Results 61 to 70 of about 1,511 (168)

Effect of topical brinzolamide on visual function and waveform in patients of infantile nystagmus syndrome: A randomized control trial

Indian Journal of Ophthalmology
Purpose: To evaluate the effect of topical carbonic anhydrase inhibitor (brinzolamide) versus placebo on visual function and waveforms in infantile nystagmus syndrome (INS). Design: Prospective, placebo-controlled, double-blind, cross-over study. Methods:
Bhupendra Yadav, Rohit Saxena, Rebika Dhiman, Kanwal P. Kochhar, Ashlesh Patil, Pradeep Sharma, Ramanjit Sihota, Radhika Tandon   +7 more
doaj   +1 more source

Intravitreal Ranibizumab Had Limited Effect on Cystoid Macular Edema Due to Albumin-Bound Paclitaxel: A Case Report and Literature Review

Frontiers in Oncology, 2021
Angiographically silent cystoid macular edema (CME) is a rare complication from nab-paclitaxel. Here we report a 45-year-old woman with breast cancer who developed CME after several months of treatment with albumin-bound paclitaxel (nab-paclitaxel).
Suna Ye, Suna Ye, Qiqi Fang, Jinyu Yao, Jianqiang Xing, Shibo Tang, Shibo Tang, Jacey Hongjie Ma, Jacey Hongjie Ma   +8 more
doaj   +1 more source

The carbonic anhydrase enzymes as new targets for the management of neglected tropical diseases

Archiv der Pharmazie, Volume 358, Issue 1, January 2025.
The scientific literature dealing with the identification and development of selective inhibitors of the carbonic anhydrases expressed by the protozoans Trypanosoma cruzi (T. cruzi) and Leishmania spp. is reviewed and analyzed, with the aim to sustain the validation process of new classes of drugs useful for the management of neglected tropical ...
Gioele Renzi, Federico Ladu, Fabrizio Carta, Claudiu T. Supuran   +3 more
wiley   +1 more source

A comparative study on efficacy of fixed combination timolol/brinzolamide versus travoprost monotherapy in drug-naïve open-angle glaucoma patients

Therapeutic Advances in Ophthalmology, 2020
Background: Glaucoma is most common irreversible cause of blindness in India. First line management of open-angle glaucoma is either beta blockers or prostaglandin analogs monotherapy.
Alok Dixit, Atul Ashish, Reena Sharma
doaj   +1 more source

Sinus bradycardia following single-day use of timolol eye drops in a healthy young adult - A rare case report

Journal of Clinical Ophthalmology and Research, 2021
We report the rare case of timolol-induced sinus bradycardia in an otherwise healthy young individual following just 1 day use of timolol eye drops.
Sandip Sarkar, Pragathi Shankaralingappa, Amit Kumar Deb, Sangaraju Suneel, Subashini Kaliaperumal, Kaviyapriya Natarajan, Sasikumar Mahalingam   +6 more
doaj   +1 more source

Covalent Labeling-Mass Spectrometry for Characterizing Protein-Ligand Complexes [PDF]

, 2020
This dissertation focuses on applying covalent labeling (CL) and mass spectrometry (MS) for characterizing protein-ligand complexes. Understanding protein-ligand interactions has both fundamental and applied significance.
LIU, TIANYING
core   +3 more sources

Lasamide Containing Sulfonylpiperazines as Effective Agents for the Management of Glaucoma Associated Symptoms

ChemMedChem, Volume 19, Issue 24, December 16, 2024.
Amidation of Lasamide with piperazines led to potent and selective inhibitors of the human Carbonic Anhydrase (hCA, EC: 4.2.1.1) II isoform, whose role in glaucoma has been longtime validated. Insight into the interaction with the enzyme was gained through in silico studies.
Jaydeo T. Kilbile, Suryakant B. Sapkal, Gioele Renzi, Ilaria D'Agostino, Mohamed Boudjelal, Yasinalli Tamboli, Luigi Cutarella, Mattia Mori, Silvia Sgambellone, Serafina Villano, Silvia Marri, Laura Lucarini, Simone Carradori, Fabrizio Carta, Claudiu T. Supuran   +14 more
wiley   +1 more source

Brinzolamide loaded core-shell nanoparticles for enhanced coronial penetration in the treatment of glaucoma

Journal of Applied Biomaterials & Functional Materials, 2020
A neurodegenerative disorder, glaucoma is a leading cause of blindness in the world. The conventional treatment strategies do not allow the significant penetration of the drug in the cornea.
Jing Song, Ziping Zhang
doaj   +1 more source

Safety, tolerability, and efficacy of fixed combination therapy with dorzolamide hydrochloride 2% and timolol maleate 0.5% in glaucoma and ocular hypertension. [PDF]

, 2010
Glaucoma is a collection of diseases characterized by multifactorial progressive changes leading to visual field loss and optic neuropathy most frequently due to elevated intraocular pressure (IOP).
Bell, Nicholas P, Feldman, Robert M, Ramos, José L   +2 more
core   +3 more sources

New Sulfonate Ester‐Linked Fluorinated Hydrazone Derivatives as Multitarget Carbonic Anhydrase and Cholinesterase Inhibitors: Design, Synthesis, Biological Evaluation, Molecular Docking and ADME Analysis

Chemistry &Biodiversity, Volume 21, Issue 12, December 2024.
Abstract In this study, some new hydrazone derivatives (2a–g) was designed, synthesized for first time, and evaluated as multitarget inhibitors of AChE, BChE, hCA I and hCA II. The chemical structures of new hybrids were confirmed by elemental analysis and some spectroscopic techniques.
Berna Akış, Reşit Çakmak, Murat Şentürk   +2 more
wiley   +1 more source