Results 61 to 70 of about 1,949,697 (379)

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

open access: yesFEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer   +10 more
wiley   +1 more source

Simulation Analysis of Breakdown Characteristics in Isolation Switch Fracture in Same Frequency and Phase AC Withstand Voltage Test of 110 kV Three-Phase Cylindrical GIS

open access: yesZhongguo dianli, 2021
The same frequency and phase AC withstand voltage test technology has been widely used in the insulation performance test of inspection or expansion in 220kV Gas Insulated Switchgear (GIS), which can avoid stopping running grid bus of the system. However,
Yifan QIN   +6 more
doaj   +1 more source

Effect of impact ionization in scaled pHEMTs [PDF]

open access: yes, 2000
The effect of impact ionization on pseudomorphic high electron mobility transistors is studied using Monte Carlo simulations when these devices are scaled into deep decanano dimensions.
Asenov, A.   +3 more
core  

Streamer evolution arrest governed amplified AC breakdown strength of graphene and CNT colloids

open access: yes, 2018
The present article experimentally explores the concept of large improving the AC dielectric breakdown strength of insulating mineral oils by the addition of trace amounts of graphene or CNTs to form stable dispersions.
Chattopadhyay, Ankur   +3 more
core   +1 more source

Effect of impact ionization in the InGaAs absorber on excess noise of avalanche photodiodes [PDF]

open access: yes, 2005
The effects of impact ionization in the InGaAs absorption layer on the multiplication, excess noise and breakdown voltage are modeled for avalanche photodiodes (APDs), both with InP and with InAlAs multiplication regions.
David, J.P.R.   +3 more
core   +2 more sources

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

open access: yesFEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura   +8 more
wiley   +1 more source

DC Breakdown Voltage of Synthetic Ester Liquid-Based Nanofluids

open access: yesIEEE Access, 2020
Synthetic esters are potential substitutes for mineral oil in power transformers owing to their biodegradability and excellent dielectric withstand. Furthermore, the addition of certain nanoparticles improves the cooling property of liquids.
Abderrahmane Beroual   +2 more
doaj   +1 more source

Lightning impulse tests on air-breakdown level in point-plane electrode configuration [PDF]

open access: yes, 2014
In the past several decades, extensive amount of research work has been done to understand the fundamental characteristics of the electrical breakdown.
Che Mok @ Adnan, Mohd Dasri
core  

Reducing AC impedance measurement errors caused by the DC voltage dependence of broadband high-voltage bias-tees [PDF]

open access: yes, 2007
During the AC impedance characterization of devices, from the kHz-range up to the GHz-range, accuracy can be lost when a DC voltage is applied. Commercial high-voltage broadband bias-tees are often voltage-dependent, which can cause inaccuracies at low ...
Reimann, K.   +2 more
core   +2 more sources

RAD50 missense variants differentially affect the DNA damage response and mitotic progression

open access: yesFEBS Letters, EarlyView.
RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker   +9 more
wiley   +1 more source

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