Preliminary evaluation of the efficacy and safety of brimonidine for general anesthesia
BMC Anesthesiology, 2021 Background To determine the hypnotic and analgesic effects of brimonidine, and evaluate its efficacy and safety for general anesthesia. Potentiation of pentobarbital sleeping time following brimonidine administration was observed in mice, as was the ...
Chen Bin +5 more
doaj +1 more source
PLoS ONE, 2022 Purpose To evaluate the concentrations of brimonidine and timolol in the vitreous and aqueous humors after instillation of a 0.1% brimonidine tartrate and 0.5% timolol fixed-combination ophthalmic solution.
Yusuke Orii +7 more
doaj +2 more sources
PSS11 A COST-EFFECTIVENESS ANALYSIS OF BRIMONIDINE/TIMOLOL
Value in Health, 2008 Eve J. Higginbotham, LI Stern, JG Walt
openalex +3 more sources
MOF-Based Polymeric Nanocomposite Films as Potential Materials for Drug Delivery Devices in Ocular Therapeutics [PDF]
, 2021 Novel MOF-based polymer nanocomposite films were successfully prepared using Zr-based UiO-67 as a metal-organic framework (MOF) and polyurethane (PU) as a polymeric matrix. Synchrotron X-ray powder diffraction (SXRPD) analysis confirms the improved stability of the UiO-67 embedded nanocrystals and scanning electron microscopy images confirm their ...
arxiv +1 more source
Intravitreal brimonidine inhibits form-deprivation myopia in guinea pigs
Eye and Vision, 2021 Background The use of ocular hypotensive drugs has been reported to attenuate myopia progression. This study explores whether brimonidine can slow myopia progression in the guinea pig form-deprivation (FD) model.
Yifang Yang +8 more
doaj +1 more source
Multidisciplinary Consideration of Potential Pathophysiologic Mechanisms of Paradoxical Erythema with Topical Brimonidine Therapy. [PDF]
, 2016 Rosacea is a chronic inflammatory disease with transient and non-transient redness as key characteristics. Brimonidine is a selective α2-adrenergic receptor (AR) agonist approved for persistent facial erythema of rosacea based on significant efficacy and
Detmar, Michael +6 more
core +2 more sources
Therapeutic approaches with intravitreal injections in geographic atrophy secondary to age-related macular degeneration: current drugs and potential molecules [PDF]
, 2019 The present review focuses on recent clinical trials that analyze the efficacy of intravitreal therapeutic agents for the treatment of dry age-related macular degeneration (AMD), such as neuroprotective drugs, and complement inhibitors, also called ...
Cerini, Alberto +5 more
core +1 more source
Development and Characterization of Hot-melt Extruded Biodegradable Poly(lactide-co-glycolide) Implants [PDF]
, 2023 The influence of three different extrusion methods as well as extrusion temperature and screw speed on drug release from PLGA-based implants were investigated. Comparing biodegradable implants prepared with the Haake MiniLab under extrusion parameters
Märker, Sebastian
core +1 more source
Rare diseases leading to childhood Glaucoma. epidemiology, pathophysiogenesis, and management [PDF]
, 2015 Noteworthy heterogeneity exists in the rare diseases associated with childhood glaucoma. Primary congenital glaucoma is mostly sporadic; however, 10% to 40% of cases are familial. CYP1B1 gene mutations seem to account for 87% of familial cases and 27% of
Abdolrahimzadeh, Solmaz +5 more
core +3 more sources
Where does selective laser trabeculoplasty stand now? A review [PDF]
, 2016 Background: Chronic treatment of glaucoma can present a challenge in patients who lack the means and/or the discipline to use daily glaucoma medication. We wondered if selective laser trabeculoplasty (SLT) could be a useful alternative.
De Belder, Maya +3 more
core +2 more sources