Results 81 to 90 of about 22,199 (300)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Timing as a sexually selected trait: the right mate at the right moment [PDF]

, 2017
Sexual selection favours the expression of traits in one sex that attract members of the opposite sex for mating. The nature of sexually selected traits such as vocalization, colour and ornamentation, their fitness benefits as well as their costs have ...
Buck, C. Loren, Casagrande, Stefania, Dominoni, Davide, Greives, Timothy, Hau, Michaela, Hazlerigg, David, Hut, Roelof A., Wagner, Gabriela   +7 more
core   +3 more sources

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

The effects of extended photoperiod and warmth on hair growth in ponies and horses at different times of year.

PLoS ONE, 2020
Photoperiod is considered the most dominant environmental cue allowing animals to anticipate and adapt to seasonal changes. In seasonally breeding mammals, changes in daylength alter pineal melatonin secretion and pituitary prolactin secretion.
Christiane O'Brien, Megan Ruth Darcy-Dunne, Barbara Anne Murphy   +2 more
doaj   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Accident-tolerant hybrid ceramics for fusion breeding blanket

Materials & Design
In a water-cooled ceramic breeding blanket for fusion reactors, hydrogen gas generation by steam oxidation of metallic Be compounds (i.e. neutron multiplier) in a loss-of-coolant accident (LOCA) raises major safety concerns. Li–Be hybrid ceramics has a potential to reduce hydrogen generation significantly, however, the stable compositions and ...
Keisuke Mukai, Taehyun Hwang, Minoru Kusaba, Jae-Hwan Kim   +3 more
openaire   +2 more sources

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Progress report no. 3 [PDF]

, 1972
Statement of responsibility on title-page reads: editors: M.J. Driscoll, D.D. Lanning, I. Kaplan; contributors: S. T. Brewer, G.J. Brown, P. Delaquil, M.J. Driscoll, G.A. Ducat, I.A. Forbes, M. V. Gregory, S.Y. Ho, M.S. Kalra, C.S. Kang, L.T.
Brewer, Shelby Templeton, Brown, Gilbert Jay, De Laquil, Pascal, Driscoll, Michael J., Ducat, Glenn Alexander, Forbes, Ian Alexander, Gregory, Michael Vladimir, Ho, Simon Yeung-Nam, Kalra, Manjeet Singh, Kang, Chʻang-sun, Kaplan, Irving, 1912-, Kim, L. T. Massachusetts Institute of Technology, Lanning, David D., Lazewatsky, Joel L., Mason, Edward A. (Edward Archibald), 1924-, Ortiz, Nestor Ruben, Rasmussen, Norman C., Rickard, I. C. Massachusetts Institute of Technology, Roberson, K. D. Massachusetts Institute of Technology, Supple, A. T. Massachusetts Institute of Technology, Thompson, Alan Martin, Tzanos, C. P.   +21 more
core  

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Progress report no. 5 [PDF]

, 1974
Includes bibliographical referencesProgress report; June 30, 1974U.S.
Brown, Gilbert Jay, Chan, Joseph Kwok-Kwong, Choong, Philip Tsi-shien, Driscoll, Michael J., Kadiroğlu, Osman Kemal, Kalra, Manjeet Singh, Leveckis, Algis Stephen, Lukic, Yovan D., Masterson, Robert Edward, Miethe, V. A. (Virginia A.), Scheinert, Paul Albert, Shin, Jae In, Supple, A. T. Massachusetts Institute of Technology, Tagishi, Akinori, Yeung, Man-kit   +14 more
core