Brevetoxin Aptamer Selection and Biolayer Interferometry Biosensor Application. [PDF]
Toxins (Basel)Brevetoxins (PbTxs) are very potent marine neurotoxins that can cause an illness clinically described as neurologic shellfish poisoning (NSP). These toxins are cyclic polyether in chemistry and have increased their geographical distribution in the past 2
Hu B +8 more
europepmc +2 more sources
Brevetoxin PbTx2 Modulates Oxidative Stress and Inflammatory Response in an In Vitro Human Immune Cell Line. [PDF]
ToxicsBrevetoxins (PbTx) exert detrimental effects on marine organisms and humans, mainly through alterations in immune cell function. This study evaluated the immunotoxic potential of sublethal concentrations of PbTx-2 using the THP-1 human monocyte cell line
Aballay-González A +6 more
europepmc +2 more sources
"Algal-dromes": a novel conceptual approach to illness in humans exposed to harmful algal bloom toxins. [PDF]
Front ToxicolAlthough adverse health effects from harmful algal bloom (HAB) toxins have been described since antiquity, the true worldwide incidence and disease burden has yet to be defined.
Johnson B, Richlen M, Lai J, Twiner MJ.
europepmc +2 more sources
Synthesis of the A−F Fragment of the Pacific Ciguatoxin CTX3C by Iterative Ring‐Closing Metathesis and Tsuji–Trost Allylation [PDF]
Chemistry – A European Journal, Volume 29, Issue 72, December 22, 2023., 2023 The fully functionalized A−F ring system of the Pacific ciguatoxin CTX3C suitable for coupling to the I−M fragment of the natural product, has been synthesized from a simple glucal derivative. A six‐step sequence that features ring‐closing metathesis and stereoselective palladium‐mediated allylation has been deployed in an iterative manner to construct
Myron Triantafyllakis +4 more
wiley +2 more sources
Effects of Four Marine Toxins on Murine Hepatic Biotransformation Enzymes. [PDF]
Toxins (Basel)This study assesses the impact of sublethal levels of four marine toxins ciguatoxin (CTX-1), maitotoxin-2 (MTX-2), saxitoxin (STX) and brevetoxin-2 (BTX-2) on murine hepatic detoxification enzymes expressed in mouse liver.
Soto de Jesus J +5 more
europepmc +2 more sources
Design of a Duplex-to-Complex Structure-Switching Approach for the Homogeneous Determination of Marine Biotoxins in Water. [PDF]
Toxins (Basel)In this report, we describe a fluorescent assay for the detection of six marine toxins in water. The mechanism of detection is based on a duplex-to-complex structure-switching approach.
Al-Tabban A +5 more
europepmc +2 more sources
The Cardioprotective Potential of Marine Venom and Toxins. [PDF]
Toxins (Basel)Cardiovascular disease (CVD) continues to be the primary cause of morbidity and mortality worldwide, underscoring the urgent need for novel therapeutic alternatives.
Siagian VHM, Nuwarda RF.
europepmc +2 more sources
HABs Karenia brevis and Pseudo-nitzschia pre- and post-Hurricane Michael. [PDF]
J Water Health, 2023 Increased occurrences of harmful algal blooms (HAB) in the Gulf of Mexico, and even worldwide, yield concern for increases in brevetoxin exposure leading to respiratory illness or even death, highlighting the need for extensive scientific research and ...
Alarcon J +8 more
europepmc +2 more sources
Foods, 2021 The consumption of shellfish contaminated with brevetoxins, a family of ladder-frame polyether toxins formed during blooms of the marine dinoflagellate Karenia brevis, can cause neurotoxic poisoning, leading to gastroenteritis and neurotoxic effects.
Xiya Zhang +8 more
doaj +1 more source
Frontiers in Marine Science, 2021 Exposure of common bottlenose dolphins (Tursiops truncatus) to brevetoxins (PbTx) produced by blooms of the toxic phytoplankton Karenia brevis frequently results in severe health impacts, including illness and large-scale mortality events.
Spencer E. Fire +3 more
doaj +1 more source