Pharmacovigilance analysis of vision disorders relating to brimonidine treatment and mechanism study using network toxicology and molecular docking [PDF]
Scientific ReportsPrevious studies have reported that brimonidine, a widely used therapeutic agent, may be associated with vision-related adverse effects that can lead to serious clinical consequences. In this study, we conducted a comprehensive pharmacovigilance analysis
Lvjie Xu +6 more
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Intravitreal brimonidine inhibits form-deprivation myopia in guinea pigs [PDF]
Eye and Vision, 2021 Background The use of ocular hypotensive drugs has been reported to attenuate myopia progression. This study explores whether brimonidine can slow myopia progression in the guinea pig form-deprivation (FD) model.
Yifang Yang +8 more
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Effect of a fixed combination of ripasudil and brimonidine on aqueous humor dynamics in mice [PDF]
Scientific ReportsRipasudil–brimonidine fixed-dose combination (K-232) simultaneously targets three different intraocular pressure (IOP) lowering mechanisms, increasing trabecular meshwork outflow and uveoscleral outflow, and reducing aqueous humor production Vascularly ...
Reiko Yamagishi-Kimura +2 more
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Topical brimonidine induced acute uveal effusion in a patient with nanophthalmos: a case report [PDF]
BMC Ophthalmology, 2023 Background We report a case of uveal effusion in a nanophthalmic eye after topical use of brimonidine. Case presentation A 42-year-old male patient with nanophthalmos experienced sudden blurred vision in the right eye after using topical brimonidine when
Yakun Li, Qi Zhou
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Central Nervous System Depression After Topical Administration of Brimonidine Eye Drops to Induce Vomiting in a Cat [PDF]
Veterinary Medicine and ScienceBrimonidine stimulates the chemoreceptor trigger zone via alpha‐2 adrenergic receptors in the postrema of the medulla, which triggers vomiting in cats.
Dalhae Kim +4 more
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Comparison between latanoprost and brimonidine efficacy and safety in Indian eyes
Indian Journal of Ophthalmology, 2003 Purpose: To compare the short-term efficacy and safety of topical latanoprost and brimonidine in Indian eyes. Materials and Methods: Twenty-eight patients with ocular hypertension, primary open-angle, pseudoexfoliation or pigmentary glaucoma were ...
Thomas Ravi +5 more
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Effect of Solution pH on Distribution of Ophthalmically Administered Brimonidine in Posterior Ocular Tissues in Pigmented Rabbits [PDF]
Ophthalmology and Therapy, 2019 Introduction Brimonidine bioavailability in the aqueous humor depends on the solution pH following topical administration. The purpose of this study was to investigate the effect of solution pH on brimonidine distribution in the posterior ocular tissues ...
Keisuke Shinno +5 more
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Pupillometry changes following ocular administration of brimonidine in patients experiencing acute migraine attack. [PDF]
Medicine (Baltimore)Karakaya C, Kilic S, Yildirim I.
europepmc +2 more sources
Switching to Brimonidine/Ripasudil Fixed Combination from Brimonidine + Ripasudil
Clinical OphthalmologyKenji Inoue,1 Minako Shiokawa,1 Shiho Kunimatsu-Sanuki,2 Goji Tomita,1,3 Kyoko Ishida3 1Inouye Eye Hospital, Tokyo, Japan; 2Nishikasai Inouye Eye Hospital, Tokyo, Japan; 3Department of Ophthalmology, Toho University Ohashi Medical Center, Tokyo ...
Inoue K +4 more
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PLoS ONE, 2022 PurposeTo evaluate the concentrations of brimonidine and timolol in the vitreous and aqueous humors after instillation of a 0.1% brimonidine tartrate and 0.5% timolol fixed-combination ophthalmic solution.MethodsThis single-arm open-label interventional ...
Yusuke Orii +7 more
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