Results 11 to 20 of about 1,646 (159)

Brevetoxin Metabolites: Emerging Toxins in French Shellfish Determined by LC-MS/MS and ELISA [PDF]

Mar Drugs
In France, as part of the monitoring program for the emergence of marine toxins in shellfish (EMERGTOX), brevetoxins (BTX-2, BTX-3) were first detected in shellfish from Corsica (Mediterranean Sea) in 2018.
Derrien, Amelie, Korian Lhaute, Simon Tanniou, Terrillon, Aouregan, Amélie Derrien, Lhaute, Korian, Tanniou, Simon, Zouher Amzil, Aouregan Terre Terrillon, Amzil, Zouher   +9 more
core   +3 more sources

Molecular Determinants of Brevetoxin Binding to Voltage-Gated Sodium Channels

Toxins, 2019
Brevetoxins are produced by dinoflagellates such as Karenia brevis in warm-water red tides and cause neurotoxic shellfish poisoning. They bind to voltage-gated sodium channels at neurotoxin receptor 5, making the channels more active by shifting the ...
Todd Scheuer, William A. Catterall, Daniel G. Baden, Keiichi Konoki   +3 more
core   +2 more sources

Comparative Quantitative Proteomic Analysis of High and Low Toxin-Producing Karenia brevis Strains Reveals Differences in Polyketide Synthase Abundance and Redox Status of the Proteome. [PDF]

Mar Drugs
To identify differentially abundant polyketide synthases (PKSs) and to characterize the biochemical consequences of brevetoxin biosynthesis, bottom-up, TMT-based quantitative proteomics and redox proteomics were conducted to compare two strains of the ...
Rein KS, Colon R, Romagosa CR, Ohnikian NR, Francis KT, Rein SR.   +5 more
europepmc   +2 more sources

Brevetoxin Dynamics and Bioavailability from Floc Following PAC-Modified Clay Treatment of Karenia brevis Blooms. [PDF]

Toxins (Basel)
Harmful algal blooms (HABs) caused by the dinoflagellate Karenia brevis present serious ecological and public health concerns due to the production of brevetoxins (BTX).
Ohnikian NR, Sibley CD, Freiberger RB, Buck KN, Myers A, Harlow S, Anderson DM, Pierce R, Toyoda JH.   +8 more
europepmc   +2 more sources

Brevetoxin versus Brevenal Modulation of Human Nav1 Channels. [PDF]

Mar Drugs, 2023
Brevetoxins (PbTx) and brevenal are marine ladder-frame polyethers. PbTx binds to and activates voltage-gated sodium (Nav) channels in native tissues, whereas brevenal antagonizes these actions.
Finol-Urdaneta RK, Zhorov BS, Baden DG, Adams DJ.   +3 more
europepmc   +2 more sources

Immune Modulating Brevetoxins: Monocyte Cytotoxicity, Apoptosis, and Activation of M1/M2 Response Elements Is Dependent on Reactive Groups. [PDF]

Mar Drugs, 2022
Brevetoxins are a suite of marine neurotoxins that activate voltage-gated sodium channels (VGSCs) in cell membranes, with toxicity occurring from persistent activation of the channel at high doses.
McCall JR, Sausman KT, Keeler DM, Brown AP, Turrise SL.   +4 more
europepmc   +2 more sources

Brevetoxin-Producing Spherical Cells Present in Karenia brevis Bloom: Evidence of Morphological Plasticity?

Journal of Marine Science and Engineering, 2019
Spherical cells were detected in low salinity waters during a bloom of Karenia brevis in Alabama coastal waters. These balls resembled K. brevis in size and organelle appearance, contained similar concentration of brevetoxin, and occurred during ongoing ...
Lucie Novoveská, Alison Robertson
core   +2 more sources

Comparative analysis of three brevetoxin-associated bottlenose dolphin (Tursiops truncatus) mortality events in the Florida Panhandle region (USA) [PDF]

PLoS ONE, 2012
In the Florida Panhandle region, bottlenose dolphins (Tursiops truncatus) have been highly susceptible to large-scale unusual mortality events (UMEs) that may have been the result of exposure to blooms of the dinoflagellate Karenia brevis and its ...
Schwacke, Lori, Gaydos, Joseph K, Bowen-Stevens, Sabrina R, Johnson , Christine K., Fire, Spencer E, Leighfield, Tod A., Gaydos Joseph K., Spencer E. Fire (142689), Fire , Spencer E., Joseph K Gaydos, Landsberg, Jan H., Flewelling, Leanne J, Leighfield Tod A., Michael J Twiner, Fire, Spencer E., Christine K. Johnson (142701), Landsberg Jan H., Schwacke Lori, Teresa K. Rowles (142717), Michael J. Twiner (142684), Spencer E Fire, Bowen-Stevens Sabrina R., Twiner , Michael J., Van Dolah Frances M., Teresa K Rowles, Mase-Guthrie Blair, Twiner, Michael J, Blair Mase-Guthrie (142707), Rowles Teresa K., Bowen-Stevens, Sabrina R., Leanne J. Flewelling (22010), Zhihong Wang, Joseph K. Gaydos (142699), Zhihong Wang (142713), Christine K Johnson, Gaydos, Joseph K., Tod A. Leighfield (22017), Johnson Christine K., Johnson, Christine K, Flewelling, Leanne J., Jan H Landsberg, Rowles, Teresa K, Van Dolah, Frances M., Sabrina R Bowen-Stevens, Flewelling Leanne J., Landsberg, Jan H, Frances M Van Dolah, Wang, Zhihong, Tod A Leighfield, Mase-Guthrie, Blair, Leanne J Flewelling, Frances M. Van Dolah (22016), Rowles, Teresa K., Jan H. Landsberg (22004), Lori Schwacke (29493), Sabrina R. Bowen-Stevens (142694), Blair Mase-Guthrie, Twiner Michael J., Lori Schwacke, Van Dolah, Frances M, Twiner, Michael J., Wang Zhihong, Fire Spencer E., Leighfield, Tod A   +63 more
core   +3 more sources

Predicting Karenia brevis Induced Respiratory Irritation at Individual Southwest Florida Beaches Using Cell Abundances Plus Wind Direction and Speed [PDF]

GeoHealth, Volume 10, Issue 4, April 2026.
Abstract Nearly annually, blooms of the dinoflagellate Karenia brevis form along the southwest Florida coast leading to a variety of negative impacts, including respiratory irritation (RI) in humans. To limit these impacts, NOAA's National Centers for Coastal Ocean Science (NCCOS) developed a RI model to provide beach‐goers with a category‐based ...
K. M. Collins, A. G. Hounshell, B. Kirkpatrick, A. Cook, K. A. Hubbard, M. C. Tomlinson, R. P. Stumpf   +6 more
wiley   +2 more sources

Emerging Insights into Brevetoxicosis in Sea Turtles. [PDF]

Animals (Basel)
This review summarizes the current understanding of how brevetoxins, produced by Karenia brevis during harmful algal blooms, impact sea turtle health.
Nederlof RA, van der Veen D, Perrault JR, Bast R, Barron HW, Bakker J.   +5 more
europepmc   +2 more sources