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Pharmacovigilance analysis of vision disorders relating to brimonidine treatment and mechanism study using network toxicology and molecular docking [PDF]

Scientific Reports
Previous studies have reported that brimonidine, a widely used therapeutic agent, may be associated with vision-related adverse effects that can lead to serious clinical consequences. In this study, we conducted a comprehensive pharmacovigilance analysis
Lvjie Xu, Shuyang Zhao, Sixuan Zhao, Zhe Wang, Jiansong Fang, Chuipu Cai, Jiawei Wang   +6 more
doaj   +2 more sources

Central Nervous System Depression After Topical Administration of Brimonidine Eye Drops to Induce Vomiting in a Cat [PDF]

Veterinary Medicine and Science
Brimonidine stimulates the chemoreceptor trigger zone via alpha‐2 adrenergic receptors in the postrema of the medulla, which triggers vomiting in cats.
Dalhae Kim, Jaehan Jun, Eunbin Park, Joohyun Jung, Won‐gyun Son   +4 more
doaj   +2 more sources

Brimonidine and timolol concentrations in the human vitreous and aqueous humors after topical instillation of a 0.1% brimonidine tartrate and 0.5% timolol fixed-combination ophthalmic solution: An interventional study

PLoS ONE, 2022
Purpose To evaluate the concentrations of brimonidine and timolol in the vitreous and aqueous humors after instillation of a 0.1% brimonidine tartrate and 0.5% timolol fixed-combination ophthalmic solution.
Yusuke Orii, Eriko Kunikane, Yutaka Yamada, Masakazu Morioka, Kentaro Iwasaki, Shogo Arimura, Akemi Mizuno, Masaru Inatani   +7 more
doaj   +2 more sources

Preliminary evaluation of the efficacy and safety of brimonidine for general anesthesia

BMC Anesthesiology, 2021
Background To determine the hypnotic and analgesic effects of brimonidine, and evaluate its efficacy and safety for general anesthesia. Potentiation of pentobarbital sleeping time following brimonidine administration was observed in mice, as was the ...
Chen Bin, Wang Xiaohui, Shi Mengrou, Li Xin, Zhang Ting, Gao Ping   +5 more
doaj   +1 more source

Efficacy and safety of various brimonidine formulations in the treatment of glaucoma and ocular hypertension

Офтальмохирургия, 2021
Purpose. To present data on the mechanism of action, efficacy, and side effects of various brimonidine dosage forms in the treatment of glaucoma and ocular hypertension.Material and methods. To perform the review, literature sources were searched through
A. V. Sidorova, A. S. Zhuravlev, A. V. Starostina, M. A. Eliseeva   +3 more
doaj   +1 more source

Effect of brimonidine tartrate on basophil activation in glaucoma patients

International Journal of Ophthalmology, 2020
AIM: To evaluate the mechanism of which brimonidine tartrate 0.15% causes clinical hypersensitivity. METHODS: A prospective case-control study comparing 8 glaucoma patients with clinical hypersensitivity to brimonidine to a control group consisting 13 ...
Eldar Rosenfeld, Dana Barequet, Gilad Rabina, Sheila Langier, Moshe Lazar, Gabi Shemesh, Shimon Kurtz, Shmuel Kivity   +7 more
doaj   +1 more source

Brimonidine is Neuroprotective in Animal Paradigm of Retinal Ganglion Cell Damage

Frontiers in Pharmacology, 2021
To investigate the neuroprotective effect of brimonidine after retinal ischemia damage on mouse eye. Glaucoma is an optic neuropathy characterized by retinal ganglion cells (RGCs) death, irreversible peripheral and central visual field loss, and high ...
Federica Conti, Giovanni Luca Romano, Chiara Maria Eandi, Mario Damiano Toro, Mario Damiano Toro, Robert Rejdak, Giulia Di Benedetto, Francesca Lazzara, Renato Bernardini, Filippo Drago, Giuseppina Cantarella, Claudio Bucolo   +11 more
doaj   +1 more source

Efficacy of three different formulations of brimonidine for control of intraocular pressure in primary open-angle glaucoma: A 6-week randomized trial

Oman Journal of Ophthalmology, 2018
BACKGROUND: To compare the intraocular pressure (IOP)-lowering efficacy and safety of brimonidine (0.2%), brimonidine purite (0.15%), and brimonidine purite (0.1%) in patients of primary open-angle glaucoma (POAG).
Anubha Bhatti, Gursatinder Singh
doaj   +1 more source

Intravitreal brimonidine inhibits form-deprivation myopia in guinea pigs

Eye and Vision, 2021
Background The use of ocular hypotensive drugs has been reported to attenuate myopia progression. This study explores whether brimonidine can slow myopia progression in the guinea pig form-deprivation (FD) model.
Yifang Yang, Junshu Wu, Defu Wu, Qi Wei, Tan Zhong, Jun Yang, Xiaowei Yang, Meizhen Zeng, Xingwu Zhong   +8 more
doaj   +1 more source

Evaluation of brimonidine-timolol fixed combination in patients of primary open-angle glaucoma

Indian Journal of Ophthalmology, 2013
The aim of present study was to compare the efficacy and safety of fixed combination of brimonidine and timolol with individual components used as monotherapy in patients of primary open angle glaucoma.
Sachin R Joshi, Pramod B Akat, Jaiprakash B Ramanand, Sunita J Ramanand, Vitthal B Karande, Suyog S Jain   +5 more
doaj   +1 more source