Results 41 to 50 of about 735 (162)
Convergent, Stereoselective Synthesis of the GHIJ Fragment of Brevetoxin A
, 2016 A stereoselective synthesis of the GHIJ fragment of brevetoxin A utilizing a convergent assembly strategy is described. Glycolate alkylation, ring-closing metathesis, and Hosomi−Sakurai reactions were central operations in the construction of the G ring ...
Michael T. Crimmins (1317639) +3 more
core +2 more sources
Brevenal inhibits pacific ciguatoxin-1B-induced neurosecretion from bovine chromaffin cells.
PLoS ONE, 2008 Ciguatoxins and brevetoxins are neurotoxic cyclic polyether compounds produced by dinoflagellates, which are responsible for ciguatera and neurotoxic shellfish poisoning (NSP) respectively. Recently, brevenal, a natural compound was found to specifically
César Mattei +9 more
doaj +1 more source
Marine Neurotoxins’ Effects on Environmental and Human Health: An OMICS Overview
Marine Drugs, 2021 Harmful algal blooms (HAB), and the consequent release of toxic metabolites, can be responsible for seafood poisoning outbreaks. Marine wildlife can accumulate these toxins throughout the food chain, which presents a threat to consumers’ health.
Sophie Guillotin, Nicolas Delcourt
doaj +1 more source
Spectroscopic ellipsometry methods for brevetoxin detection
Talanta, 2022 The spectroscopic ellipsometry (SE), and attenuated internal reflection spectroscopic ellipsometry (TIRE) are promising methods in label-free biosensing applications. An ellipsometer running under surface plasmon resonance (SPR) conditions has unique advantages over other SPR-based methods in terms of sensitivity and real-time/label-free measurement ...
Mustafa Oguzhan Caglayan +2 more
openaire +2 more sources
Marine Drugs, 2015 Regular occurrence of brevetoxin-producing toxic phytoplankton in commercial shellfishery areas poses a significant risk to shellfish consumer health. Brevetoxins and their causative toxic phytoplankton are more limited in their global distribution than
Andrew D. Turner +6 more
doaj +1 more source
Fluorescent Receptor Binding Assay for Detecting Ciguatoxins in Fish. [PDF]
PLoS ONE, 2016 Ciguatera fish poisoning is an illness suffered by > 50,000 people yearly after consumption of fish containing ciguatoxins (CTXs). One of the current methodologies to detect ciguatoxins in fish is a radiolabeled receptor binding assay (RBA(R)).
D Ransom Hardison +11 more
doaj +1 more source
Toxins, 2021 In this study, Karenia brevis 165 (K. brevis 165), a Chinese strain, was used to research brevetoxin (BTX) metabolites. The sample pretreatment method for the enrichment of BTX metabolites in an algal culture medium was improved here.
Huihui Shen +6 more
doaj +1 more source
Marine DrugsTo identify differentially abundant polyketide synthases (PKSs) and to characterize the biochemical consequences of brevetoxin biosynthesis, bottom-up, TMT-based quantitative proteomics and redox proteomics were conducted to compare two strains of the ...
Kathleen S. Rein +5 more
doaj +1 more source
Marine Drugs, 2021 In recent decades, more than 130 potentially toxic metabolites originating from dinoflagellate species belonging to the genus Karenia or metabolized by marine organisms have been described.
Vincent Hort +4 more
doaj +1 more source
Toxicon, 1992 The marine toxins known generically as brevetoxins, as well as their structural relative ciguatoxin, are known as polyether ladder toxins, and bind uniquely to site 5 of the voltage-sensitive sodium channel. Rat brain synaptosome binding data show similarities in binding affinity for brevetoxins having the same structural (ladder) backbone, but ...
R E, Gawley +3 more
openaire +2 more sources