emerged as a promising drug target. However, the function of the two main BRD4 isoforms (BRD4-L and BRD4-S) has not been analysed in parallel in most cancers.
Dipanwita Das, Jia Yu Leung, Shivaranjani Balamurugan, Vinay Tergaonkar, Amos Hong Pheng Loh, Cheng-Ming Chiang, Reshma Taneja   +6 more
doaj   +1 more source

Targeting GLI factors to inhibit the Hedgehog pathway [PDF]

, 2015
Hedgehog (Hh) signaling has emerged in recent years as an attractive target for anticancer therapy because its aberrant activation is implicated in several cancers. Major progress has been made in the development of SMOOTHENED (SMO) antagonists, although
Alfonsi, Romina, Botta, Bruno, DI MARCOTULLIO, Lucia, Infante, Paola, Mori, Mattia   +4 more
core   +2 more sources

BRD4 jump-starts transcription after mitotic silencing [PDF]

Genome Biology, 2011
The chromatin adapter BRD4 may be crucial for transmitting epigenetic information by acting as a histone acetylation-dependent gene bookmark and accelerating post-mitotic transcriptional reactivation.
Voigt, Philipp, Reinberg, Danny
openaire   +2 more sources

Chronic Hypoxia Disrupts Spermatogenesis Through ASXL2–EZH2–Mediated Microtubule Destabilization

Advanced Science, EarlyView.
This study reveals the mechanism by which chronic hypoxia impairs spermatogenesis via the ASXL2–EZH2 axis, hindering the transition of spermatids from round to elongated forms. Key findings reveal that under hypoxic conditions, downregulated ASXL2 expression reduces EZH2 binding to the CEP162 promoter, leading to decreased H3K27me3 modification and ...
Jun Yin, Mengjie Zhang, Wenying Liu, Wenlong Shen, Debao Li, Hongming Miao, Fang Deng, Gang Zhang, Yi Tian, Yi Zhang, Zhihu Zhao, Bing Ni   +11 more
wiley   +1 more source

LncRNA UCA1 Accelerates the Progression of Ulcerative Colitis via Mediating the miR-331-3p/BRD4 Axis

International Journal of General Medicine, 2021
Jun Rao, Lihua Shao, Min Lin, Jin Huang, Li Fan Department of Gastroenterology, The Affiliated Changzhou No.2 People’s Hospital of Nanjing Medical University, Changzhou, People’s Republic of ChinaCorrespondence: Li FanDepartment of ...
Rao J, Shao L, Lin M, Huang J, Fan L
doaj  

Selective Antagonists of the Bronchiolar Epithelial NF-κB-Bromodomain-Containing Protein 4 Pathway in Viral-Induced Airway Inflammation

Cell Reports, 2018
Summary: The mechanisms by which the mammalian airway detects invading viral pathogens to trigger protective innate neutrophilic inflammation are incompletely understood.
Bing Tian, Zhiqing Liu, Jun Yang, Hong Sun, Yingxin Zhao, Maki Wakamiya, Haiying Chen, Erik Rytting, Jia Zhou, Allan R. Brasier   +9 more
doaj   +1 more source

BRD4 PROTAC degrader MZ1 exerts anticancer effects in acute myeloid leukemia by targeting c-Myc and ANP32B genes

Cancer Biology & Therapy, 2022
Acute myeloid leukemia (AML) is a highly cancerous and aggressive hematologic disease with elevated levels of drug resistance and relapse resulting in high mortality.
Li Ma, Jianwei Wang, Yongping Zhang, Fang Fang, Jing Ling, Xinran Chu, Zimu Zhang, Yanfang Tao, Xiaolu Li, Yuanyuan Tian, Zhiheng Li, Xu Sang, Kunlong Zhang, Lihui Lu, Xiaomei Wan, Yanling Chen, Juanjuan Yu, Ran Zhuo, Shuiyan Wu, Jun Lu, Jian Pan, Shaoyan Hu   +21 more
doaj   +1 more source

Coactivator condensation at super-enhancers links phase separation and gene control [PDF]

, 2019
Super-enhancers (SEs) are clusters of enhancers that cooperatively assemble a high density of the transcriptional apparatus to drive robust expression of genes with prominent roles in cell identity.
Abraham, Brian J., Boija, Ann, Chakraborty, Arup K, Cisse, Ibrahim I, Coffey, Eliot Leo, Dall’Agnese, Alessandra, Day, Daniel S., Guo, Yang E., Hannett, Nancy M., Hnisz, Denes, Klein, Isaac A., Lee, Tong Ihn, Li, Charles Han, Manteiga, John Colonnese, Sabari, Benjamin R., Schuijers, Jurian, Sharp, Phillip A., Shrinivas, Krishna, Vasile, Eliza, Young, Richard A., Zamudio Montes de Oca, Alicia   +20 more
core   +1 more source

Discovery of SKP2‐Recruiting PROTACs for Target Protein Degradation

Advanced Science, EarlyView.
Based on the SKP2‐targeting ligand SL1, we designed non‐covalent PROTACs by linking it with the BRD4 inhibitor JQ1 and the AR antagonist AL through a linker. These PROTACs successfully induced the ubiquitination of BRD4 and AR, followed by proteasome‐mediated degradation.
Guanjun Dong, Aima Huang, Ziqing Zhao, Bikai Lai, Xin Pan, Huiyu Yang, Xiaohan Xu, Tianwei Wang, Fangchen Zhao, Zhimin Zhang, Yongbo Xue, Guanjun Deng, Wenbin Deng, Jianwei Chen   +13 more
wiley   +1 more source