Results 1 to 10 of about 55,078 (177)

Acid-Catalyzed Hydrolysis of Bridged Bi- and Tricyclic Compounds. XXIX. 7-Oxa-5-oxo-2-bicyclo[2.2.1]heptene: Kinetics and Mechanism. [PDF]

Acta Chemica Scandinavica, 1991
7-Oxa-5-oxo-bicyclo [2.2.1] heptene (7-oxanorborn-2-en-5-one) produces in concentrated (5-8.5 mol dm −3 ) aqueous perchloric acid mainly 1,2-dihydroxybenzene. The reaction is initiated by the pre-equilibrium protonation of the ether oxygen atom and the subsequent rupture of the C(1)-O(7) bond.
Martti Lajunen, Esa Mäki, Arne Holm, Niels Harrit, Lars I. Elding, I. Trabjerg   +5 more
semanticscholar   +3 more sources

Catalytic asymmetric tandem Heck/Sonogashira reaction enabling access to versatile chiral bridged ring scaffolds [PDF]

Nature Communications
Bridged-ring scaffolds are prevalent in numerous natural products and pharmaceuticals. However, achieving enantioselective construction of these architectures presents a significant challenge, due to the considerable structural strain of the products and
Jing Zhong, Mengxian Li, Changhui Wu, Hui Li, Hongyue Dong, Chunchen Che, Aijun Lin, Hequan Yao   +7 more
doaj   +3 more sources

Switchable organocatalytic enantioselective sulfenocyclization of cyclohexadienes enabling chemodivergent access to chiral bicyclo[m.n.1] ring systems [PDF]

Nature Communications
The precise control over regio- and stereoselectivity from the same substrate represents a significant challenge in organic chemistry. Herein, a switchable organocatalytic enantioselective carbosulfenylation/sulfenolactonization of cyclohexa-1,4-dienes ...
Bing-Qian Zhang, Lei Chen, Wen-Ying Xiao, Yidong Liu, Yin-Long Li, Jun Deng   +5 more
doaj   +3 more sources

Annulation of Hydroxyarenes and Derivatives with Bicyclo[1.1.0]butanes by Synergistic Combination of Metal Lewis Acid and Organic Acid. [PDF]

JACS Au
The development of new approaches to synthesize complex structures from readily available compounds is a topic of significant interest in synthetic chemistry.
Guo Q, Ni D, Deng L.
europepmc   +2 more sources

One-pot Diels–Alder cycloaddition/gold(I)-catalyzed 6-endo-dig cyclization for the synthesis of the complex bicyclo[3.3.1]alkenone framework

Beilstein Journal of Organic Chemistry, 2011
The rapid synthesis of bicyclo[m.n.1]alkanone cores possessing quaternary carbon centers adjacent to a bridged ketone represents a significant synthetic challenge.
Boubacar Sow, Gabriel Bellavance, Francis Barabé, Louis Barriault   +3 more
doaj   +2 more sources

Synthesis and Reactivity of Triphosphaallyl Cation Stabilized by N-Heterocyclic Carbenes. [PDF]

Chemistry
Reduction of the triphosphaallyl species 6[GaCl4] with GaI[Ga2Cl7] affords the imidazoliumyl‐substituted (L) bicyclo[2.1.1]‐triphosphane 10[Ga2Cl7], featuring an unprecedented Ga2Cl5‐bridged P3 scaffold.
Frötschel-Rittmeyer J, Hennersdorf F, Fidelius J, Sala C, Ziegler C, Holthausen M, Schwedtmann K, Wolf R, Weigand JJ.   +8 more
europepmc   +2 more sources

Bridged Bicyclic Building Block Upgrading: Photochemical Synthesis of bicyclo[3.1.1]heptan-1-Amines

, 2020
Compounds containing bridged bicyclic carbon skeletons are desirable building blocks for medicinal chemistry. However, as a result of their inefficient, linear syntheses, commercially available compounds of this sort are plagued by high costs and/or a ...
Alexander S. Harmata, Madison J. Sowden, C. Stephenson   +2 more
semanticscholar   +1 more source

Synthesis of polysubstituted bicyclo[2.1.1]hexanes enabling access to new chemical space

Chemical Science, 2023
Saturated bridged-bicyclic compounds are currently under intense investigation as building blocks for pharmaceutical drug design. However, the most common methods for their preparation only provide access to bridgehead-substituted structures.
Marius Reinhold, Justin Steinebach, C. Golz, Johannes C. L. Walker   +3 more
semanticscholar   +1 more source

Escaping from Flatland: Antimalarial Activity of sp3-Rich Bridged Pyrrolidine Derivatives.

ACS Medicinal Chemistry Letters, 2020
We utilized synthetic photochemistry to generate novel sp3-rich scaffolds and report the design, synthesis, and biological testing of a diverse series of amides based on the 1-(amino-methyl)-2-benzyl-2-aza-bicyclo[2.1.1]hexane scaffold.
B. Cox, James Duffy, Victor Zdorichenko, C. Bellanger, Jessica Hurcum, B. Laleu, K. Booker‐Milburn, Luke D. Elliott, Michael Robertson-Ralph, C. Swain, S. J. Bishop, I. Hallyburton, Mark B. Anderson   +12 more
semanticscholar   +1 more source

Catalytic Cyclocodimerization of Silicon-Containing 1,2-Dienes with 1,3,5-Cycloheptatriene in the Synthesis of Biologically Active Bicyclo[4.2.1]Nona-2,4-Dienes

Chemistry Proceedings
The [6+2] cycloaddition of (2-butyl-2,3-butadienyl)(trimethyl)silane and 2,3-butadienyl(trimethyl)silane to 1,3,5-cycloheptatriene was studied using titanium- and cobalt-containing multicomponent catalytic systems: R2TiCl2-R’nAlCl3-n (R = acac, PriO ...
Gulnara N. Kadikova
doaj   +1 more source