Comparative Quantitative Proteomic Analysis of High and Low Toxin-Producing Karenia brevis Strains Reveals Differences in Polyketide Synthase Abundance and Redox Status of the Proteome [PDF]
Marine DrugsTo identify differentially abundant polyketide synthases (PKSs) and to characterize the biochemical consequences of brevetoxin biosynthesis, bottom-up, TMT-based quantitative proteomics and redox proteomics were conducted to compare two strains of the ...
Kathleen S. Rein +5 more
doaj +2 more sources
Brevetoxin Metabolites: Emerging Toxins in French Shellfish Determined by LC-MS/MS and ELISA [PDF]
Marine DrugsIn France, as part of the monitoring program for the emergence of marine toxins in shellfish (EMERGTOX), brevetoxins (BTX-2, BTX-3) were first detected in shellfish from Corsica (Mediterranean Sea) in 2018.
Zouher Amzil +4 more
doaj +2 more sources
Immune Modulating Brevetoxins: Monocyte Cytotoxicity, Apoptosis, and Activation of M1/M2 Response Elements Is Dependent on Reactive Groups [PDF]
Marine Drugs, 2022 Brevetoxins are a suite of marine neurotoxins that activate voltage-gated sodium channels (VGSCs) in cell membranes, with toxicity occurring from persistent activation of the channel at high doses.
Jennifer R. McCall +4 more
doaj +2 more sources
Brevetoxin versus Brevenal Modulation of Human Nav1 Channels [PDF]
Marine Drugs, 2023 Brevetoxins (PbTx) and brevenal are marine ladder-frame polyethers. PbTx binds to and activates voltage-gated sodium (Nav) channels in native tissues, whereas brevenal antagonizes these actions.
Rocio K. Finol-Urdaneta +3 more
doaj +2 more sources
Brevetoxin Dynamics and Bioavailability from Floc Following PAC-Modified Clay Treatment of Karenia brevis Blooms [PDF]
ToxinsHarmful algal blooms (HABs) caused by the dinoflagellate Karenia brevis present serious ecological and public health concerns due to the production of brevetoxins (BTX).
Nicholas R. Ohnikian +8 more
doaj +2 more sources
Detection of Brevetoxin in Human Plasma by ELISA. [PDF]
J Anal Toxicol, 2022 Abstract Florida red tides have become more common and persistent in and around the Gulf of Mexico. When in bloom, red tides can produce brevetoxins in high concentrations, leading to human exposures primarily through contaminated food and ocean spray.
Cunningham BR +4 more
europepmc +4 more sources
Emerging Insights into Brevetoxicosis in Sea Turtles [PDF]
AnimalsThis review summarizes the current understanding of how brevetoxins, produced by Karenia brevis during harmful algal blooms, impact sea turtle health.
Remco A. Nederlof +5 more
doaj +2 more sources
Chemiluminescent Receptor Binding Assay for Ciguatoxins and Brevetoxins Using Acridinium Brevetoxin-B2 [PDF]
Toxins, 2019 Ciguatera is the term for poisoning resulting from eating fish from tropical or subtropical regions. The causative toxins collectively named ciguatoxins (CTXs) widely differ in structures depending on their geographic origins, which range from the ...
Kazuya Murata, Takeshi Yasumoto
doaj +3 more sources
Marine Drugs, 2012 Hemocytes mediate a series of immune reactions essential for bivalve survival in the environment, however, the impact of harmful algal species and their associated phycotoxins upon bivalve immune system is under debate.
Dafré A L +2 more
exaly +3 more sources
Brevetoxin Aptamer Selection and Biolayer Interferometry Biosensor Application [PDF]
ToxinsBrevetoxins (PbTxs) are very potent marine neurotoxins that can cause an illness clinically described as neurologic shellfish poisoning (NSP). These toxins are cyclic polyether in chemistry and have increased their geographical distribution in the past 2
Bo Hu +8 more
doaj +2 more sources