Results 181 to 190 of about 2,771 (230)

The structure of brevetoxin C

Tetrahedron Letters, 1982
Abstract The structure of brevetoxin C (BTX-C), a polyether marine toxin from Ptychodiscus brevis , has been elucidated by comparison of its spectral data with those of brevetoxin B (BTX-B).
Jerzy Golik, John C. James, Koji Nakanishi, Yong-Yeng Lin   +3 more
openaire   +1 more source

Preservation of brevetoxins in Southwest Florida coastal sediments

Harmful Algae, 2022
Florida red tide is a natural phenomenon caused by the dinoflagellate, Karenia brevis. Karenia brevis blooms produce potent toxins (brevetoxins) that can cause neurotoxic and respiratory illness in humans and marine life. Red tides were recorded by Spanish explorers as early as the 17th century, however published red tide studies before 1940 are ...
James Javaruski, Puspa L. Adhikari, Joanne Muller, Michael L. Parsons   +3 more
openaire   +2 more sources

Cross resistance to brevetoxin-3 by kdr and super-kdr mutations in house flies.

Pesticide Biochemistry and Physiology
The dinoflagellate Karenia brevis is a causative agent of red tides in the Gulf of Mexico and generates a potent family of structurally related brevetoxins that act via the voltage-sensitive Na+ channel.
D. R. Swale, J. Bloomquist, Sarah E. McComic, Edwin R. Burgess   +3 more
semanticscholar   +1 more source

Spatiotemporal & cross-tissue brevetoxin analysis in juvenile blacktip sharks post-red tide exposure.

Integrative and Comparative Biology
Brevetoxins (PbTx), neurotoxins produced by the marine dinoflagellate Karenia brevis during harmful algal blooms (red tides), pose significant threats to marine fauna and coastal communities in the Gulf of Mexico. While acute toxicity is well-documented,
Sonia S. Ali, Rosamia C. Perez, Shivani Persaud Cowper, M. Sebastiani, S. Levell, Samuel A. Bedgood, J. Graham   +6 more
semanticscholar   +1 more source

Brevetoxin biosynthesis in Karenia brevis in relation to light, growth phase, and across the cell cycle.

Harmful Algae
Karenia brevis synthesizes picograms of brevetoxins per cell and regularly produces extensive blooms with cell concentrations exceeding 1 million cells L-1.
Charles L. Tilney, A. Hoeglund, Eric Muhlbach, L. Flewelling, M. Villa-C, D. Nieuwkerk, Sugandha Shankar, John H. Paul, K. Hubbard   +8 more
semanticscholar   +1 more source

Improved Synthesis of the ABCDE Fragment of Brevetoxin A

Organic Letters, 2006
A second-generation synthesis of the BCDE fragment of brevetoxin A is described. Novel reactions were developed that extend the utility of the asymmetric glycolate alkylation reaction and improve scale-up to provide gram quantities of the B and E subunits. Significant improvements to the convergent assembly of the tetracycle were also realized.
Michael T, Crimmins, Patrick J, McDougall, J Michael, Ellis   +2 more
openaire   +2 more sources

Brevetoxins: Toxicological Profile

2015
Brevetoxins (PbTxs) are polyether ladder-shaped neurotoxins produced by the dinoflagellate Karenia brevis. Blooms of K. brevis have been recorded since the mid-1800s, principally in the Gulf of Mexico but occasionally along the mid and south Atlantic coasts.
BROVEDANI, VALENTINA, PELIN, MARCO, D'ORLANDO, ELISABETTA, Poli, Mark   +3 more
openaire   +2 more sources

Immune effects of the neurotoxins ciguatoxins and brevetoxins

Toxicon, 2018
Ciguatoxins (CTXs) and brevetoxins (PbTxs) are phycotoxins that can accumulate along the marine food chain and thus cause seafood poisoning in humans, namely "ciguatera fish poisoning" (CFP) and "neurotoxic shellfish poisoning" (NSP), respectively. CFP is characterized by early gastrointestinal symptoms and typical sensory disorders (paraesthesia, pain,
Ophelie Pierre, Laurent Misery, Matthieu Talagas, Raphaele Le Garrec   +3 more
openaire   +2 more sources

Distribution of Brevetoxin to Lipoproteins in human plasma

Toxicon, 2007
To better understand the distribution of brevetoxins in lipoproteins, including their role in tissue delivery and toxin elimination in humans, we examined the interaction of brevetoxin congener PbTx-3 with human lipoproteins. In a scintillation proximity assay (SPA) and microtiter equilibrium dialysis, brevetoxin bound linearly to purified human high ...
Ricky T, Woofter, John S, Ramsdell
openaire   +2 more sources

Brevetoxins: unique polyether dinoflagellate toxins

The FASEB Journal, 1989
Brevetoxins are lipid‐soluble polyether marine toxins of unique structure and pharmacological function. Toxins are active in vivo in the nanomolar to picomolar concentration range and in vitro in isolated neuromuscular or giant axon preparations and in single‐cell or subcellular model systems.
openaire   +2 more sources