Results 81 to 90 of about 944,465 (289)

Management of Febrile Neutropenia - a German Prospective Hospital Cost Analysis in Lymphoproliferative Disorders, Non-Small Cell Lung Cancer, and Primary Breast Cancer [PDF]

, 2011
Background: Febrile neutropenia/leukopenia (FN/FL) is the most frequent dose-limiting toxicity of myelosuppressive chemotherapy, but German data on economic consequences are limited.
Angela Ihbe-Heffinger, Bernadette J. Paessens, Bodey GP, Christian Peschel, Christoph von Schilling, Herold M, Ihbe-Heffinger A, Karin Berger, Klastersky J, Lalami Y, Margarita Shlaen, Marion Kiechle, Mayordomo JI, Nina Gottschalk, Paessens BJ, Rudolf Bernard, Timmer-Bonte JN, Tjan-Heijnen VC, Volker R. Jacobs, Weycker D   +19 more
core   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Costs associated with febrile neutropenia in solid tumor and lymphoma patients - an observational study in Singapore. [PDF]

, 2014
BackgroundThe primary objective was to describe the total direct inpatient costs among solid tumor and lymphoma patients with chemotherapy-induced febrile neutropenia (FN) and the factors that were associated with higher direct cost.
A Bosly, A Chan, A Ihbe-Heffinger, AG Freifeld, Alexandre Chan, B Dulisse, C O’Brien, CL Bennett, GH Lyman, GH Lyman, GH Lyman, H Khalili, J Klastersky, JI Mayordomo, Li Yang Hsu, LM Poon, M Wong, Mabel Wong, MB Schilling, NM Kuderer, SL Michels, SY Liou, V Caggiano, Xiao Jun Wang, YP Zhou   +24 more
core   +2 more sources

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Benign Breast Disease among Patients Visiting the Breast and Endocrine Clinic of a Tertiary Care Centre

Journal of Nepal Medical Association
Introduction: Breast diseases encompass a wide range of conditions, including benign and malignant disorders. Given the significant burden of breast-related health issues in the community, there is a critical need to understand the prevalence.
Sishir Poudel, Sushan Pokharel, Sarada Khadka   +2 more
doaj   +1 more source

Giant Lipoma of the Breast

Archives of Plastic Surgery, 2013
Lipomas are benign mesenchymal tumors that develop in areas of abundant adipose tissue. Due to the fatty composition of the breast, difficulties in diagnosis, treatment, and reconstruction are often encountered.
Luis Ramírez-Montaño, Erik Vargas-Tellez, Walid L Dajer-Fadel, Silvia Espinosa Maceda   +3 more
doaj   +1 more source

LncRNA SNHG7 Mediates the Chemoresistance and Stemness of Breast Cancer by Sponging miR-34a

Frontiers in Oncology, 2020
Chemoresistance is considered to be a major cause of the recurrence and metastasis of breast cancer (BC). LncRNA SNHG7 has been reported to be upregulated in breast cancer and to promote tumor progression and metastasis.
Zhi-hua Li, Zhi-hua Li, Ni-si Yu, Qing Deng, Qing Deng, Yulu Zhang, Yang-yang Hu, Gang Liu, Gang Liu, Kedi Huang, Kedi Huang   +10 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Biomarkers of aging associated with past treatments in breast cancer survivors. [PDF]

, 2017
Radiation and chemotherapy are effective treatments for cancer, but are also toxic to healthy cells. Little is known about whether prior exposure to these treatments is related to markers of cellular aging years later in breast cancer survivors.
Bower, Julienne E, Breen, Elizabeth C, Carroll, Judith E, Chapman, Aaron M, Esquivel, Stephanie, Ganz, Patricia A, Hogan, Matt, Irwin, Michael R, Petersen, Laura, Ramos-Perlberg, Sam, Schiestl, Robert, Scuric, Zorica   +11 more
core   +2 more sources

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source