Results 21 to 30 of about 1,095 (165)
Brevetoxin derivatives that inhibit toxin activity [PDF]
Chemistry and Biology, 2000 The brevetoxins are marine neurotoxins that interfere with the normal functions of the voltage-gated Na(+) channel. We have identified two brevetoxin derivatives that do not exhibit pharmacological properties typical of the brevetoxins and that function as brevetoxin antagonists.PbTx-3 and benzoyl-PbTx-3 elicited Na(+) channel openings during steady ...
Kathleen Rein +2 more
exaly +3 more sources
Marine Drugs, 2020 Emerging literature suggests that after a stroke, the peri-infarct region exhibits dynamic changes in excitability. In rodent stroke models, treatments that enhance excitability in the peri-infarct cerebral cortex promote motor recovery. This increase in
Thomas F Murray +2 more
exaly +3 more sources
Brevetoxin PbTx2 Modulates Oxidative Stress and Inflammatory Response in an In Vitro Human Immune Cell Line [PDF]
ToxicsBrevetoxins (PbTx) exert detrimental effects on marine organisms and humans, mainly through alterations in immune cell function. This study evaluated the immunotoxic potential of sublethal concentrations of PbTx-2 using the THP-1 human monocyte cell line
Ambbar Aballay-González +6 more
doaj +2 more sources
Toxins, 2018 Brevetoxin-1 (BTX-1), a marine toxin mostly produced by the dinoflagellatae Karenia brevis, has caused the death of marine organisms and has had numerous toxicological effects on human health.
Shihua Wang, Shiwei Xiao, Sumei Ling
exaly +3 more sources
“Algal-dromes”: a novel conceptual approach to illness in humans exposed to harmful algal bloom toxins [PDF]
Frontiers in ToxicologyAlthough adverse health effects from harmful algal bloom (HAB) toxins have been described since antiquity, the true worldwide incidence and disease burden has yet to be defined.
Brett Johnson +4 more
doaj +2 more sources
Design of a Duplex-to-Complex Structure-Switching Approach for the Homogeneous Determination of Marine Biotoxins in Water [PDF]
ToxinsIn this report, we describe a fluorescent assay for the detection of six marine toxins in water. The mechanism of detection is based on a duplex-to-complex structure-switching approach.
Awatef Al-Tabban +5 more
doaj +2 more sources
The Cardioprotective Potential of Marine Venom and Toxins [PDF]
ToxinsCardiovascular disease (CVD) continues to be the primary cause of morbidity and mortality worldwide, underscoring the urgent need for novel therapeutic alternatives.
Virginia Heaven Mariboto Siagian +1 more
doaj +2 more sources
HABs Karenia brevis and Pseudo-nitzschia pre- and post-Hurricane Michael [PDF]
Journal of Water and Health, 2023 Increased occurrences of harmful algal blooms (HAB) in the Gulf of Mexico, and even worldwide, yield concern for increases in brevetoxin exposure leading to respiratory illness or even death, highlighting the need for extensive scientific research and ...
Josh Alarcon +8 more
doaj +2 more sources
Marine Drugs, 2008 Harmful algal blooms (HABs) of the toxic dinoflagellate, Karenia brevis, produce red tide toxins, or brevetoxins. Significant health effects associated with red tide toxin exposure have been reported in sea life and in humans, with brevetoxins documented
Catherine Walsh +2 more
exaly +2 more sources
Predicting <i>Karenia brevis</i> Induced Respiratory Irritation at Individual Southwest Florida Beaches Using Cell Abundances Plus Wind Direction and Speed. [PDF]
GeohealthAbstract Nearly annually, blooms of the dinoflagellate Karenia brevis form along the southwest Florida coast leading to a variety of negative impacts, including respiratory irritation (RI) in humans. To limit these impacts, NOAA's National Centers for Coastal Ocean Science (NCCOS) developed a RI model to provide beach‐goers with a category‐based ...
Collins KM +6 more
europepmc +2 more sources