Results 131 to 140 of about 2,664 (258)

Enabling Cross‐Coupling Reactivity of α‐Pentafluorosulfanyl Compounds with a Thermally Stable Organozinc α‐SF5 Reagent

open access: yesChemistry – A European Journal, EarlyView.
This work describes the first example of a thermally stable α‐SF5 organometallic reagent, which allows for extensive downstream functionalization by allylation and acylation reactions under copper catalysis, as well as palladium‐catalyzed Negishi‐type cross‐coupling conditions up to 96% yield. In silico analysis shines initial light on the requirements
Lujie Xu, David Rombach
wiley   +1 more source

β‐Ketonitrile‐Modified Prodan Derivatives as Large‐Stokes‐Shift Solvatochromic Fluorophores With Enhanced Brightness and Ratiometric Thermometric Response

open access: yesChemistry – A European Journal, EarlyView.
We report a systematic study of β‐ketonitrile–modified Prodan‐type solvatochromic fluorophores. The β‐ketonitrile substitution induces marked bathochromic shifts in absorption and emission and significantly enhances fluorescence quantum yields in nonpolar solvents.
Hiroaki Asakawa   +3 more
wiley   +1 more source

Halogenated Tryptophans Improve Integrin αVβ6 Affinity of Cyclic RGD Peptides and Provide Handles for Late‐Stage Derivatization

open access: yesChemistry – A European Journal, EarlyView.
Lighting up αVβ6: Halotryptophan engineering converts an RGD scaffold into a modular αVβ6 ligand platform, enabling picomolar affinity and late‐stage functionalization. The resulting probes combine high selectivity with fluorescence for FACS and tumor imaging.
Beate Nachtigall   +4 more
wiley   +1 more source

Infrared Irradiation‐Assisted Pd‐Catalyzed C(sp3)─H Arylation and Tandem Cyclization of Ortho‐Tolualdehydes

open access: yesChemistry – A European Journal, EarlyView.
A rapid and efficient protocol for the synthesis of 2‐benzylbenzaldehydes and anthracenes is reported, based on the infrared (IR) irradiation‐assisted Pd‐catalyzed C(sp3)─H arylation and the tandem C(sp3)─H arylation/electrophilic aromatic cyclization of ortho‐tolualdehydes with aryl iodides via a transient directing group (TGD) strategy.
Matteo Renato Martina   +6 more
wiley   +1 more source

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