Results 171 to 180 of about 2,771 (230)
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The Marine Neurotoxin Brevetoxin (PbTx-2) Inhibits Karenia brevis and Mammalian Thioredoxin Reductases by Targeting Different Residues.

Journal of Natural Products, 2021
The brevetoxins, neurotoxins produced by Karenia brevis, the Florida red tide dinoflagellate, effect fish and wildlife mortalities and adverse public health and economic impacts during recurrent blooms.
Ricardo Colon   +5 more
semanticscholar   +1 more source

Neurotoxic: Ciguatoxin and brevetoxin—From excitotoxicity to neurotherapeutics

Marine Neurotoxins, 2021
Brevetoxins and ciguatoxins are lipid-soluble polyether marine natural products that produce, respectively, neurotoxic shellfish poisoning and Ciguatera in humans.
T. F. Murray
semanticscholar   +1 more source

Cardiovascular effects of brevetoxins in dogs

Toxicon, 1985
In anesthetized spontaneously breathing dogs, brevetoxin caused dose-dependent periods of apnea and, at high doses, respiratory arrest. In artificially ventilated dogs, i.v. brevetoxin caused complex dose-related cardiovascular changes consisting of: (1) bradycardia; (2) triphasic blood pressure changes, sequentially characterized by depressor/pressor ...
G L, Johnson, J J, Spikes, S, Ellis
openaire   +2 more sources

Total Synthesis of Brevetoxin B

Journal of the American Chemical Society, 2005
The convergent total synthesis of brevetoxin B (1) has been achieved. The intramolecular allylation of the O,S-acetal 20, prepared from the alpha-chlorosulfide 17 and the alcohol 5, was carried out using AgOTf as a Lewis acid to give the diene 21, predominantly.
Isao, Kadota   +3 more
openaire   +2 more sources

The investigation of early metabolic level perturbation of northern quahog (Mercenaria mercenaria) in response to brevetoxin.

Molecular Omics
Brevetoxins are a type of neurotoxin produced in red tide blooms. Northern quahogs (M. mercenaria) are extensively used in commercial aquaculture farming, and early-stage metabolomics studies can provide early warnings of brevetoxins for farmers. In this
Bo Wang   +4 more
semanticscholar   +1 more source

Systematic design of hydrophobic deep eutectic solvents by VEGA, COSMO-RS, and experiments for efficient removal of Saxitoxin and brevetoxin from water.

Chemosphere
Harmful algal blooms (HABs) and their associated neurotoxins, Brevetoxin (PbTx3) and Saxitoxin (STX), pose significant environmental, economic, and public health challenges.
L. F. Guidugli   +2 more
semanticscholar   +1 more source

Absolute configuration of brevetoxins

Journal of the Chemical Society, Chemical Communications, 1986
The absolute configuration of the dinoflagellate toxins, brevetoxins, has been unequivocally determined by X-ray crystallography of a chiral dioxolane derivative.
Yuzuru Shimizu   +4 more
openaire   +1 more source

The effects of bupivacaine and brevetoxin on RAW 264.7 macrophage inflammatory responses are not modulated by plasma membrane voltage-gated sodium ion channels 2231

Journal of Immunology
Macrophages are leukocytes that are an integral part of the innate immune system. Recently, we have shown that the red tide toxin, brevetoxin, and the local anesthetic, bupivacaine, modulate the release of inflammatory cytokines from RAW 264.7 ...
Brandon Rodriguez, M. Mujtaba
semanticscholar   +1 more source

Evaluation of brevetoxin’s modulation of inflammatory responses in RAW 264.7 murine macrophage cells 2214

Journal of Immunology
Brevetoxins are marine algal biotoxins present in warm coastal regions during red tide blooms and bind to and modulate voltage-gated sodium ion channel (VGSC) function on neuronal cells to confer their deleterious activity.
M. Mujtaba, Brandon Rodriguez
semanticscholar   +1 more source

The chemistry of brevetoxins: A review

Toxicon, 1985
The structure of the unique 'red tide' dinoflagellate neurotoxin, brevetoxin-B is presented and the experimental data supporting the chemical structure is discussed. A brief account of the other brevetoxins and their structural relationships is also presented.
openaire   +2 more sources

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