Results 61 to 70 of about 65,483 (305)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Numerical simulation study of rock breaking mechanism by high voltage electric pulse

矿业科学学报, 2023
High-voltage electric pulse(HVEP)drilling has become a new and efficient rock breaking method, which is also the research focus in the field of drilling speed increase.
Liu Weiji, Zhang Youjian, Zhu Xiaohua, Feng Wenrong   +3 more
doaj   +1 more source

TIME-DEPENDENT DIELECTRIC BREAKDOWN CHARACTERIZATION OF A HIGH VOLTAGE CAPACITOR [PDF]

, 2011
NXP Semiconductors Business Unit (BU) Automotive is a corporate organization that provides design technology for the automotive product creation process.
Sasongko, Brecia Nurastu
core  

Anomalous plasma temperature at supercritical phase of pressurized CO2 after pulsed breakdown followed by large short-circuit current [PDF]

, 2018
The relation between breakdown characteristics and plasma temperature of a pulsed arc discharge in highly pressurized CO2 was investigated up to a supercritical phase.
Kamagahara, Takeshi, Matsuda, Yoshinobu, Sasaki, Mitsuru, Yamashita, Takahiko, Ashizuka, Naokazu, Kiyan, Tsuyoshi, Furusato, Tomohiro, Inada, Yuki   +7 more
core   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

The Investigation of Field Plate Design in 500 V High Voltage NLDMOS

Advances in Condensed Matter Physics, 2015
This paper presents a 500 V high voltage NLDMOS with breakdown voltage (VBD) improved by field plate technology. Effect of metal field plate (MFP) and polysilicon field plate (PFP) on breakdown voltage improvement of high voltage NLDMOS is studied.
Donghua Liu, Xiangming Xu, Feng Jin, Wenting Duan, Huihui Wang, Jing Shi, Yuan Yao, Jun Hu, Wensheng Qian, Pengfei Wang, David Wei Zhang   +10 more
doaj   +1 more source

>10 kV GaN-on-GaN PN power diode with double field plate structure [PDF]

APL Electronic Devices
GaN-based power devices have great potential for medium-to-high voltage applications. In this work, we present the device design of a vertical GaN-on-GaN PN power diode using a double field plate structure and guard-rings for electrical field management ...
Yibo Xu, Vijay Gopal Thirupakuzi Vangipuram, Tadao Hashimoto, Edward Letts, Daryl Key, Hongping Zhao, Wu Lu   +6 more
doaj   +1 more source

Modeling of the Partial Discharge Process in a Liquid Dielectric: Effect of Applied Voltage, Gap Distance, and Electrode Type

, 2013
The partial discharge (PD) process in liquid dielectrics is influenced by several factors. Although the PD current contains the information representing the discharge process during the PD event, it is difficult to determine the detailed dynamics of what
Qing Yang, Tao Yuan, Yang, Q, Chilong Jiang, Sima, W, Jiang, C, Yuan, T, Lewin, P L, Paul Lewin, Wenxia Sima   +9 more
core   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Study of Parameters Affecting Breakdown Voltage of Bipolar Static Induction Transistor

Известия высших учебных заведений России: Радиоэлектроника, 2017
The article considers structural and technological parameters affecting breakdown voltage of a BSIT transistor cell. The main objective of the scientific research in that field is optimization of manufacturing techniques of power electronics transistor ...
T. A. Ismailov, A. R. Shakhmaeva, B. A. Shangereeva   +2 more
doaj