A combination of topical and systemic administration of brimonidine is neuroprotective in the murine optic nerve crush model. [PDF]
PLoS ONEGlaucoma is a multifactorial optic neuropathy that primarily affecting retinal ganglion cells (RGC). Brimonidine is an intraocular pressure-lowering drug with reported neuroprotective properties. This study aimed to compare the neuroprotective effects of
Ruta Maciulaitiene +3 more
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Brimonidine as a possible treatment for myopia
BMC OphthalmologyBackground Myopia is becoming a huge burden on the world’s public health systems. The purpose of this study was to explore the effect of brimonidine in the treatment of form-deprivation myopia (FDM) and the relationship between intraocular pressure (IOP)
Zixuan Peng +8 more
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Central Nervous System Depression After Topical Administration of Brimonidine Eye Drops to Induce Vomiting in a Cat [PDF]
Veterinary Medicine and ScienceBrimonidine stimulates the chemoreceptor trigger zone via alpha‐2 adrenergic receptors in the postrema of the medulla, which triggers vomiting in cats.
Dalhae Kim +4 more
doaj +3 more sources
The Efficacy and Safety Associated with Switching from Concomitant Brimonidine and Ripasudil, or Brimonidine or Ripasudil Monotherapy to a Fixed Combination of Brimonidine and Ripasudil in Glaucoma Patients. [PDF]
J Clin MedObjectives: The purpose of this study was to investigate switching from brimonidine and ripasudil, and brimonidine or ripasudil, to a fixed combination of brimonidine and ripasudil, and evaluate the associated efficacy and safety in glaucoma patients ...
Onoe H +8 more
europepmc +4 more sources
Nummular keratitis: A rare manifestation of brimonidine allergy
Oman Journal of Ophthalmology, 2023 A 32-year-old male, with juvenile open-angle glaucoma on chronic antiglaucoma therapy and recently introduced brimonidine eye drops to the treatment regimen, developed bilateral follicular conjunctivitis with subepithelial infiltrates (SEIs) initially ...
Maitha Al Asmi, Aisha Al Busaidi
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Brimonidine is Neuroprotective in Animal Paradigm of Retinal Ganglion Cell Damage
Frontiers in Pharmacology, 2021 To investigate the neuroprotective effect of brimonidine after retinal ischemia damage on mouse eye. Glaucoma is an optic neuropathy characterized by retinal ganglion cells (RGCs) death, irreversible peripheral and central visual field loss, and high ...
Federica Conti +11 more
doaj +2 more sources
PLoS ONE, 2022 Purpose To evaluate the concentrations of brimonidine and timolol in the vitreous and aqueous humors after instillation of a 0.1% brimonidine tartrate and 0.5% timolol fixed-combination ophthalmic solution.
Yusuke Orii +7 more
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Topical brimonidine induced acute uveal effusion in a patient with nanophthalmos: a case report
BMC Ophthalmology, 2023 Background We report a case of uveal effusion in a nanophthalmic eye after topical use of brimonidine. Case presentation A 42-year-old male patient with nanophthalmos experienced sudden blurred vision in the right eye after using topical brimonidine when
Yakun Li, Qi Zhou
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Scientific Reports, 2023 This multicenter (four institutions), randomized, investigator-masked, parallel-group clinical trial evaluated and compared the efficacy and safety of preservative-free and preserved brimonidine tartrate 0.15% in open-angle glaucoma and ocular ...
Ko Eun Kim +4 more
doaj +2 more sources
Ocular and Systemic Pharmacokinetics of Brimonidine and Timolol After Topical Administration in Rabbits: Comparison Between Fixed-Combination and Single Drugs [PDF]
Ophthalmology and Therapy, 2020 Introduction This study was aimed to compare ocular tissue distribution and systemic exposure of brimonidine and timolol after single topical administration to rabbits of fixed-combination ophthalmic solution of 0.1% brimonidine tartrate and 0.5% timolol
Gen Suzuki +5 more
doaj +2 more sources