Results 161 to 170 of about 2,528,262 (264)

Nanoparticle‐Mediated TIPE1 mRNA Delivery Enhances Paclitaxel Sensitivity in Triple‐Negative Breast Cancer by Modulating RAB7A Ubiquitination‐Associated Stability and Autophagy

Advanced Science, EarlyView.
TIPE1m NPs nanoparticles restore TIPE1 expression, promote RAB7A ubiquitination and degradation, suppress autophagic flux, and resensitize paclitaxel‐resistant triple‐negative breast cancer to therapy. ABSTRACT Acquired paclitaxel (PTX) resistance remains a major obstacle in triple‐negative breast cancer (TNBC) treatment.
Wei Hu, Qishuai Chen, Yan Ma, Yang Liu, Xianing Dong, Wenjuan Wei, Jianxin Du, Shusheng Qiu, Maojin Tian, Peiqing Zhao   +9 more
wiley   +1 more source

"No Man's Land": Addressing the Upper Inner Quadrant in Oncoplastic Breast Surgery: A Review of Contemporary Techniques. [PDF]

Plast Reconstr Surg Glob Open
Hashmi AP, Khan FH.
europepmc   +1 more source

Targeting Hippocampal PTEN Suppresses Ferroptosis and Rescues Cognitive Decline in Alzheimer's Disease via Dual AKT/GSK3β/Nrf2 and AKT/STAT3 Axes

Advanced Science, EarlyView.
PTEN knockdown activates AKT phosphorylation, promoting Nrf2 nuclear translocation and STAT3 activation, which upregulates GPX4 and antioxidant enzymes HO‐1, SOD1, SOD2, and NQO1. These coordinated changes reduce lipid peroxidation and ROS, inhibit ferroptosis, and ultimately ameliorate cognitive impairment in APP/PS1 transgenic mice, highlighting a ...
Da‐Wei Wang, Meng‐Meng Liu, Yu‐Chen Zhao, Jia‐Yi Li, Wen Li, Xin Yu   +5 more
wiley   +1 more source

Development and Validation of Machine Learning Models in Predicting Prognosis of Breast Cancer Patients with Lymph Nodes Metastasis Following Neoadjuvant Chemotherapy

Breast Cancer: Targets and Therapy
Yanjia Fan,1,* Yudi Jin,2,* Cheng Tian,1 Yu Zhang,1 Chi Zhang,1 Haochen Yu,1 Shengchun Liu1 1Department of Breast and Thyroid Surgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China ...
Fan Y, Jin Y, Tian C, Zhang Y, Zhang C, Yu H, Liu S   +6 more
doaj  

A review of radiological characteristics and patterns of fat necrosis after different autologous breast surgery techniques. [PDF]

Insights Imaging
Smeins NNPM, Kuijlaars ZMA, Pérez Rodrigo S, Heuts EM, Piatkowski A, van Nijnatten TJA.   +5 more
europepmc   +1 more source

A Rare De Novo Missense Mutation in IFT122 Confers a Genetic Susceptibility Factor of Idiopathic Pediatric Uveitis Via Trio‐based Whole‐Exome Sequencing

Advanced Science, EarlyView.
A rare de novo IFT122‐A773E variant is identified in idiopathic pediatric uveitis and shown to exacerbate retinal inflammation and barrier dysfunction. Mechanistically, the variant enhances IFT43 interaction, elevates calcium signaling, and activates the MEK/ERK/FRA1 axis, revealing a previously unrecognized cilia‐associated pathway that may increase ...
Qian Zhou, Jiaxing Huang, Yilin Wang, Xingran Li, Xianyang Liu, Lingyu Dai, Hongshun Li, Qingfeng Wang, Jiangyi Liu, Guannan Su, Wanyun Zhang, Yang Deng, Qingfeng Cao, Yujie Lai, Xiang Luo, Changwei Huang, Ling Chen, Shengping Hou, Peizeng Yang   +18 more
wiley   +1 more source

Joint Association of Heavy Metals Exposure With Mortality Among Cancer Survivors

International Journal of Clinical Practice
Boqian Yu, Shiyuan Zhang, Hao Yu, Rongjie Ye, Danping Wu, Xiaotian Yang, Kun Qiao, Chunlei Tan, Shuqiang Liu, Quan Yuan, Yuanxi Huang   +10 more
doaj   +1 more source

Radiation-Induced Angiosarcoma Following Breast Surgery: A Case Report. [PDF]

Surg Case Rep
Hayashi M, Kobayashi Y, Semba R, Ogura K, Murakami F, Kimura K.   +5 more
europepmc   +1 more source

Transcription Factor HOXC11 Drives Colorectal Cancer Progression and Metastasis via CAMK2A‐Dependent CXCL5 Upregulation

Advanced Science, EarlyView.
HOXC11 drives colorectal cancer progression by transcriptionally activating CAMK2A, which triggers NF‐κB–dependent CXCL5 upregulation. CXCL5–CXCR2 signaling further reinforces HOXC11 expression through the ERK1/2–SP1 axis, forming a prometastatic positive feedback loop that is effectively disrupted by combined CAMK2A and CXCR2 inhibition.
Qingyang Sun, Hengjie Xu, Sheng Yang, Jiahui Zhou, Chuanxin Tian, Hongxu Nie, Chi Jin, Tuo Wang, Zhihao Chen, Junwei Tang, Yifei Feng, Xiaowei Wang, Yueming Sun   +12 more
wiley   +1 more source

The Impact of Socioeconomic Factors and Racial Disparities on Complications in Breast Conservation Surgery: A Single-Institution Retrospective Cohort Study

The Breast Journal
Liane N. Obaid, Janice S. Zhang, Grace Y. Lee, Fardeen Bhimani, Susan L. Jao, Carolyn Rachofsky, Lesley G. Coe, Arianna Cavalli, Michelle Ki, Juan Lin, Anjuli Gupta, Sheldon Feldman, Maureen McEvoy   +12 more
doaj   +1 more source